<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20653

Description mediator of RNA polymerase II transcription subunit 14 isoform X1
SequenceMLRLPGGAASDRLRERSFSAAPAPLPRPPSSPLPPPPPPLTPVPGAGGLVATWGRASAAGARLPVQRRPGGSKRRRRRRRRRRRRRRLRPRPHRRGDRAPGRETRGPHLVPLRQARFCAAMAPVQLENQLVPPGGGGGGSSGPASAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDHQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYQYYLMSVNAADREDSPVMALLLLQFKENIQELVYRTKNGKQPRSSTKRKLSDDLCPVEPKKTKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHKGVQMEGDGFSHAIRLLKIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPTHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGSSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
Length1573
PositionTail
OrganismTursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Delphinidae> Tursiops.
Aromaticity0.06
Grand average of hydropathy-0.254
Instability index58.79
Isoelectric point9.60
Molecular weight173935.16
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20653
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     431.89|      61|      62|    1172|    1232|       1
---------------------------------------------------------------------------
   22-   59 (64.70/18.46)	.........PAPL...............PR.P...PSSPLPPPPPP...LTPV.PGA..................................................................GGL.............VATWG.RAS..AA
   60-  142 (51.59/13.40)	GARLpvqrrPGGSkrrrrrrrrrrrrrrLR............PRPHRRG.DRA.PGRE.....TRGP...........................................HlvplrqarfcaaMAP..VQLENQ.L...VPPGG.GGGgsSG
 1103- 1165 (72.35/21.41)	PPSP.....IGGD...............M.MD..SLISQL.QPPPQQQPFPKQ.PGSSgayplTSPP........................................tsyH............STVnqSPSMMHTQ....SPGN........
 1172- 1228 (103.39/33.39)	.........PSGA...............LRAP..SPASFVPTPPPSSHGISIG.PGAS.....FASP...........................................H............GTL..DPSSPYTM...VSPSG.RAG..NW
 1229- 1288 (82.20/25.21)	PGSP.qvsgPSPA...............TRMPgmSPAN......PSLH..SPV.PDAS.....HSPR...........................................A............GTS..SQTMPTNM...PPPRKlPQR..SW
 1289- 1392 (57.66/15.74)	AASI.....PT.................ILTH..SALNILLLPSPTP.GLVPGlAGSY.....LCSPlerflgsvimrrhlqriiqqetlqlinsnepgvimfktdalkcR............VAL..SPKTNQTLqlkVTPEN..AG..QW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     360.92|     112|     119|     254|     372|       3
---------------------------------------------------------------------------
  149-  279 (77.79/51.30)	....................PPPPGAAVAAAAAaaaspgyrLS.TLIEFLLHRayselMVLTDL.......LPRksdverkieivqfasrtrqlfvrlLALVKWANnaGKVeKCAMISSFldhQA.ILFV..DTAD...............................rLASLARDAL....VHARlpSFAIPYAIDV
  280-  396 (179.19/126.44)	LTTGSYP..RLPTCIRDKIIPPDPITKIEKQAT........LH.QLNQILRHR.....LVTTDL.......PPQ........................LANLTVAN..GRV.KFRVEGEF...EA.TLTVMGDDPDV..PwrllkLEIL..............vedK.ETGDGR.AL....VH....SMQINFIHQL
  401-  527 (103.94/62.63)	LFADEKPlqDMYNCLHSFCLS......LQLE.V........LHsQTLMLIRER.....W..GDLvqveryhAGK........................CLSLSVWN..QQV.LGRKTGTA...SVhKVTIKIDENDVskP.....LQIFhdpplpasdsklveramK.IDHLSIEKLlidsVHAR............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     186.20|      41|     123|     882|     922|       4
---------------------------------------------------------------------------
  882-  922 (71.67/47.51)	VEMF.LNDWNSIARLYECVLEFARSLPD...I...PTHLNI.FSE...VRVY
  937-  974 (44.79/26.50)	SSIS.I.QWNSIHQKFHISLGTVG..PNsgcS...NCHNTI.LHQ...L...
  976- 1006 (25.02/11.04)	.EMF..NKTPNVVQLLQVLFDTQAPLNA...InklPT...............
 1007- 1046 (44.72/26.44)	VPMLgLTQRTNTA..YQC...FS.ILPQ...S...STHIRLaFRNmycIDIY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.06|      24|      24|    1482|    1505|       5
---------------------------------------------------------------------------
 1481- 1504 (39.65/20.10)	KMLFFL..QLTQKTSVPPQEPVSIIV
 1505- 1530 (34.41/16.40)	PIIYDMasGTTQQADIPRQQNSSVAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.07|      40|     129|     673|     728|       6
---------------------------------------------------------------------------
  673-  728 (57.72/70.85)	MLEVP.....NKPTQlsyqyylmsvNAADRedspvmALL....LLQFKEN...IQELVYRT..KNGKQPR
  803-  856 (47.35/28.16)	LLKIPpckgvNEETQ..........KALDR......SLLdctfRLQGRNNrtwVAELVFANcpLNGTSTR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20653 with Med14 domain of Kingdom Metazoa
Unable to open file!