<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20713

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPVQIGSDGQLVPLGGPVVSGPQPPPPGTPATPGIRLSLLIEFLLQRTYHEITLLAELLPRKTDMERKIEIVQFASRTRQLFVRLLSLVKWASNAGKVEKCAMISSFLDQQTILFVDTADRLASLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKNEKQTTLSQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSLQVNFIHELVQARLCADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQEERYVPAKYLTLTVWNQQVLGRKTGTASVHKVTIKIDESDGSKPLQISHEPPLPACDSKLIERAMKIDHLSVEKLLIDSVHARSHQKLQELKAILKASNPSDNSFIETALPTLIIPILEPCGRSECLHIFVDLHSGMFQPMLYGLDQSMLDDIEKTINDDMKRMISWLQQLKFWLGEQRSRQSVKHLPTVCTDVLHLSNSASHPVGNLSKHKLFIKLTRLPQYYIVVEMLEVPSSPTALQYKYSFLSVSQLEGDDGPMCAQLLQHFKPNLEHLVQDTTAGRGARPGSKRKTFGDQGDPEPKKPKRSGEMCAFNKELAHLVAMCDTNMPFIGLRTELSNMEIPNQGVQVEGDGSSHAIRLLKIPPCKGVGEETRRALSRSLLDCTFRLQGRNNRTWVAELMLANCPLNSTHSKEQASTRHVYLTYENPLSEPVGGRKVVEMFLNDWNAISQLYQCVLNFARALPEMPSYLSLFSEVRLYNYRKLVLCYGTTKGSSVTIQWNSSSQRFHLALGTVGPNSGCSNCHNIILHQLQEMFNKSPNVMQLLQVLSDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVTEDDNPPSPVGVDVMDTLMNQLQAQQQQQQHLPAKDYSPSPPSFSVCVCVRASVWNIHASGSPSGALRAPSPFGPTPSPSSLGIAMSQTNFASPHGALDPSSPYAMVSPSHRGQWPGSPQVSGPSPGARIHGMSPGNPSLHSPIPDPHSPRAATSSQVMPTSMPPPRKLPQRPWAASIPTILTHNALHVLLLPSPTPCLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQEANLSIVNSNEPGVIMFKTDVLKCRVALNPKNYQTLQLKVTPENTGPWSQEELQVLEKFFETRVAGPPFKYNTLNAFTKLLGAPTNILRDCVRIMKLELFPDQAAQLKWNVQFCLTIPPSAPPIAPPGTIAVVLKSKMLFFLQLTQRIPVPQEPVNIIVPIVYDMATGLTQQADIPRQHSSSGAAALMVSNILKRFNELHPARQVELQVRRPLMPVQLGPEQVGLEMLCLCEQLDLLIRAQMQQFQEQLGHGCSPEESDTFQAQGSEILDQMLQCLEHLPKPMPQLEDYLDMTGLSAMFPRVEVFLIQGSPVEMLERPPMDDYFFHIAKLNQLLVLSQQLEEDMRHLGSHKYIAHQLSVIYQVISSFGGIQVFSEIKKDIEANFKQMKQSLASDEGSRHEPQLAAHYTNWKAKSSGAVNQSEDESGNENRQKNVRRRRRAHDTSENVTRKSARAASSGVGRAGGGGRGNTRRHVEAVTLFEVVTMGRSAMQVVIDDWIEAYATDRDSSLLDLISFFIQCSGCKGVVTAEMCQSREDGDLMSKMVEELDEDGVVEYPLVQSGPYGRWFHSEFCDFVSVLVAQYQQHGVIFDGYLMNTLISLLTELSNSYIRAFRHTCTLAAVKLLSSLAAVALSLSVGTENSQKLYKVQKTKTTRQKGTAQLERIQKKITELQEKRTEIESMMDVIFKGVFLKRYRDALPEIRSLCVEELGLWMKLDSSAFLNDPYLKYMGWTMYDKIPDVRLKCVLGLQCLYGNPLLLAKLDLFTSRFKDRMISMTLDKDNEVAVQSMKLLLLISKTSDDVLSADDYQQLLRFVYSSQRPLAAAAGELLYSRLLNSDTQDDLNEEEEAHELPTSARLKALLRFHQESELHTHVVYLVDSLWDCGGALLKDWATLTSILLQDPSSHGPGLTLAEQAVLVEILVASVRQASEGPVVVGRSGAKKVMSARDKKVQIDDSTKFTQHLLPVLPKLLSKFSSYPDVVASLMKIPQFFLPECPEAENTQAVSSLVAEMGNVLDVHSDPAVLEAAARTYLSLCGDEATWSSTARDARDALVQTWVERLTVLLGDSLKENCFAADGEKTRDILAALKKLRAFHNCHDLSGWSLFELLSPLLSVESSLGGAPPEVLLEVLQCLSYFMLWSLNTSGETLTSREKAVAQRLQLRLFCERSHHCLSHCDHIVRHQAFLGVCDVLTAHSFQRHVWDPTSFGPLAYTPSPRLQRALSSFVCLHVFVGPDCDSQSRVSENSGVEKLEDLHRRRNLLAAFCKLVVHGVLEMSMAAEVFMYYVKYYNDFGDIIKETMYRARRTDKIESTRTLVLCLQQLFVRLKREQESGGGRAQPGVQTFTSIKELARRFALTFGDLVKFRECVVVIHRSGVEFVFQEFSQTPETPTPLYLSYLTILSEFSSKLLKPDKKTVFCYLQKLTAEHVTDLREERWQPLIYYRASLLAAAEGEDAASFVSSGRKPQPPNRSPFSKQKLDGSKSPCPFSPADSKGSKGHRSKFSPSRQERTTTDVDPFSVPLDPPAGKLNTEGSVLSTNHEVDDDTVEIEL
Length2745
PositionTail
OrganismScophthalmus maximus (Turbot) (Psetta maxima)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Carangaria> Pleuronectiformes> Pleuronectoidei> Scophthalmidae> Scophthalmus.
