<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20663

Description mediator of RNA polymerase II transcription subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAITETKVKKRHVIDPFMEWTQIITKYLWEQLQKMAEYYRPGPSGSGGCGSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGMSSHSSHVMSAQSTSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPERKEAEGSSSSKLEVRGLFLALDHFLYFSFSFPPISSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPALLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHTNPGSISHLSYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPPYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPADPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMIGTMTPLGAQGVQAGVRSASILPEQQQQQQQQQQQQQQQQQQQAHQQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length1316
PositionKinase
OrganismTursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus)
KingdomMetazoa
Lineage
Aromaticity0.07
Grand average of hydropathy-0.549
Instability index57.65
Isoelectric point8.59
Molecular weight147382.74
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20663
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     116.67|      12|      15|    1235|    1246|       1
---------------------------------------------------------------------------
 1116- 1127 (20.24/ 6.25)	PQGQRLRQQLQQ
 1235- 1246 (24.61/ 9.29)	EQQQQQQQQQQQ
 1251- 1262 (22.36/ 7.73)	QQQQAHQQQQQQ
 1266- 1277 (24.48/ 9.20)	PQPQPQSQPQFQ
 1278- 1289 (24.98/ 9.55)	RQGLQQTQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     191.98|      29|      29|     955|     983|       2
---------------------------------------------------------------------------
  634-  657 (34.42/12.31)	PPSPF..DDPA....D...DPERKEA.EGSSSSK..
  955-  983 (56.23/24.73)	PPEDE..EPPA....PALLEPEKKAP.EPPKTDKPG
  986- 1006 (31.75/10.79)	PPSTE..E............RKKKST.KGKKRSQPA
 1015- 1037 (30.04/ 9.81)	GPGRS..GPYGvtvpPDLLHHT...........NPG
 1059- 1086 (39.54/15.22)	PAGGPrvDPYR....PVRL.PMQKLPtRPPY...PG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      81.71|      17|      36|    1138|    1154|       3
---------------------------------------------------------------------------
 1138- 1154 (32.04/13.32)	HQMT.PS..SSYGLQTSQGY
 1164- 1183 (20.56/ 6.13)	QQHTgPAdpTRHLQQRPSGY
 1185- 1201 (29.11/11.49)	HQQA.PT..YGHGLTSTQRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     319.73|      95|     339|     160|     267|       4
---------------------------------------------------------------------------
  160-  267 (153.65/126.56)	IKMTCAYyaAITeTKVKKRHvidpfmeWTQIITKYLwEQLQKMAEYYRPGPS......GSGGCGS...TIGPLPHDVEV....AIRQWDYNEKLamFM.FQDGML.......DRHEFLTWVLECFEKIR
  451-  498 (43.66/17.97)	...............................................................GF...TIGRVLHTLEVldshSFERSDFSNSL.......DSLC.......NRIFGLGPSKDGHE.IS
  505-  606 (122.42/72.09)	VSLLCEW..AVS.CKRSGRH.......RAMVVAKLL.EKRQAEIEAERCGESeaadekGSIASGSlsaPSAPIFQDV.......LLQ.........FLdTQAPMLtdprsesERVEFFNLVLLFCELIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.25|      22|      24|     762|     784|       5
---------------------------------------------------------------------------
  745-  769 (30.64/16.78)	LRLNL.VGGmfdTVQRSTQQTTEWAV
  770-  792 (31.61/21.97)	LLLEIiISG...TVDMQSNNELFTTV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.82|      15|      18|     873|     890|       6
---------------------------------------------------------------------------
  873-  890 (18.50/24.50)	NKIAGFDsIFkkEGLQVS
  893-  907 (30.32/22.27)	QKISPWD.LF..EGLKPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.52|      26|     343|     337|     363|       7
---------------------------------------------------------------------------
  337-  362 (49.48/25.81)	PPTSSTPSTPFSDLLMCPQHRPLVFG
  385-  410 (45.05/19.02)	TDSRIKTGSPLDHLPIAPSNLPMPEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.79|      32|      41|      69|     104|       9
---------------------------------------------------------------------------
   69-  104 (49.76/40.50)	ISSNFSSIIAEKlrcnTLPDTGRRKPQVNQKDN.F.WL
  113-  146 (46.02/27.04)	INTWFTDLAGTK....PLTQLAKKVPIFSKKEEvFgYL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20663 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AYYLEPLPLPPEDEEPPAPALLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHTNPGSISHLSYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPPYPGVLPTTMTGVM
2) KRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKN
3) LEPSSYKTSVYRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPADPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMIGTMTPLGAQGVQAGVRSASILPEQQQQQQQQQQQQQQQQQQQAHQQQQQQAAPPQPQPQSQPQFQRQGLQQTQ
946
15
1098
1096
61
1285










Molecular Recognition Features






MoRF SequenceStartStop




1) IFGRY
2) MAAFG
1312
1
1316
5