Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MTEMFSTLYGQNEAQAPPGASSLGFGPGKPPPPLQQNQASMPGQMPPQLGDEGPALRKPGAMNEPFYLLRELPVGNELTGNTNLITHYNLEHAYNKFCGKKVKEKLSNFLPELPGMIDCPGTQDGSSLRSLIDKPPVCGNSFSPLTGALLTGFRLHTGPLPEQYRLMHIQPPKKKSKHKHKHHRPQDPLPQETPSDSDPKKKKKKRDDDPDRKKKKKDKKKKKNRHSPDHPGLAGSQPNSNSLR |
Length | 244 |
Position | Head |
Organism | Scophthalmus maximus (Turbot) (Psetta maxima) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Carangaria> Pleuronectiformes> Pleuronectoidei> Scophthalmidae> Scophthalmus. |
Aromaticity | 0.05 |
Grand average of hydropathy | -1.127 |
Instability index | 52.98 |
Isoelectric point | 9.74 |
Molecular weight | 27048.62 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP20710 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 69.38| 14| 17| 198| 212| 1 --------------------------------------------------------------------------- 178- 190 (21.76/ 7.32) ..HKHKHHRPQDPLP 198- 212 (22.15/12.26) DpKKKKKKRDDDPDR 218- 230 (25.47/ 9.92) D.KKKKKNR.HSPDH --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 140.76| 43| 75| 47| 92| 3 --------------------------------------------------------------------------- 47- 92 (72.18/52.11) PQLGDeGPALR....KPGAMNEPFYLLRE.LPVGNEL.TGntNLITHYNLEH 120- 168 (68.58/39.67) PGTQD.GSSLRslidKPPVCGNSFSPLTGaLLTGFRLhTG..PLPEQYRLMH --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DPKKKKKKRDDDPDRKKKKKDKKKKKNRHSPDH 2) KKSKHKHKHH 3) YRLMHIQ | 198 174 164 | 230 183 170 |
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