Aromaticity0.07
Grand average of hydropathy-0.211
Instability index50.69
Isoelectric point6.89
Molecular weight306710.08
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20713
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.48|      47|    1011|     935|     984|       1
---------------------------------------------------------------------------
  935-  984 (74.83/65.92)	KIVEG...FYPAPGLKTFLNMFVDSNQDaRRRSVTEDDNPPspVGVDVMDTLM
 1939- 1988 (71.66/50.48)	KCVLGlqcLYGNPLLLAKLDLFTSRFKD.RMISMTLDKDNE..VAVQSMKLLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     257.22|      98|    1011|     687|     786|       2
---------------------------------------------------------------------------
  688-  742 (75.67/53.51)	..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LS...................................................................................................................RSLLDCTFRLQGRNNRTW..VAELMLANCPLNSTHS.....KEQASTRHVYLTYENPLSE
  743-  785 (50.55/32.78)	P.VGGRKVVEMFLNDWNAISQLYQCVLNFARALPEMPSYLSLFS.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 2072- 2126 (46.86/28.04)	............................................evrlynyrklvlcygttkgssvtiqwnsssqrfhlalgtvgpnsgcsnchniilhqlqemfnkspnvmqllqvlsdtqaplnainklptvpmlgltqrtntayqcfsilpqspthirlafrnmycidiycrsrgvvairdgayslfdntkivegfypapglktflnmfvdsnqdarrrsvteddnppspvgvdvmdtlmnqlqaqqqqqqhlpakdyspsppsfsvcvcvrasvwnihasgspsgalrapspfgptpspsslgiamsqtnfasphgaldpsspyamvspshrgqwpgspqvsgpspgarihgmspgnpslhspipdphspraatssqvmptsmppprklpqrpwaasiptilthnalhvlllpsptpclvpglagsylcsplerflgsvimrrhlqriiqqeanlsivnsnepgvimfktdvlkcrvalnpknyqtlqlkvtpentgpwsqeelqvlekffetrvagppfkyntlnaftkllgaptnilrdcvrimklelfpdqaaqlkwnvqfcltippsappiappgtiavvlkskmlfflqltqripvpqepvniivpivydmatgltqqadiprqhsssgaaalmvsnilkrfnelhparqvelqvrrplmpvqlgpeqvglemlclceqldlliraqmqqfqeqlghgcspeesdtfqaqgseildqmlqclehlpkpmpqledyldmtglsamfprvevfliqgspvemlerppmddyffhiaklnqllvlsqqleedmrhlgshkyiahqlsviyqvissfggiqvfseikkdieanfkqmkqslasdegsrhepqlaahytnwkakssgavnqsedesgnenrqknvrrrrrahdtsenvtrksaraassgvgraggggrgntrrhveavtlfevvtmgrsamqvviddwieayatdrdsslldlisffiqcsgckgvvtaemcqsredgdlmskmveeldedgvveyplvqsgpygrwfhsefcdfvsvlvaqyqqhgvifdgylmntlislltelsnsyirafrhtctlaavkllsslaavalslsvgtensqklykvqktkttrqkgtaqleriqkkitelqekrteiesmmdvifkgvflkryrdalpeirslcveelglwmkldssaflndpylkymgwtmydkipdvrlkcvlglqclygnplllakldlftsrfkdrmismtldkdnevavqsmkllllisktsddvlsaddyqqllrfvyssqrplaaaagellysrllnsdtqddlneeeeahelptsarlkallrfhqeselhthvvyLV...................................................................................................................DSLWDCG....GALLKDWatLTSILLQD.P..SSHGpgltlAEQAVLVEILVASVRQASE
 2128- 2171 (41.00/23.18)	PvVVGRSGAKKVMSARDKKVQIDDSTKFTQHLLPVLPKLLSKFS.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 2287- 2330 (43.14/24.95)	....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................sypdvvaslmkipqfflpecpeaentqavsslvaemgnvldvhsdpavleaaartylslcgdeatwsstardardalvqtwverltvllgdslkencfaadgektrdilaalkklRAFHNC.HDLSG.....W.sLFELL...SPLLSVES.....SLGGAPPEVLLEVLQCLS.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     220.88|      68|     482|     817|     892|       3
---------------------------------------------------------------------------
  817-  892 (107.91/88.78)	RFHLALGTVGPNSGCSNCHNIILHQlQEMFnkspnVMQLLQVLSDTQAPLNAInkLPTV.PM.LGLTQRTNTAYQCFS
 1308- 1377 (112.97/71.21)	QFCLTIPPSAPPIAPPGTIAVVLKS.KMLF.....FLQLTQRIPVPQEPVNII..VPIVyDMaTGLTQQADIPRQHSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     111.95|      22|      28|    1027|    1048|       4
