<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20691

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSSCFVPNGASLEDCHSNLFCLADLTGIKWRRFVWQGPTSSPILFPVTEEDPILCSFSRCLAADVLSVWRRHHTPGRRELWLFWWGDDPSFAELIHNELSSEEDGEWESGLSYECRTLLFKAIHNLLERCLMNRGFVRIGKWFVKPYQKEEKTINKSEHLSCAFTFFVHGDSNVCTSVEIAQHQPLQWLGEEHLSLAQQSSGPLQVILSPYGLNGTLTGQAFKMSDHPTQKLIEEWRQFYPISPNPKEVPEDKMEDTDWEDDSLAAVEVLVAGVRMVYPSCLVLLPLSDLPAVVPQGSANTSGSLCGAQQGHAAHRDPAMSSVTLTPPTSPEEAQTDYQPAQRWLKLSSASDGYSSNNSLHGGKIPRRLASQMVGSVWQEYNINRTGHKRKFTTLTNGTCEEESDKTGLWDFVESTQRPHCNCSRHKNQKQRSSSTSGHPPSLGQPVQPAPKHKLGEKLEKGEKQQKRPQTPFHHRNSVCEEQSLEPQTQRLCLRSQEEGSYPSLHHVDTVPSKAPTLHTHGPPADHVGSPPPPPLSPHPCDHGEGDMTPGGIKSSSTPIHQPFYPPSVEPCLLPQKGSSEEPQLETMPMPLPFPPSYNESLEPTVFVGSAINPNEDSTHNPWKYFNLPRKKASNFLTPLLPVDKIRDDSGGGGGAESVVSVTELMSGSMQPLKVSQELVKAYAQRRNSHLAPSTGDEEHSEEPDPYAFEEGDEEFTFTEKKDKAGAEREGNNKHKADEGNGTADDGQGPSGNKPSASTSLIHENDLAVSYSDLDKIFNSDEDELAPGSKRAGAGAEDKFGCKDTKAATLDPLSCISPADLHKMFPTPPSLEQQGYSPMNSGSKDSLEAGAGLTLLDGSQLNIHFKMEVEEGFCSPKPSEIKDFSFVYKPEPYHSFIGCSMYAPLKTLPSQCLLPIKLPEDCVYTRSWTLGKMELIPPVSNVNVLTKDGNVPSVEPDYSQTYTPQTHTPFMSSSAPPSNSGTTGILPSPATPRFSVPTPRTPRTPRTPRGPSSVQGSLKYDNSDLYSPASTPSTCRPLSSVEPATVPSIPEAHSLYVTLILSESVMNLYKDCNFDSCCVCVCNMNIRGSDVGVYLKDNGEAQYPCTCGFSAVTNRRFGQSAGLFLEDELDVVGRGSDSSRDTERCFEELRASTTHKAGSLKEKPPDELILLLQDQCTNPFAPMAGVEYPKPSSAPSSFVRVGERDCYNDCYMALEHGRQFMDNMSGGKVDETLVKSTCLHQWPKCKSADMSKLFSQDVLRVLLSLQPVLQDTIQKKRSVRSWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLVGYEYDFVVLSPFGLPYWEKLLLDPFGSQRDVGYVVICPDNGALLRGAKTFFKDLSAMYEACQLGQHRPICKSHPEGVMKVGTTEGRSMTEQPLSDWFLKMASRDGNNEAFNKLKLFAQVCRYDLAPYLSEQSLDSSLLSQRCPTVASSSSSSSSSSQTSSSSSTSSGPQSTNTTSTSSAQPAQVNSTPPSSSSGPQTIGGMASAKPSSYTPFGTAGLQGSISQNGPQSNPQGAGGPAENGPSANQPQGSTEPPESTMERDKVGKPTDGESHAVSYPPAIVVYIVDPFSYEDADREVHSSTYTLGLLRCYMEMLQFLPAHIRNAVSVQIVPCQYLLQPVRSGERRLYGQHLKSLAFSVFTQCRRPLPNSTNFKALTGFGPGLAIDMALKNPERPECLRLYTPPFILAPVKDKQTELGETFGEASQKYNILFVGYCLSHDQRWLLASCTDQHGELLETCIISVDVPNRARRKKGSARRLGLQKLWEWCLGLVQVTSLPWRVVIGRLGRMGHGELRDWSILLSRRNLQSLSKRLKETCRLCGISAADTPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLSTPQDTSCTHILVFPTSAMVQVNTNTSEPIDINFNPINPDGSDGMGIFDLFDNDMVDPDLINILPNSPTTSPVHSPGSHYHQGGDGSKGQSADRMESHEEALNILQQPMALGYFVSTAKAGPLPDWFWSACPQAQNQCPLFLKASLHLHVSSVQSDELLHSKHSHPLDSNHTSDVLRFVLEQYNALSWLTCDPATQDRRSCLPVHFVVLTQMYNFIMNML
Length2126
PositionMiddle
OrganismScophthalmus maximus (Turbot) (Psetta maxima)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Carangaria> Pleuronectiformes> Pleuronectoidei> Scophthalmidae> Scophthalmus.
