<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20659

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSSSFVPNGASLEDCHCNLFCLADLTGIKWKRYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPNFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILSPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPVSSCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSSVGSSHCSASCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTACSFLFSVDPQSAQKWITFSSVSDGFSSDSTSHHGGKIPRKLANHVVDRVWQECNLNRAQNKRKYSASSGGLCEEETADKVASWDFVEATQRTNCSCLRHKNLKPRNPGQQGQAPTLSQQQQVLPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPIEDRIDSLSQSFPAQFQEAVEPTIYVGTAVNLEEDEANIAWKYYKVPKKKDLEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKPLKVSDELVQQYQIKNQYLSAIASDSEQEPKIDPYAFVEGDEEFLFPDKKDRQNNEREAGKKHKVEDVPSSVTVLSHEEDAMSLFSPSIKQDAPRPTSHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKSANGSDDKSSCKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTPGGTVLEGNSSSIGAQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQVLVGCSMFAPLKTLPSQCLPAIKLPEECIYRQSWTVGKLELLPSGPTMPFIKEGDGSTMDQEYGPAYTPQTHASFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTECGKEAEKRFEALRATSAEHVNGGLKESEKLPDELILLLQDQCTNLFSPFGAADQDPFPKIGITNNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDFDFLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPISRLLTDGIMRVGSTASKKLSEKLVAEWFSQAADGNSEAFSKLKLYAQVCRYDLGPYLASQPLDSSLLSQPNLVAPTSQPLITPPQMTSTGNANIPSATLASTASSTVTMTSGVAISSSVATANSTLTTTSASSSSSSNLNSGMSSNKLPSFPPFGSMNSSVAGSMSTQASTVQNGQLGGQPPSALQTAGISGESSSIPSQPHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENKDESTNSSNVWTLGLLRCFLEMVQTLPPHVKSTVSVQIVPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALKSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKGSARRFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDAGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2181
PositionMiddle
OrganismTursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Delphinidae> Tursiops.
Aromaticity0.08
Grand average of hydropathy-0.388
Instability index53.42
Isoelectric point5.39
Molecular weight240164.33
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20659
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    1075.55|     281|     320|     333|     652|       1
---------------------------------------------------------------------------
  104-  326 (212.20/103.42)	................................................................................................................DGVW.ENGLSYECRTLLFKAVHNLLerClMNRNFVRIGKW.FVKPYE.........KDEKPINKSEHLSCSftfFLHGDSNVCTSVEINQHQpvyllsEEhitlaqqSNS.PFQVILSPF..........GLNgtltgqafkmSDSATKKLI..........GEWKQfYPVSS..CL....K.....EMSEE...KQEdmdwEDDSLAAVEVLVAGVRMIyPAcfvlVPQS.........DIPTPS...S.VGSSHCSASCLGVHQ.VPASTRDPAMSSVTLT
  327-  608 (408.50/270.17)	PPTSPEE.......................................................vQTACSFLFSVDPQSAQKWitfssvsdgfssdstshhggkiprklanhvvDRVWqECNLNRAQNKRKYSASSGGL..C.EEETADKVASWDFVEATQRTNCSCLRHKNLKPRNPGQQGQAP...TLSQQQQVLPKHKTNEKQ......EK.......SEK.PQKRPLTPFHHRVSVSDDVGMD..........TDSASQRLVISAPDSQVRFSNIRT.NDVAK..TP....QMHGT.EMANS...PQP....PPLSPHPCDVVDEGVTKT.PS....TPQS..QH...FYQMPTPD...PLVPSKPIEDRIDSLSQSFPAQFQEAVEPTIYVG
  609-  898 (370.94/215.36)	TAVNLEEDeaNIAWKYYKVPKkkdLEFLP..PQLP....SD.KFKDDPVGPfgqesvtsvtelMVQCKKPLKVSDELVQQY...........................................QIKNQYLSAIASD..S.EQE..PKIDPYAFVEGDEEFLFPDKKDRQNNEREAGKKHKVE...DVPSSVTVLS.HEEDAMS......LF.......SPSiKQDAP.RPTSHARPPSTSLIYD..........SD.....LAVSYTDLDNLFN...S.DEDEL..TPgskkSANGS.DDKSSckeSKT....GNLDPLSC.ISTADLHKM.YP....TPPSleQHimgFSPMNMNNkeyGSMDTTPGGTVLEGNSSSIGAQFKIEVDEGFCSP
