<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20677

Description mediator of RNA polymerase II transcription subunit 23 isoform X5
SequenceMVQMETQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKTLTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQTLNIAQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEFIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTSCLASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSAQRSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVVHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVPIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRNRESLKRKLVHAIIGSLKDNRPQGWCLSDTYLKCAMNAREDNPWVPDDSYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGQDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRYWCGIL
Length1280
PositionTail
OrganismTursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Delphinidae> Tursiops.
Aromaticity0.10
Grand average of hydropathy-0.006
Instability index43.87
Isoelectric point7.17
Molecular weight146529.60
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20677
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     393.01|      83|     216|     174|     256|       1
---------------------------------------------------------------------------
  174-  256 (140.83/77.73)	LERNACLLPAY.FAVTEIRK.LYPEGKLPHWLLGNLVSDFVDTFRP.TARINSICGRC.SLLPVVNNSGA.....ICNSWKLDPATLRFPL.K
  257-  303 (42.52/18.58)	.................................GLLPYD.KDLFEPqTALLRYVLEQ.....PY..SRDM.....VCNMLGLNKQTLNIAQhK
  309-  388 (103.95/55.54)	LEDQLVDLVVYaMERSETEE.KFDDGGTSQLLWQHLSSQLI..FFV.LFQFASFPHMVlSLHQKLAGRGL.....IKGRDHLMWVLLQF....
  393-  472 (105.70/56.59)	IQKNA..LADF.LPVMKLFDlLYPEKEFIP......VPD.INKPQS.THAFAMTCIWI.HLNRKAQNDNSklqipIPHSLKLHHEFLQQSL.R
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     311.59|      97|     262|     531|     633|       3
---------------------------------------------------------------------------
  531-  633 (157.20/125.67)	PLPMNLLDSLTVHAKMslIHSIATRVIKLAHAKSSValapALVETYSRLLVYMEIESLG...IKGFISQLLPTVFKSHAWGI..LHTLLEMFSYRMHHIQP.HYRVQLL
  796-  898 (154.39/107.94)	PLFLCLLWKMLLETDH..INQIGYRVLERIGARALV....VHVRTFADFLVYEFSTSAGgqqLNKCIEILNDMVWKYNIVTLdrLILCLAMRSHEGNEAQVcYFIIQLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.18|      19|     222|    1034|    1052|       4
---------------------------------------------------------------------------
 1034- 1052 (35.49/22.03)	KLVHAIIGSLKDNRPQGWC
 1259- 1277 (37.69/23.86)	HLVGPFLQRFQQERTRYWC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.12|      10|      16|    1055|    1065|       7
---------------------------------------------------------------------------
 1055- 1065 (15.18/14.38)	DTYLkCAMNAR
 1074- 1083 (19.94/13.08)	DSYY.CKLIGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     150.03|      45|     716|      32|      76|       9
---------------------------------------------------------------------------
   32-   76 (86.47/50.55)	TPEDEKTKLISCL.GAFRQFW..GGLSQES........HEQCIQW........IVKFIHGQHSP
  732-  795 (63.56/35.26)	TPHNWASHTLSCFpGPLQAFFkqNNVPQESrfnlkknvEEEYRKWksmtnendIITHFSAQRSP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20677 with Med23 domain of Kingdom Metazoa
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