<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20667

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMRYTVNIYFSKFIYLYGSLFLVFSRKNSQNCCNFLYFFQAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEELKEEEELGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDLPVPQSVAGTGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAVIGESGGTQSAVSHLGSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPANNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPSRPPTISQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDPPGQKLGLAGIDSSLEVASSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETENLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSDKWWHSYHLPSIDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQMQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPEGKNAMSLFSSTKTDVRQDSAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPTVGTEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTQLTEFKVEVEDGLGSPKPEEIKDFSYVHKVPTLQPFVGSSMFAPLKMLPSQCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQTTFLPQMEGARKSQEPPISLLLLLQNQHTQPFASLSFLDYISCNNRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLAEELVSEWFNQPWGSEESDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQTPPAAAQGQATPGNAGPLASNPGSAAPSAGSAFNPTSNGSSVNPAASSSASGSSVPPASTSASAPIINQISTTSSSGFSGSVGAQNPSAGASSAERTQGNIGCGGDTEPGQSSSQPSQDGQESVTERERIGIPTEPDSADSQAYPPAVVIYMVDPFTYTAEEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIALPNRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKRLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2225
PositionMiddle
OrganismTursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus)
KingdomMetazoa
Lineage
Aromaticity0.08
Grand average of hydropathy-0.373
Instability index58.08
Isoelectric point5.74
Molecular weight245074.96
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20667
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.93|      26|      28|    2083|    2110|       1
---------------------------------------------------------------------------
 2083- 2110 (37.05/27.91)	GsHFQhSRSQGERL...LSREAPEELKQQPL
 2113- 2141 (44.88/24.29)	G.YFV.STAKAENLpqwFWSSCPQAQNQCPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.08|      18|      28|    1881|    1907|       2
---------------------------------------------------------------------------
 1881- 1899 (30.33/34.50)	RSkVSAR..KIGLQKLWEWCI
 1910- 1929 (27.75/ 9.43)	RV.VIGRlgRLGHGELKDWSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     119.87|      27|      28|    1024|    1050|       3
---------------------------------------------------------------------------
 1024- 1050 (48.71/22.11)	PDYLNTPQMNTPVTLNSAAPASNSGAG
 1055- 1078 (44.66/19.64)	P...ATPRFSVPTPRTPRTPRTPRGGG
 1094- 1112 (26.51/ 8.59)	GSPASTPSTTRP..LNSVEPA......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.13|      20|      28|    1146|    1172|       4
---------------------------------------------------------------------------
 1146- 1165 (40.30/34.51)	CICACNMNIK.GADVGLYIPD
 1176- 1196 (33.83/13.59)	CGFSAIMNRKlGYNSGLFLED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.06|      39|     363|     477|     519|       5
---------------------------------------------------------------------------
  479-  519 (67.40/46.46)	SSKHKTTERQEKGDKLQKRPLIPFHhrPSVAEELCMEQDPP
  845-  883 (71.66/37.06)	SSKMPTVGTEDRPLGKDGRAAVPYP..PTVADLQRMFPTPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.06|      18|      20|    1624|    1643|       6
---------------------------------------------------------------------------
 1624- 1643 (28.34/20.02)	GSVGAQNPsaGASSAERTQ.G
 1646- 1664 (31.71/15.98)	GCGGDTEP..GQSSSQPSQdG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.70|      23|      24|    1574|    1596|       7
---------------------------------------------------------------------------
 1557- 1574 (31.21/11.74)	GNA.GPLAS.......NPGSAAPSAG
 1575- 1594 (23.54/ 7.16)	.SAFNPTSNGSS...VNPAASSSA..
 1596- 1621 (32.95/12.77)	GSSVPPASTSASapiINQISTTSSSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.62|      22|     113|     451|     477|       8
---------------------------------------------------------------------------
  451-  477 (29.02/26.02)	VGPsRPPTIS.QPgfsAGpSSSSSLPPP
  567-  589 (39.60/17.27)	ISP.LPPTLSpQP...RG.QETENLDPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.14|      23|      26|    1755|    1780|       9
---------------------------------------------------------------------------
 1755- 1780 (38.99/31.86)	QvfyIQYLKSM..AFSVYCQCR...RPLPTQ
 1782- 1809 (30.15/15.71)	H...IKSLTGFgpAASIEMTLKnpeRPSPIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.10|      20|      22|     963|     983|      10
---------------------------------------------------------------------------