---------------------------------------------------------------------------
 1027- 1048 (44.28/25.10)	SPSGALRAPSPFGPTPSPSSLG
 1058- 1078 (38.29/20.40)	SPHGALDPSSPYAMV.SPSHRG
 1102- 1121 (29.38/13.42)	NPSLHSPIPDPHSPRAATSS..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.02|      28|     727|     409|     438|       5
---------------------------------------------------------------------------
  409-  438 (47.26/30.18)	ASNPSdnSFIETALPTLIIPILEPC......GRSEC
 1141- 1174 (46.76/23.99)	ASIPT..ILTHNALHVLLLPSPTPClvpglaGSYLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     210.77|      66|    1011|     221|     293|       6
---------------------------------------------------------------------------
  151-  218 (109.56/73.13)	GSYPRLP.TCIRDKIIPPDPITKNEKQTTLS.QLNQIlrHRLVTTDLPPQLANL.TVANGRVKFRVEGEFE
  225-  293 (101.21/76.18)	GDDPDIPwRLLKLEILVEDKETGDGRALVHSlQVNFI..HELVQARLCADEKPLqDMYNCLHSFCLSLQLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.09|      27|      28|    1707|    1733|       7
---------------------------------------------------------------------------
 1707- 1733 (50.04/33.53)	DLISFFIQCSGCKGVVTAEMCQSREDG
 1734- 1760 (48.05/31.86)	DLMSKMVEELDEDGVVEYPLVQSGPYG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.68|      26|      28|    1434|    1461|       8
---------------------------------------------------------------------------
 1434- 1460 (41.19/20.74)	IRAQMQQFQEQLGHGcSPEESDTFQAQ
 1464- 1489 (44.50/19.19)	ILDQMLQCLEHLPKP.MPQLEDYLDMT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     311.11|     100|     151|     295|     401|       9
---------------------------------------------------------------------------
  295-  401 (156.69/122.17)	LHSQTL..MLIRERWGDLVQEERYVPAKYLTLTVWNQQV...LGRKTGTASV.HKVTIKIDESDGSKplQISHePPLPACDSKLIERAMKID..HLSVEKLLIDSvharSHQKLQ
  445-  552 (154.42/100.74)	LHSGMFqpMLYGLDQSMLDDIEKTINDDMKRMISWLQQLkfwLGEQRSRQSVkHLPTVCTDVLHLSN..SASH.PVGNLSKHKLFIKLTRLPqyYIVVEMLEVPS....SPTALQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.69|      32|      35|    1601|    1633|      10
---------------------------------------------------------------------------
 1601- 1633 (52.98/32.60)	AHYT..NWKAKSSGAVNQSEDESGNENRqKNVRRR
 1636- 1669 (51.71/27.61)	AHDTseNVTRKSARAASSGVGRAGGGGR.GNTRRH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.53|      18|      36|    1216|    1233|      11
---------------------------------------------------------------------------
 1216- 1233 (33.52/19.81)	DVL....KCRVALNPKNYQTLQ
 1250- 1271 (28.01/15.29)	QVLekffETRVAGPPFKYNTLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.41|      29|    2432|      62|      97|      12
---------------------------------------------------------------------------
   62-   97 (40.90/51.98)	RKTDmerKIEIVQ.FASRTRQLFVRLlslvKWASNAG
 2499- 2528 (46.50/35.41)	RRTD...KIESTRtLVLCLQQLFVRL....KREQESG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20713 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ARRRSVTEDDNPPSPVGVDVMDTLMNQLQAQQQQQQHLPAKDY
2) SFVSSGRKPQPPNRSPFSKQKLDGSKSPCPFSPADSKGSKGHRSKFSPSRQERTTTDVDPFSVPLDPPAGKLNTEGSVLSTNHEVDDDTVEIEL
3) SGSPSGALRAPSPFGPTPSPSSLGIAMSQTNFASPHGALDPSSPYAMVSPSHRGQWPGSPQVSGPSPGARIHGMSPGNPSLHSPIPDPHSPRAATSSQVMPTSMPPPRKLPQRPWA
4) SSGAVNQSEDESGNENRQKNVRRRRRAHDTSENVTRKSARAASSGVGRAGGGGRG
5) VQDTTAGRGARPGSKRKTFGDQGDPEPKKPKRSGE
960
2652
1025
1610
586
1002
2745
1140
1664
620










Molecular Recognition Features






MoRF SequenceStartStop




NANANA