<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20709

Description Putative mediator of RNA polymerase II transcription subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPSKISSNFSSIIAEKLRYNTFPDTGKRKPQVNQKDNFWLVTARSQSSINNWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYSVPVMRSAWMIKMTCAYHAAITETKVKKRHVIDPCIEWTQIITKYLWEQLQKVAEFYRQFPSQGCSSPLPATPADVETAMKQWEYNEKLAMFMFQDGMLDRHEFLTWVLECFEKVRPGEDELLRLLLPLLLQYSGEFVQSAYLSRRLAYFCTRRLNLLLSDGSLGPSTGGHPAHGILAQQGNALPPTPTSQPAGGNQPQTPFTDFYICPQHRPLVFGLSCMLQSIVLCCPSALVWHYSLTDSRNKTGSPLDLLPIATSNLPMPGGNTAFTQQVRTKLREIEEQIKERGQAVEFRWSFDKCQETTAGFTIGRVLHTLEVLDNHSFEKSDFNNSLDSLYNRIFGSGQSKDGHEMSPDDDAVVTLLCEWAVCCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEVVDEKGSVSSGSLSAATLPVFQDVLLQFLDTQAPTLTEPGNESERVEFSNLVLLFCELIRHDVFSHNIYMCTLISRGDLASDSHLPRPRSPSDEPSDDSERKEQEAGSSVKMEDAGLSESMEIDHNSSANFDEMFSPPMHCESKGSPSPEKQAPEQDSKAGCKDKGMDPAFPQLYEQPRHIQYATHFPIPQEESASHECNQRLVVLYGVGKLRDEARHTIKKITKDILKVLNRKSTAETGGEEGQKRKRSKPEAFPTAEDIFSKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHIQFIFDLMEYSLNISGLIDFAIQLLNELSLVEAELLLKSSSLVGSYTTSLCLCIVAVLRRYHSCLILNPEQTAQVFDGLRIVVKSGVNPADCSSAERCILAYLYDLYTSCSHLKNKFGEIFSEFCSKVKNSIYCNIDPSDSNMLWDPVFMMEAIANPSAHNFNHSMVGKILNDSPANRYSFVCNVLMDVCVDHRDPERVNDIGILCAELTAYCRSLSAEWLGILKALCCSSNNGNCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLVRCVAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQRNPVPQDGVKSVGIRSSCDRHLLAASQNSIVVGAVFAVLKAVFMLGDAELRGSVLLQPAGLDDISEGRNVSIETASLDVYAKYVLKTICQQEWVGERCLKSLSEDSSALQDPVLVNIQAQRLLQLICYPHRQLDSDDGDNPQRQRIKRILQNMDQWTMRQSSLELQLMIKQSTNNELYSLLENIAKATIEVFQKSAEMNSSNPSGNGAAVQGGSASNNSSTTSKMKPILSSSERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVQQIVTNWREDQYQDDCKAKQMMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSESLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFEKEGLQVSTKQKISPWDVFEGLKHSAPLSWGWFGTVRVDRKVTKFEEQQRFLLYHTHLKPKPRSYYLEPLPLPPEEEEPLTPVSQEPEKKMMEAVKPEKNVPAVPTDSNKKKSNKKKKTAAPKTEDYGNRTQGGVSYGTNMAPELMQNHPYGRLQYSQQAMSMYTQNQPLPPGGPGLEPPYRPARNPQMNKMPARASYPGMMPSMQGSMPGMMGMDKQYQMGYKPQNSMQQSQILRHQLQVRLNQSMIGQQMRQITPNQPYTPMQASQNISQGYTTYGSHMGMQQHPPQGGGIVPSSYGNQNFQGAHPGANPAVVDPLRQMQQRPSGYVHQQAPGYAHSMQNAQRFAHQPLQQNPIMHGLGHMGGQGVHLGLRPNQMLAEQQQQQQQQQQQAAQQQQQYLRQQALRQQQQQQQQQQQQQVPAVQPPGQAQNQGLGMQPLPPQQFPRQGMQQTQQQQQTAALVRQLQQQLSNTQPGQGTNSYY
Length2128
PositionKinase
OrganismScophthalmus maximus (Turbot) (Psetta maxima)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Carangaria> Pleuronectiformes> Pleuronectoidei> Scophthalmidae> Scophthalmus.
