<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20660

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSSSFVPNGASLEDCHCNLFCLADLTGIKWKRYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPNFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILSPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPVSSCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSSVGSSHCSASCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSAQKWITFSSVSDGFSSDSTSHHGGKIPRKLANHVVDRVWQECNLNRAQNKRKYSASSGGLCEEETADKVASWDFVEATQRTNCSCLRHKNLKPRNPGQQGQAPTLSQQQQVLPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPIEDRIDSLSQSFPAQFQEAVEPTIYVGTAVNLEEDEANIAWKYYKVPKKKDLEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKPLKVSDELVQQYQIKNQYLSAIASDSEQEPKIDPYAFVEGDEEFLFPDKKDRQNNEREAGKKHKVEDVPSSVTVLSHEEDAMSLFSPSIKQDAPRPTSHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKSANGSDDKSSCKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTPGGTVLEGNSSSIGAQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQVLVGCSMFAPLKTLPSQCLPAIKLPEECIYRQSWTVGKLELLPSGPTMPFIKEGDGSTMDQEYGPAYTPQTHASFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTECGKEAEKRFEALRATSAEHVNGGLKESEKLPDELILLLQDQCTNLFSPFGAADQDPFPKIGITNNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDFDFLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPISRLLTDGIMRVGSTASKKLSEKLVAEWFSQAADGNSEAFSKLKLYAQVCRYDLGPYLASQPLDSSLLSQPNLVAPTSQPLITPPQMTSTGNANIPSATLASTASSTVTMTSGVAISSSVATANSTLTTTSASSSSSSNLNSGMSSNKLPSFPPFGSMNSSVAGSMSTQASTVQNGQLGGQPPSALQTAGISGESSSIPSQPHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENKDESTNSSNVWTLGLLRCFLEMVQTLPPHVKSTVSVQIVPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALKSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKGSARRFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDAGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2174
PositionMiddle
OrganismTursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Delphinidae> Tursiops.
Aromaticity0.08
Grand average of hydropathy-0.395
Instability index53.35
Isoelectric point5.39
Molecular weight239408.45
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20660
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     398.27|     103|     320|     473|     599|       1
---------------------------------------------------------------------------
  487-  591 (178.23/111.39)	GMDTDSA....SQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDV.VDEGVTKTPSTPQSQHFYQmPTPDPLVPSkPIEDRIDSLSQSFPAQFQ
  985- 1066 (118.44/51.27)	GMPPSSAppsnSGAGILPSP.STPRFPTPRTPRTPRTPR..GAGGPASAQ.GSVKYENSDL.YSP..ASTPSTCRPLNSVE.PATVPSIP....................
 1465- 1525 (65.62/23.17)	......A....SQPL.DSSLLSQPNLVAPTSQPLITPPQMTSTGNANIPSATLASTASSTVtMTSGVAISSS......................................
 1749- 1785 (35.97/ 6.70)	....................................................................KSPDRPECIRLY...TP.PFILA.PVKDKQTELGETFGEAGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.52|      16|      28|    1096|    1111|       2
---------------------------------------------------------------------------
 1096- 1111 (31.84/18.48)	CVCN....MNIK.GADVGVYI
 1122- 1142 (22.68/11.10)	CTCGfsavMNRKfGNNSGLFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.23|      45|     534|    1260|    1310|       3
---------------------------------------------------------------------------
 1260- 1310 (76.67/63.08)	CL.HP..WskrndVSMQCSqDILRMLLSLQPVLQD....AIQKKRTVRPWGVQGPLTW
 1795- 1846 (70.56/43.25)	CLsHDqrW.....ILASCT.DLYGELLETCIINIDvpnrARRKKGSARRFGLQKLWEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     215.26|      72|     534|     608|     708|       4
---------------------------------------------------------------------------
  309-  417 (94.85/57.51)	HQVPaSTRDpamssVTLTPPTSPeevqtvdpqsaqkwitfssvSDGFSSDSTSHHG.............GKIPRKLANHVVDrvwqecnlnRAQNKRKYSASSGGLCEEEtaDKVASWDFVE
  618-  702 (120.41/114.20)	YKVP.KKKD.....LEFLPPQLP....................SDKFKDDPVGPFGqesvtsvtelmvqCKKPLKVSDELVQ.........QYQIKNQYLSAIASDSEQE..PKIDPYAFVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     212.15|      65|     320|    1617|    1681|       5
---------------------------------------------------------------------------
 1617- 1681 (117.37/80.52)	MDRDKVGIPTDGD.SHAITYPPAIVVYIIDP.FTYENKDESTNSSNVWTLGL.LRCFLEMVQTLPPHV
 1944- 2011 (94.78/63.23)	MQTSQLNTPQDTScTHILVFPTSASVQVASAtYTTENLDLAFNPNNDGADGMgIFDLLDTGDDLDPDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.31|      13|     532|     913|     927|       6
---------------------------------------------------------------------------
  913-  925 (24.30/18.17)	GCSMFAPLKTLPS
  941-  953 (23.01/ 8.00)	QSWTVGKLELLPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.31|      11|      19|    1322|    1332|      12
---------------------------------------------------------------------------
 1322- 1332 (22.98/12.38)	YGTD...ESPEPLP
 1340- 1353 (17.33/ 7.14)	YDFDflvLSPFALP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.50|      19|     261|     182|     203|      13
---------------------------------------------------------------------------
  182-  203 (30.40/28.25)	QHQPVYllsEEHITLAQQ..SNSP
  448-  468 (29.11/17.97)	QQQQVL...PKHKTNEKQekSEKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.33|      24|     857|      20|      44|      14
---------------------------------------------------------------------------
   20-   44 (42.00/28.09)	FCLADLTGIKWKRYVWQgPTSAPIL
  888-  911 (46.33/26.41)	FCSPKPSEIKDFSYVYK.PENCQVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.70|      17|      18|    1572|    1588|      16
---------------------------------------------------------------------------
 1572- 1588 (28.92/15.88)	MSTQASTVQNGQLGGQP
 1592- 1608 (27.78/14.94)	LQTAGISGESSSIPSQP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20660 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CSCLRHKNLKPRNPGQQGQAPTLSQQQQVLPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPIEDR
2) DLDNLFNSDEDELTPGSKKSANGSDDKSSCKES
3) GPTMPFIKEGDGSTMDQEYGPAYTPQTHASFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENS
4) GSPVHSPGSHYPHGGDAGKGQGTDRLLSTESH
5) STLTTTSASSSSSSNLNSGMSSNKLPSFPPFGSMNSSVAGSMSTQASTVQNGQLGGQPPSALQTAGISGESSSIPSQPHPDVSESTMDRDKVGIPTDGD
424
782
954
2021
1531
578
814
1039
2052
1629










Molecular Recognition Features






MoRF SequenceStartStop




1) AFVEGDE
699
705