<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20676

Description mediator of RNA polymerase II transcription subunit 23 isoform X4
SequenceMVQMETQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKTLTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQTLNIAQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEFIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHDLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSAQRSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVVHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVPIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRNRESLKRKLVHAIIGSLKDNRPQGWCLSDTYLKCAMNAREDNPWVPDDSYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGQDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAVPPQAINSGSPAPQSNQVPVSLPVTQ
Length1295
PositionTail
OrganismTursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Delphinidae> Tursiops.
Aromaticity0.10
Grand average of hydropathy-0.021
Instability index45.82
Isoelectric point6.99
Molecular weight148454.82
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20676
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     561.80|     221|     260|     275|     534|       1
---------------------------------------------------------------------------
  275-  432 (169.59/159.77)	..............................................................................................................YVLE..QPYSRDMVCNMLglnkQTL.NIAQHKQR....CpvLEDQLVDLVVyAMERSETEEKFDD..GGTSQLLWQHlSSQLIFFVLFQFASFPHMVlslhQKLAGRGLIKG...RDhLMWVLLQFISGSIQKNALADFL.PVMKLF..DLLYPEKEFipvpdiN.KPQSTHAF
  433-  691 (317.03/261.09)	AMTC...IWIHLNrkAQNdNSKLQIPIPHSLKLHHDLIHSIATRVIKLAHAKSSValapALVETYSRLLVYMEIESLG...IKGFISQLLPTVFKshawgilhtllemfsYRMHhiQPHYRVQLLSHL....HTLaAVAQTNQNqlhlC..VESTALRLIT.ALGSSEVQPQFTRflSDPKTVLSAE.SEELNRALILTLARATHVT....DFFTGSDSIQGtwcKD.ILQTIMSFTPHNWASHTLSCFPgPLQAFFkqNNVPQESRF......NlKKNVEEEY
  696-  783 (75.17/35.82)	SMTNendIITHFS..AQR.SPPLFLCLLWKMLLETDHINQIGYRVLERIGARALV....VHVRTFADFLVYEFSTSAGgqqLNKCIEILNDMVWK.............................................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.33|      26|      89|     992|    1019|       2
---------------------------------------------------------------------------
  992- 1019 (47.06/34.18)	DSYYCKLIGRLVDTMAgkSPGPFPNCDW
 1085- 1110 (47.27/27.95)	EPYWIVLHDRIVSVIS..SPSLTSETEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     223.20|      68|     659|     191|     263|       5
---------------------------------------------------------------------------
  191-  263 (112.54/82.57)	RKLYPEgKLPHWLLGNLVSDFVDTFRPTARI..NSICGRcsLLPVVNNsgAICNSWKLDP.....ATLRFPLKGLLPY.DK
  852-  927 (110.67/65.02)	HKKYPE.KLYFEGLAEQVDPPVPIQSPYLPIyfGNVCLR..FLPVFDI..VIHRFLELLPvskslETLLDHLGGLYKFhDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.30|      19|     707|      85|     105|       7
---------------------------------------------------------------------------
   85-  105 (31.47/23.01)	CLAMAVETGllPPRMVCESLI
  795-  813 (36.83/21.12)	CLAMRSHEG..NEAQVCYFII
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20676 with Med23 domain of Kingdom Metazoa
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