<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20680

Description mediator of RNA polymerase II transcription subunit 23 isoform X3
SequenceMVQMETQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKTLTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEFIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTSCLASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSAQRSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVVHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVPIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRNRESLKRKLVHAIIGSLKDNRPQGWCLSDTYLKCAMNAREDNPWVPDDSYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGQDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAVPPQAINSGSPAPQSNQVPVSLPVTQ
Length1339
PositionTail
OrganismTursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Delphinidae> Tursiops.
Aromaticity0.10
Grand average of hydropathy-0.002
Instability index45.74
Isoelectric point7.19
Molecular weight152952.12
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20680
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.05|      10|      27|     138|     147|       1
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  138-  147 (15.61/ 9.78)	RDLLKVILEK
  167-  176 (16.44/10.69)	REVIAYILER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     809.69|     307|     660|      32|     532|       2
---------------------------------------------------------------------------
   32-  128 (28.57/503.43)	TPEDEKTKLISCL.GAFRQFW..GGLSQESH........EQCIQW........IVKFIHGQHSPKrisfLYDCL..AMAVETgllpprmvceslinsDTLEW......ERTQLWALTFKlVRKI.......................................................................................................................................................................................................................................................................................................................................................................................................
  209-  485 (302.03/262.38)	............................................................................................................................iggvdykgvrdllkvilektltipntvssavvqqllaareviayilernacllpayfavteirklypegklphwllgnlvSDF.VDTFRPTARINSIcGRCslLPVVNNsgaicNSWKLDPATL.RFPLkgLLPYDKHK....QRCPVLeDQLVdLvvyaMERSETEEKFDD....GGTSQLL...W..QHLSSQliffvlfqfASFPhmvlslhQKLAGRGLIKGRDHLMW............VLLQFIS.GSIQKNALADFLPVMK....LFDLLYPEKEFIPVPDINKPQSTHAFAMtciwiHLnRKAQNDNSKLQIPIPHSLKlHHEFLQQSLRNKSLQ..MNdykiALLCNAYSTNSECFTLPMGALVETIYGngimRIPLPGTSC
  694- 1061 (479.09/ 0.00)	TPHNWASHTLSCFpGPLQAFFkqNNVPQESRfnlkknveEEYRKWksmtnendIITHFSAQRSPP....LFLCLlwKMLLET...............DHINQigyrvlERIGARALVVH.VRTF................................................................................ADFlVYEFSTSAGGQQL.NKC..IEILND.....MVWKYNIVTLdRLIL..CLAMRSHEgneaQVCYFI.IQLL.L....LKPNDFRNRVSDfvkeNSPEHWLqndWhtKHMNYH.........KKYP.......EKLYFEGLAEQVDPPVPiqspylpiyfgnVCLRFLPvFDIVIHRFLELLPVSKsletLLDHLGGLYKFHDRPVTYLYNTLHYYEM.....HL.RNRESLKRKLVHAIIGSLK.DNRPQGWCLSDTYLKcaMN....AREDNPWVPDDSYYCKLIGRLVDTMAG....KSPGPFPNC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.05|      45|     660|     486|     532|       4
---------------------------------------------------------------------------
  486-  532 (71.08/49.75)	LASGSITP......LPMNLLDSLTVHAKMSLIHsiATRVIKLAHA...KSSV...ALAP
 1143- 1199 (65.97/40.21)	ISSPSLTSetewvgYPFRLFDFTACHQSYSEMS..CSYTLALAHAvwhHSSIgqlSLIP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20680 with Med23 domain of Kingdom Metazoa
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