<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20706

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMELAYVCEWDRRQRTTHCPSIPLVCSWSCRNLVAFTTDLKNHDDDKDVSHMIHIIDTEHPWDVYSINSGHTEVISCLEWDQSGSRLLSADGDGQIKCWSMSDHLVNSWESALCSSLDGDPIVALTWLHNGVKLALHVEMSGSTNFGEKFSRVKFSPSLTLFGGKPMEGWLAVTVSGLVTVSLLKPGGALLTASESLCRLRGRVALADIAFTGGGNIVVAATDGSSSSPVQFYKVVVSVVSEKCRIDTELLPSLFLRCTTDPLRREKYPAVTHLKFLTRENSEQVLLCASNQSGSIVECWSLRKEGLPVNNIFQHRSPVVGEKQPTILKWRILTTTNDLERVSSVALPKLPISISNTDLKVASDTKFCPGLGLALAFHDGSIQILHRLSLHTMGVYYGSSSSSQRPGDESAIKRQRTGGPALHFKALQFSWTSLALAGVDNQGKLHMLRVSPSMGQVLEMNTTLRHLLFLLEYCMVTGYDWWDVLLHVQPTMVHNLVEKLHEEYMRQNQALQQVLATRIVAVKASLCKLSTATAARACDFHAKLLLMAISSTLKSLLRPHVLNTPDKSPGDRLTEICAKNTDTDIDKVMINLKTEEFVLDGPPLQSLQQLIQWVGDFVLYLLANLPNQGSMVRPGFGFMRDGASLGMLREMLVMIRIWGLLKPGCLPTFTATSDNQDSMQLLFRLLTKLWLCSRDDGPPQDPDETLIDECCLLPSQLLVPSMDWLPVNDGVIVKLQGKHPLRLQFGKASSLGGGGATAPLDVFTR
Length764
PositionTail
OrganismScophthalmus maximus (Turbot) (Psetta maxima)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Carangaria> Pleuronectiformes> Pleuronectoidei> Scophthalmidae> Scophthalmus.
Aromaticity0.07
Grand average of hydropathy-0.016
Instability index42.12
Isoelectric point6.64
Molecular weight84395.52
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20706
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.99|      26|      69|       7|      33|       1
---------------------------------------------------------------------------
    7-   32 (57.37/29.51)	C.EWDRR.QRTTH........CPSIP..LVCSWS...CRNL
   76-  116 (28.62/ 8.49)	ClEWDQSgSRLLSadgdgqikCWSMSdhLVNSWEsalCSSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.68|      43|      95|     568|     611|       4
---------------------------------------------------------------------------
  568-  611 (69.96/49.32)	PGdRLTEICAKNTDTDIDKVMINLKTEEFVL...DGPPLQSLQQLIQ
  662-  707 (74.71/48.09)	PG.CLPTFTATSDNQDSMQLLFRLLTKLWLCsrdDGPPQDPDETLID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      68.66|      16|      74|     258|     273|       5
---------------------------------------------------------------------------
  258-  273 (28.48/18.13)	TTDPLRREKYPAVTHL
  317-  329 (16.60/ 7.65)	...PVVGEKQPTILKW
  334-  349 (23.58/13.81)	TTNDLERVSSVALPKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.56|      31|     347|     368|     401|       6
---------------------------------------------------------------------------
  368-  401 (46.77/35.71)	PGLGLaLAFHDGSIQILHrlSLHTMGVYYGSSSS
  719-  749 (56.80/32.87)	PSMDW.LPVNDGVIVKLQ..GKHPLRLQFGKASS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20706 with Med16 domain of Kingdom Metazoa
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