Aromaticity0.07
Grand average of hydropathy-0.499
Instability index55.55
Isoelectric point6.86
Molecular weight238288.12
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20709
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     193.71|      24|      26|    2018|    2041|       1
---------------------------------------------------------------------------
 1792- 1812 (31.49/10.21)	MQ....NHP......YGRLQYSQQAMSMY..TQ
 1875- 1895 (27.62/ 8.04)	MQ......QSQI...L.RHQLQVRLNQSM..IG
 1929- 1951 (27.55/ 8.00)	MQ....QHPPQGggiVPSSYGNQ...NFQ...G
 2018- 2039 (32.61/10.84)	......LRPNQM...LAEQQQQQQQQQQQ..AA
 2040- 2068 (28.70/ 8.65)	QQqqqyLR.QQA...LRQQQQQQQQQQQQqvPA
 2082- 2105 (45.73/18.18)	MQ....PLPPQQ...FPRQGMQQTQQQQQ..TA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.05|      12|      15|     855|     866|       2
---------------------------------------------------------------------------
  855-  866 (23.40/14.90)	IQFIFDLM.EYSL
  872-  884 (14.65/ 6.42)	IDFAIQLLnELSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.66|      14|      15|    1638|    1652|       3
---------------------------------------------------------------------------
 1638- 1652 (20.41/15.37)	TKgNKIAGFEK.EGLQ
 1655- 1669 (22.26/11.39)	TK.QKISPWDVfEGLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.85|      16|      16|     644|     659|       4
---------------------------------------------------------------------------
  644-  659 (27.33/14.47)	EPSDDSERKEQEAGSS
  663-  678 (27.53/14.63)	EDAGLSESMEIDHNSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     451.55|     143|     367|     321|     495|       5
---------------------------------------------------------------------------
  327-  495 (226.91/210.76)	AQQGNALPPTPTSQPAGGNQP..QTP................FTDFYICPQHRPLV..FGLScMLQSIVLCCPSALVWHYSLTDSRNKTGSPL.....DLLPIATSNLPMPGGNtaftqqvrtklreieeqikERGQAvefRWSFDKCQETTAGFTIGRVLHtLEVLDNHSFEKSDFNNSLDSLYNriFGSGQS
  679-  846 (224.64/142.78)	ANFDEMFSPPMHCESKGSPSPekQAPeqdskagckdkgmdpaFPQLYEQPRHIQYAthFPIP.QEESASHECNQRLVVLYGVGKLRDEARHTIkkitkDILKVLNRKSTAETGG...................EEGQK...RKRSKPEAFPTAEDIFSKFQH.LSHFDQHQVTSQVSRNVLEQITS..FALGMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.45|      21|      57|    1077|    1099|       6
---------------------------------------------------------------------------
 1077- 1099 (31.78/21.57)	ILKAlCCSSNNGNCGfNDLLCNV
 1137- 1157 (37.67/17.31)	LLNA.ACSEQDSEPG.ARLTCRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.75|      21|     107|    1705|    1725|       8
---------------------------------------------------------------------------
 1705- 1725 (37.30/21.39)	KPKPRSYYLEPLPLPPEEEEP
 1730- 1748 (30.33/15.95)	SQEPEKKMME..AVKPEKNVP
 1754- 1772 (22.12/ 9.55)	SNKKKSNKKKKTAAPKTED..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.71|      12|      15|    1004|    1015|       9
---------------------------------------------------------------------------
 1004- 1015 (22.62/14.72)	MMEAIANPSAHN
 1020- 1031 (21.10/13.15)	MVGKILNDSPAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.24|      21|      24|    1530|    1552|      11
---------------------------------------------------------------------------
 1530- 1552 (30.70/29.95)	QQTTewAVL.LLDIISSGTV..DMQS
 1555- 1578 (26.54/16.56)	ELFT..TVLdMLSVLINGTLaaDMSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.54|      13|      58|    1775|    1791|      14
---------------------------------------------------------------------------
 1775- 1787 (25.38/21.14)	NRTQGGVSYGTNM
 1915- 1927 (26.16/10.30)	NISQGYTTYGSHM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.55|      23|     342|     243|     265|      16
---------------------------------------------------------------------------
  243-  265 (44.70/25.02)	FQDGML.................DRHEFLTWVLECFEKVR
  571-  610 (28.86/13.73)	FQDVLLqfldtqaptltepgnesERVEFSNLVLLFCELIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.87|      11|      21|    1815|    1825|      23
---------------------------------------------------------------------------
 1815- 1825 (23.47/13.10)	PLPPGGPGLEP
 1839- 1849 (22.39/12.08)	PARASYPGMMP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20709 with Med12 domain of Kingdom Metazoa
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