  963-  983 (34.45/20.69)	MFAPLKMLPSQC.LLPLKiPDA
  985- 1005 (34.64/16.65)	LFRPSWAIPPKIeQLPMP.PAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.73|      18|      22|    1244|    1264|      11
---------------------------------------------------------------------------
 1246- 1264 (30.76/21.95)	QHTQPFASLSFlDYISC.NN
 1265- 1283 (30.96/11.69)	RQTLPCVSWSY.DRVQAdNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.03|      16|      22|    1707|    1727|      12
---------------------------------------------------------------------------
 1710- 1727 (27.38/28.62)	SG...NFWLLSLMRC.YteMLD
 1730- 1749 (21.64/ 6.27)	PEhmrNSFILQIVPCqY..MLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.95|      23|      24|    1390|    1412|      13
---------------------------------------------------------------------------
 1390- 1412 (41.19/29.38)	SPEPLPIPTLLVGY....DKDFLTISP
 1413- 1439 (37.75/26.09)	FSLPFWERLLLDPYgghrDVAYIVVCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.07|      20|      24|    1986|    2005|      14
---------------------------------------------------------------------------
 1986- 2005 (32.55/19.90)	VFGRSTALNMQSSQLNTPQD
 2011- 2030 (31.53/18.99)	ILVFPTSSTIQVAPANYPNE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.49|      21|      28|    2171|    2191|      15
---------------------------------------------------------------------------
 2171- 2191 (37.12/22.88)	PLDSKTTSDV.LRF.VLEQ.YNAL
 2198- 2221 (26.37/14.15)	PATQDRTSCLpVHFvVLTQlYNAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.67|      18|      28|    2034|    2056|      16
---------------------------------------------------------------------------
 2033- 2055 (25.96/28.06)	F........SPNNDdmfvDLPFPDDmDNDIG
 2056- 2081 (27.71/12.89)	IlmtgnlhsSPNSS....PVPSPGS.PSGIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.16|      27|      61|      12|      38|      17
---------------------------------------------------------------------------
   12-   38 (51.17/36.12)	FIY.LYGSLFLVFSRKNSQNCCNFLYFF
   75-  102 (48.99/34.22)	FIRcLQANLLCVWRRDVKPDCKELWIFW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.44|      11|      17|     618|     629|      18
---------------------------------------------------------------------------
  618-  629 (15.05/11.99)	GQRlPLMAEVSE
  635-  645 (20.39/11.19)	GIR.PSNPESSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.15|      26|    1264|     178|     204|      21
---------------------------------------------------------------------------
  178-  204 (45.39/36.62)	LSCAFTFFlHGESNVCTSVEIAQHQPI
 1445- 1470 (48.77/34.39)	LEGAKTFF.RDLSAVYEMCRLGQHKPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.43|      12|      26|     378|     389|      23
---------------------------------------------------------------------------
  378-  389 (22.36/12.56)	KRSGKIPPKLHN
  407-  418 (21.06/11.34)	KRSQMSTPTLEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.89|      22|     394|     355|     377|      24
---------------------------------------------------------------------------
  355-  376 (39.90/26.76)	GGTQSAVSHLGSQDGGMITMHS
  900-  921 (37.99/19.44)	GISSETVTALGMMESPMVSMVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.13|      17|      17|     786|     802|      25
---------------------------------------------------------------------------
  778-  794 (28.45/19.01)	TPVPEGKNAMSLFSSTK
  795-  811 (27.68/18.26)	TDVRQDSAAGRAGSSSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.41|      14|      17|     240|     255|      26
---------------------------------------------------------------------------
  240-  253 (24.00/17.26)	YKMSDPATRKLIEE
  258-  271 (23.41/ 8.28)	YPMVLKKKEELKEE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20667 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CAVGPSRPPTISQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDPPGQKLGLAGIDSSLEVASSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETENLDPPSVPVNPALYG
2) ECILNRTQSKRSQMSTPTLEEEPANNPATWDFVDPT
3) GILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPE
4) GTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPEGKNAMSLFSSTKTDVRQDSAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPTVGTEDRPLGKDGRAAVP
5) KYQTPPAAAQGQATPGNAGPLASNPGSAAPSAGSAFNPTSNGSSVNPAASSSASGSSVPPASTSASAPIINQISTTSSSGFSGSVGAQNPSAGASSAERTQGNIGCGGDTEPGQSSSQPSQDGQESVTERERIGIPTEPDSA
6) SVAGTGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAVIGESGGTQSAVSHLGSQDGGMITMHSPKRSGKIPPKLH
7) VGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQ
449
398
2055
751
1542
312
1018
599
433
2103
867
1683
388
1115










Molecular Recognition Features






MoRF SequenceStartStop




1) RFKIW
694
698