<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20668

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMKKMKSRSTKASKCGLSNYSVLLFNKRIRFVMLLELEGPVSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEELKEEEELGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDLPVPQSVAGTGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAVIGESGGTQSAVSHLGSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPANNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPSRPPTISQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDPPGQKLGLAGIDSSLEVASSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETENLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSDKWWHSYHLPSIDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQMQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPEGKNAMSLFSSTKTDVRQDSAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPTVGTEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTQLTEFKVEVEDGLGSPKPEEIKDFSYVHKVPTLQPFVGSSMFAPLKMLPSQCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQTTFLPQMEGARKSQEPPISLLLLLQNQHTQPFASLSFLDYISCNNRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLAEELVSEWFNQPWGSEESDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQTPPAAAQGQATPGNAGPLASNPGSAAPSAGSAFNPTSNGSSVNPAASSSASGSSVPPASTSASAPIINQISTTSSSGFSGSVGAQNPSAGASSAERTQGNIGCGGDTEPGQSSSQPSQDGQESVTERERIGIPTEPDSADSQAYPPAVVIYMVDPFTYTAEEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIALPNRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKRLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2091
PositionMiddle
OrganismTursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Delphinidae> Tursiops.
Aromaticity0.07
Grand average of hydropathy-0.386
Instability index60.07
Isoelectric point5.76
Molecular weight228964.71
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20668
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     260.91|      64|      68|     398|     465|       1
---------------------------------------------------------------------------
  420-  485 (102.25/52.58)	QMNLNPMDSPHSPISPLPPTLS.PQPRGQETENLDPPSVP....VNPALYG....ngLELQQ.LSTLDDRTVL....VGQ
  486-  563 (74.02/43.51)	RLPLMAEVSETALYCGIRPS.N.PESSDKWWHSYHLPSIDdaefRPPELQGercdakMEVNSeSTALQRLLAQpnkrFKI
  564-  596 (41.35/14.92)	WQDKQPQMQPLHFLDPLP..LS.QQPGDSLGEVNDP............................................
 1378- 1414 (43.30/16.10)	RLKLYAQVCRHH.LAPYLATLQlD......SSLLIPPKYQ....TPPA................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.78|      41|     364|     343|     385|       2
---------------------------------------------------------------------------
  343-  385 (72.16/49.53)	PA..SSKHKTTERQEKGDKLQKRPLIPFHhrPSVAEELCMEQDPP
  707-  749 (71.62/42.59)	PAlrSSKMPTVGTEDRPLGKDGRAAVPYP..PTVADLQRMFPTPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     355.68|     104|     364|    1452|    1675|       3
---------------------------------------------------------------------------
  200-  249 (52.68/27.37)	......SNCGMPLtP.PTSPEQAV..IGESGGTQSA..VSHLGSQDGGMITMHSPKRSGKI.....................................................
  905-  990 (136.02/32.41)	NSAAPASNSGAGVlPsPATPRFSVP.........................TPRTPRT.PRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPlnsVEP..ATMQPIPEAHSLY
 1453- 1561 (166.98/150.49)	NPAASSSASGSSV.P.PASTSASAPiINQISTTSSSgfSGSVGAQNPSAGASSAERTQGNIGCGGDTEPGQSSSQPSQDGQESVTERERIGIP...TEPdsADSQAYPPAVVIY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     362.50|      87|     467|     810|     896|       4
---------------------------------------------------------------------------
  810-  896 (156.65/77.36)	KDFSYV..HKVP.....TLQPFVGSSMFAPLKMLP.SQ....CLLPLK..IPDACLFR...PSWAIPPKIEQLPMPPAATFIRDGYNNV.PSVG.SLAD...PDYLNTP
 1183- 1263 (96.80/45.12)	.................TVHSWPHSNVL.DISMLS.SQdvvrMLLSLQpfLQDAIQKKrtgRTWENIQHV.QGPLTWQQFHKMAGRG....TYG.SEES...PEPLPIP
 1271- 1367 (109.05/51.72)	KDFLTIspFSLPfwerlLLDPYGGHRDVAYIVVCPeNE....ALLE.....GAKTFFR...DLSAVYEMCRLGQHKPICKVLRDGIMRVgKTVAqKLAEelvSEWFNQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.93|      26|      28|    1949|    1976|       5
---------------------------------------------------------------------------
 1949- 1976 (37.05/29.83)	GsHFQhSRSQGERL...LSREAPEELKQQPL
 1979- 2007 (44.88/25.97)	G.YFV.STAKAENLpqwFWSSCPQAQNQCPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.08|      18|      28|    1747|    1773|       6
---------------------------------------------------------------------------
 1747- 1765 (30.33/35.49)	RSkVSAR..KIGLQKLWEWCI
 1776- 1795 (27.75/ 9.90)	RV.VIGRlgRLGHGELKDWSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.07|      20|      24|    1852|    1871|       7
---------------------------------------------------------------------------
 1852- 1871 (32.55/18.32)	VFGRSTALNMQSSQLNTPQD
 1877- 1896 (31.53/17.49)	ILVFPTSSTIQVAPANYPNE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.04|      23|      26|    1621|    1646|       8
---------------------------------------------------------------------------
 1624- 1646 (44.77/35.47)	YIQYLKSM..AFSVYCQCR...RPLPTQ
 1648- 1675 (30.27/13.18)	HIKSLTGFgpAASIEMTLKnpeRPSPIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.86|      19|      24|    1578|    1597|       9
---------------------------------------------------------------------------
 1578- 1597 (31.05/26.04)	NFWLLSLMRCyTEMLDNLPE
 1601- 1619 (34.81/23.13)	NSFILQIVPC.QYMLQTMKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.28|      11|      24|    1911|    1922|      10
---------------------------------------------------------------------------
 1911- 1922 (17.73/11.94)	PFPDDmDNDIGI
 1938- 1948 (21.55/ 9.59)	PSPGS.PSGIGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.49|      21|      28|    2037|    2057|      11
---------------------------------------------------------------------------
 2037- 2057 (37.12/23.66)	PLDSKTTSDV.LRF.VLEQ.YNAL
 2064- 2087 (26.37/14.58)	PATQDRTSCLpVHFvVLTQlYNAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     208.95|      70|     467|     124|     199|      12
---------------------------------------------------------------------------
  124-  199 (112.16/84.68)	YPMVLKKK.EELKEEEEL...GYDDDFPVAvEVIVGGVRMVYP...SAFVLISQNDLPVPQ.SVAGTGGHITVGQqglgsVKD..P
  606-  685 (96.79/59.09)	YIFTANKKcKQGTEKDSLkknKSEDGFGTK.DVTTPGHSTPVPegkNAMSLFSSTKTDVRQdSAAGRAGSSSLTQ.....VTDlaP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.99|      20|     467|     282|     325|      13
---------------------------------------------------------------------------
  303-  322 (38.73/59.90)	SCSCSRHKLLKRCAVGPSRP
 1723- 1742 (36.26/ 6.02)	SCTDLHGELLETCIVNIALP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.01|      14|      16|    1116|    1130|      14
---------------------------------------------------------------------------
 1116- 1130 (23.36/19.54)	PFASLSFlDYISC.NN
 1135- 1149 (24.66/15.10)	PCVSWSY.DRVQAdNN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20668 with Med13 domain of Kingdom Metazoa
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