<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20658

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMNLEDIMPSEISQSQKDILYDPTYASEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILSPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPVSSCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSSVGSSHCSASCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTACSFLFSVDPQSAQKWITFSSVSDGFSSDSTSHHGGKIPRKLANHVVDRVWQECNLNRAQNKRKYSASSGGLCEEETADKVASWDFVEATQRTNCSCLRHKNLKPRNPGQQGQAPTLSQQQQVLPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPIEDRIDSLSQSFPAQFQEAVEPTIYVGTAVNLEEDEANIAWKYYKVPKKKDLEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKPLKVSDELVQQYQIKNQYLSAIASDSEQEPKIDPYAFVEGDEEFLFPDKKDRQNNEREAGKKHKVEDVPSSVTVLSHEEDAMSLFSPSIKQDAPRPTSHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKSANGSDDKSSCKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTPGGTVLEGNSSSIGAQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQVLVGCSMFAPLKTLPSQCLPAIKLPEECIYRQSWTVGKLELLPSGPTMPFIKEGDGSTMDQEYGPAYTPQTHASFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTECGKEAEKRFEALRATSAEHVNGGLKESEKLPDELILLLQDQCTNLFSPFGAADQDPFPKIGITNNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDFDFLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPISRLLTDGIMRVGSTASKKLSEKLVAEWFSQAADGNSEAFSKLKLYAQVCRYDLGPYLASQPLDSSLLSQPNLVAPTSQPLITPPQMTSTGNANIPSATLASTASSTVTMTSGVAISSSVATANSTLTTTSASSSSSSNLNSGMSSNKLPSFPPFGSMNSSVAGSMSTQASTVQNGQLGGQPPSALQTAGISGESSSIPSQPHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENKDESTNSSNVWTLGLLRCFLEMVQTLPPHVKSTVSVQIVPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALKSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKGSARRFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDAGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2050
PositionMiddle
OrganismTursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Delphinidae> Tursiops.
Aromaticity0.07
Grand average of hydropathy-0.388
Instability index54.45
Isoelectric point5.28
Molecular weight224747.81
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20658
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     948.19|     301|     337|    1201|    1536|       1
---------------------------------------------------------------------------
  767-  865 (76.99/37.41)	.........................................PKPSEiKDFSY.VYKPENCQVLVGC.SMFAPLKTLPSQC............................................................................................................................................................................................................................................lpaiklpeeciyrqswtvGKLELLPSGPtMPFIKEgdgSTMDQE.YGpayTPQ....THAsFGMPPS.......................
 1209- 1536 (474.59/370.16)	IPTflLGYDFDFL..V..LSPFA........LPywERLMLEPYGSQ.RDIAYvVLCPENEALLNGAKSFFRDLTAIYESCR..LGQHRPISRL..LTDGIMRVGSTASKKLSE..KLVAEWF.......SQAADGNS..EAFSKLK.LYAQVC.RYDLGPYLAS.QPLDSSLLSqpnlvaptsqplitppqmTSTGNANIPS.ATLASTASSTVTMTS......GVAISSSVAT..........ANSTLTTTSaSSSSSSNLNSgmSSNKLPSFPPFGSMNSSVAGSMSTQASTVQNGQlGG..QPPSALQTAGIS..................GESSSIPSQP.HPDVSE...STMDRDKVG...IPTDGD.SHA.ITYPPAIVVYIIDP.FTYENKDESTNSSN
 1537- 1865 (396.60/243.13)	VWT..LGLLRCFLemVqtLPPHVkstvsvqiVP..CQYLLQPVKHE.DRQIY......TQHLKSLAFSAF.......TQCRrpLPTSTNVKTLtgFGPGLAMETALKSPDRPEciRLYTPPFilapvkdKQTELGETfgEAGQKYNvLFVGYClSHDQRWILAScTDLYGELLE..................TCIINIDVPNrARRKKGSARRFGLQKlwewclGLVQMSSLPWrvvigrlgriGHGELKDWS.CLLSRRNLQS..LSKRLKDMCRMCGISAADSPSILSACLVAMEPQ.GSfvIMPDSVSTGSVF..................GRSTTL...............NMQTSQLN...TPQDTScTHI.LVFPTSASVQVASAtYTTENLDLAFNPNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.07|      49|     213|     378|     523|       2
---------------------------------------------------------------------------
  409-  471 (75.51/63.71)	PPPLSphpcdvvDEGVTKTPSTPqsqhfyQMPTP.DPLVPSKP..............IEDRiDSLS.QSFPAQFQ..EAVE
  868-  934 (69.56/20.31)	PPSNS.......GAGILPSPSTP......RFPTPrTPRTPRTPrgaggpasaqgsvkYENS.DLYSpASTPSTCRplNSVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.90|      35|     857|    1069|    1177|       4
---------------------------------------------------------------------------
  649-  683 (61.40/12.99)	DSDLAVSYTD..LDNLFNSDEDE.......LTPGSKK...SANGSDD
 1107- 1153 (52.50/21.59)	DCYLALEHGRqfMDNMSGGKVDEalvksscLHPWSKRndvSMQCSQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.16|      24|      43|    1866|    1891|      24
---------------------------------------------------------------------------
 1866- 1891 (34.12/43.15)	DGADGMGIFDLLDTgDDLDpDIINIL
 1912- 1935 (42.04/36.65)	DAGKGQGTDRLLST.ESHD.EVTNIL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20658 with Med13 domain of Kingdom Metazoa
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