Aromaticity0.08
Grand average of hydropathy-0.481
Instability index58.90
Isoelectric point5.67
Molecular weight233473.79
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20691
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     192.16|      34|      36|    1503|    1538|       1
---------------------------------------------------------------------------
  973- 1003 (28.56/ 7.68)	..........SSA.PP.SNSG..TTGilpSPATPRfsvPT..PRTPR
 1465- 1492 (29.91/ 8.47)	..........SSS.SSSSSSSQTSSS...SSTSSG...PQ..STNTT
 1493- 1530 (54.41/23.26)	STSSAQpaqvNST.PPSSSSGPQTIG...GMASAK...PS..SYTPF
 1531- 1565 (49.27/23.34)	GTAGLQ.gsiSQN.GPQSN..PQGAG...GPAENG...PS..ANQPQ
 1566- 1595 (30.01/ 9.00)	GST..........ePPESTMERDKVG...KPTDGE...SHavSYPP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     134.90|      31|      36|     548|     583|       2
---------------------------------------------------------------------------
  513-  546 (40.08/14.74)	........SKAPT.LHTHGPPADHvgspppPPLS......PHPCDHGEG
  548-  583 (51.22/32.90)	MtpggiKSSSTPI.HQPFYPPSVE......PCLL......PQKGSSEEP
  585-  622 (43.61/18.14)	L.....ETMPMPLpFPPSYNESLE......PTVFvgsainPNEDSTHNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.24|      26|      36|      30|      64|       3
---------------------------------------------------------------------------
   21-   57 (33.10/34.60)	CLA.DltgikWRRFvwQGPTSSPI.LFpVTEEDPilcSF
   60-   91 (44.14/21.64)	CLAaD.vlsvWRRH..HTPGRRELwLF.WWGDDP...SF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.96|      14|      27|    1085|    1098|       4
---------------------------------------------------------------------------
 1085- 1098 (25.28/18.29)	NIR.GSDVGVYLKDN
 1114- 1128 (20.68/13.32)	NRRfGQSAGLFLEDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.16|      26|      31|    1173|    1203|       5
---------------------------------------------------------------------------
 1176- 1203 (38.26/33.77)	CTNPfAPMAgVEYPKPSSAPSSFVRVGE
 1206- 1231 (47.89/19.97)	CYND.CYMA.LEHGRQFMDNMSGGKVDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.77|      14|      14|     830|     843|       9
---------------------------------------------------------------------------
  830-  843 (26.40/14.25)	SLEQQGYSPMNSGS
  846-  859 (20.36/ 9.00)	SLEAGAGLTLLDGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.82|      30|      40|    1005|    1035|      11
---------------------------------------------------------------------------
 1005- 1035 (50.86/30.98)	PRTPRGPSSVQgSLKYDNS............DLYSPASTPSTC
 1037- 1078 (47.95/24.51)	PLSSVEPATVP.SIPEAHSlyvtlilsesvmNLYKDCNFDSCC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.40|      13|      31|    1637|    1650|      13
---------------------------------------------------------------------------
 1637- 1650 (19.64/17.01)	HIRN.AVSVqIVPCQ
 1667- 1680 (19.76/11.12)	HLKSlAFSV.FTQCR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.87|      20|      39|     379|     398|      16
---------------------------------------------------------------------------
  379-  398 (35.58/20.74)	QEYNINRTGHK..RKFTTLTNG
  417-  438 (33.29/18.92)	QRPHCNCSRHKnqKQRSSSTSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.03|      27|      39|     286|     312|      17
---------------------------------------------------------------------------
  286-  312 (47.60/29.48)	PLSDLPAVVPQGSANTSGSLCGAQQGH
  328-  354 (48.43/30.16)	PTSPEEAQTDYQPAQRWLKLSSASDGY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.27|      15|      30|    1309|    1329|      21
---------------------------------------------------------------------------
 1313- 1329 (25.43/26.44)	IPTFlvGYEYD..FVVLSP
 1340- 1356 (24.84/ 7.47)	LDPF..GSQRDvgYVVICP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.90|      41|      44|     738|     778|      25
---------------------------------------------------------------------------
  738-  778 (71.16/37.77)	DEGN...GTADDGQGPSGNKPSASTSLIHENDLA.VSYSDLDKIF
  781-  825 (61.74/31.80)	DEDElapGSKRAGAGAEDKFGCKDTKAATLDPLScISPADLHKMF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20691 with Med13 domain of Kingdom Metazoa
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