  936- 1014 (83.91/38.89)	PAIKLPEE..CIYRQSWTVGK...LELLPsgPTMPfikeGDgSTMDQEYGP..........................................................................................................................................................................................................................................ayTP....QTHASfGMPPS...SAP....PSNS.......GAGILPS.PS....TP......................................................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.29|      14|      16|    1516|    1531|       2
---------------------------------------------------------------------------
 1516- 1531 (20.36/19.89)	TASSTVTMTSgvAISS
 1535- 1548 (24.93/16.02)	TANSTLTTTS..ASSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     256.10|      78|     326|    1624|    1706|       3
---------------------------------------------------------------------------
 1624- 1706 (134.61/81.58)	MDRDKVGIPTDGD.SHAITYPPAIVVYIID.PFTYENKDESTNSSNVWTLGL.LRCFLEMVQTLPPHVkstvsVQIVPCQYLLQPV
 1951- 2031 (121.50/65.34)	MQTSQLNTPQDTScTHILVFPTSASVQVASaTYTTENLDLAFNPNNDGADGMgIFDLLDTGDDLDPDI.....INILPASPTGSPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.78|      13|      16|    1034|    1046|       4
---------------------------------------------------------------------------
 1034- 1046 (23.30/14.49)	PASAQGSVKYENS
 1051- 1063 (25.48/16.79)	PASTPSTCRPLNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.66|      25|     417|    1479|    1504|       5
---------------------------------------------------------------------------
 1479- 1504 (43.10/26.63)	SLLSqPNLVAPTSQ.PLITPPQMTSTG
 1915- 1940 (40.57/20.52)	SILS.ACLVAMEPQgSFVIMPDSVSTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.31|      11|      20|    1329|    1339|       6
---------------------------------------------------------------------------
 1329- 1339 (22.98/12.05)	YGTD...ESPEPLP
 1347- 1360 (17.33/ 6.98)	YDFDflvLSPFALP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     347.62|     104|     855|    1200|    1308|       7
---------------------------------------------------------------------------
 1200- 1308 (169.68/121.02)	QDQCTNLF.SPFGAADQDPFPKIGITNNWVRVEERDCCNDCYLALEHGRQFmdNMSGGKVDEaLVKSSCLHPWSKrNDVSmQCSQDILRMLLSLQPVLQD.AIQKKRTVRP
 2059- 2164 (177.94/108.15)	HDEVTNILqQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHL..HVPSVQSDE.LLHSKHSHPLDS.NQTS.DVLRFVLEQYNALSWLTCDpAIQDRRSCLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.94|      23|      37|    1763|    1786|      11
---------------------------------------------------------------------------
 1763- 1786 (38.36/27.91)	CIRlYTPPFILAPVKDKQTELGET
 1802- 1824 (43.59/27.35)	CLS.HDQRWILASCTDLYGELLET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.56|      27|      29|    1840|    1866|      12
---------------------------------------------------------------------------
 1832- 1863 (46.38/27.32)	PNRarrkkGSARRFGLQKLWEW.C.LGLVQMSSL
 1864- 1895 (39.18/21.93)	PWR..vviGRLGRIGHGELKDWsClLSRRNLQSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20659 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CLRHKNLKPRNPGQQGQAPTLSQQQQVLPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPIEDR
2) DLDNLFNSDEDELTPGSKKSANGSDDKSSCKES
3) GPTMPFIKEGDGSTMDQEYGPAYTPQTHASFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENS
4) GSPVHSPGSHYPHGGDAGKGQGTDRLLSTESH
5) STLTTTSASSSSSSNLNSGMSSNKLPSFPPFGSMNSSVAGSMSTQASTVQNGQLGGQPPSALQTAGISGESSSIPSQPHPDVSESTMDRDKVGIPTDGD
433
789
961
2028
1538
585
821
1046
2059
1636










Molecular Recognition Features






MoRF SequenceStartStop




1) AFVEGDE
706
712