<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20654

Description mediator of RNA polymerase II transcription subunit 14 isoform X2
SequenceMLRLPGGAASDRLRERSFSAAPAPLPRPPSSPLPPPPPPLTPVPGAGGLVATWGRASAAGARLPVQRRPGGSKRRRRRRRRRRRRRRLRPRPHRRGDRAPGRETRGPHLVPLRQARFCAAMAPVQLENQLVPPGGGGGGSSGPASAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDHQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYQYYLMSVNAADREDSPVMALLLLQFKENIQELVYRTKNGKQPRSSTKRKLSDDLCPVEPKKTKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHKGVQMEGDGFSHAIRLLKIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPTHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGSSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
Length1529
PositionTail
OrganismTursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Delphinidae> Tursiops.
Aromaticity0.06
Grand average of hydropathy-0.259
Instability index58.31
Isoelectric point9.58
Molecular weight169778.63
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20654
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.68|      36|      58|    1132|    1188|       1
---------------------------------------------------------------------------
 1153- 1196 (59.08/25.65)	QSPSMmhtqSPGtlDPS..SPYTMVSPSGRAG........NWPGSPqvSGPS...PA
 1198- 1248 (49.60/28.06)	RMPGM....SPA..NPSlhSPVPDASHSPRAGtssqtmptNMPPPRklPQRSwaaSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.39|      15|      18|     666|     680|       2
---------------------------------------------------------------------------
  666-  680 (27.47/18.80)	QYYIV.VEMLEVPNKP
  686-  701 (22.92/14.39)	QYYLMsVNAADREDSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.28|      19|      58|     251|     269|       3
---------------------------------------------------------------------------
  251-  269 (30.29/19.92)	TADRLASLARDALVHARLP
  284-  298 (26.77/16.58)	SYPRLPTCIRDKII....P
  310-  328 (31.22/20.81)	TLHQLNQILRHRLVTTDLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     288.53|      62|      62|       5|      66|       4
---------------------------------------------------------------------------
    5-   63 (109.85/41.96)	..........PGGAASDRLRERSFSAAPAPLPRPPS........SPLPPP.....P..PPLTPVPGAGGLVATWGRASAAGARL
   64-  122 (76.79/27.16)	PVQ.....rrPGGSKRRRRRRRRRRRRRRLRPRPHR........RGDRAPgretrG..PHLVP......LRQA..RFCAAMA..
  123-  170 (70.21/24.22)	PVQlenqlvpPGGGGGG.......SSGPA......S........AP..AP.....P..P.....PGA.AVAAAAAAAASPGYRL
 1093- 1136 (31.68/ 6.97)	...................RRRSVNEDDNP.PSPIGgdmmdsliSQLQPP.....PqqQPFPKQPGSSG...............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.80|      30|      31|     365|     394|       5
---------------------------------------------------------------------------
  365-  394 (48.45/32.42)	RLLKLEILVEDKETGDGRALVH....SMQINFIH
  395-  428 (45.35/29.85)	QLVQSRLFADEKPLQDMYNCLHsfclSLQLEVLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.38|      29|      91|     883|     911|       6
---------------------------------------------------------------------------
  883-  911 (52.02/36.38)	EMFLND...................WNSIARLYECVLEFARSLPDI...PT
  918-  960 (24.10/12.22)	EVRVYNyrklilcygttkgssisiqWNSIHQKFHISLGTVG..PN......
  976- 1006 (40.26/26.20)	EMF.NK...................TPNVVQLLQVLFDTQAPLNAInklPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.41|      31|      31|     185|     215|       7
---------------------------------------------------------------------------
  185-  215 (49.64/32.95)	LMVLTDLLPRKSDVERKIEIVQFASRTRQLF
  218-  248 (51.77/34.68)	LLALVKWANNAGKVEKCAMISSFLDHQAILF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     202.48|      60|      63|     739|     801|       8
---------------------------------------------------------------------------
  739-  801 (101.93/97.17)	LCPVEPKKTKRSGEMCAFNKVL..AHFVAMCDTNMPFVGlrlELSNLEIPHKGVQMEGDGFSHAI
  803-  864 (100.55/86.12)	LLKIPPCKGVNEETQKALDRSLldCTFRLQGRNNRTWVA...ELVFANCPLNGTSTREQGPSRHV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.19|      19|      24|    1438|    1461|       9
---------------------------------------------------------------------------
 1443- 1461 (32.58/24.12)	QLTQKTSVPPQEPVSIIVP
 1469- 1487 (31.61/11.75)	GTTQQADIPRQQNSSVAAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.60|      14|      37|    1322|    1336|      12
---------------------------------------------------------------------------
 1322- 1336 (21.47/15.66)	LKCRVALSP.KTNqTL
 1360- 1374 (22.14/11.00)	FETRVAGPPfKAN.TL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.38|      11|     114|    1019|    1032|      13
---------------------------------------------------------------------------
 1019- 1029 (20.72/16.18)	AYQCFSILPQS
 1039- 1049 (22.66/ 8.19)	NMYCIDIYCRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.42|      13|      30|    1401|    1415|      15
---------------------------------------------------------------------------
 1401- 1415 (21.56/22.68)	PdqATQLKWNVQFCL
 1430- 1442 (22.86/15.21)	P..AVVLKSKMLFFL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20654 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LENQLVPPGGGGGGSSGPASAPAPPPPGAAVAAA
2) MLRLPGGAASDRLRERSFSAAPAPLPRPPSSPLPPPPPPLTPVPGAGGLVATWGRASAAGARLPVQRRPGGSKRRRRRRRRRRRRRRLRPRPHRRGDRAPGRETRGPHLVPLRQ
3) NQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGSSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWA
126
1
1089
159
114
1245










Molecular Recognition Features






MoRF SequenceStartStop




1) LRERSF
2) WGRASAAGARL
13
53
18
63