<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20652

Description mediator of RNA polymerase II transcription subunit 14 isoform X3
SequenceMLRLPGGAASDRLRERSFSAAPAPLPRPPSSPLPPPPPPLTPVPGAGGLVATWGRASAAGARLPVQRRPGGSKRRRRRRRRRRRRRRLRPRPHRRGDRAPGRETRGPHLVPLRQARFCAAMAPVQLENQLVPPGGGGGGSSGPASAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDHQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYQYYLMSVNAADREDSPVMALLLLQFKENIQELVYRTKNGKQPRSSTKRKLSDDLCPVEPKKTKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHKGVQMEGDGFSHAIRLLKIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPTHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGSSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
Length1483
PositionTail
OrganismTursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Delphinidae> Tursiops.
Aromaticity0.06
Grand average of hydropathy-0.273
Instability index59.50
Isoelectric point9.61
Molecular weight163879.59
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20652
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     286.32|      61|      62|    1082|    1142|       1
---------------------------------------------------------------------------
 1031- 1059 (37.69/ 9.69)	...........................................PPPQQQPFPKQ.PGSSGAYP...........................................L.TSPPTSYHS
 1060- 1127 (99.57/37.95)	TVnqSPSM.MHTQSPG..nlhaassPSGALRAP..SPASFVPTPPPSSHGISIG.PGASFASP...........................................HGTLDPSSPYT
 1128- 1186 (88.34/32.83)	MV..SPSG.RAGNWPGSP...qvsgPSPATRMPgmSPAN......PSLH..SPV.PDASHSPR...........................................AGTSSQTMPTN
 1187- 1289 (60.72/20.21)	MP..PPRKlPQRSWAASI.......PT..ILTH..SALNILLLPSPTP.GLVPGlAGSYLCSPlerflgsvimrrhlqriiqqetlqlinsnepgvimfktdalkcRVALSPKTNQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     212.85|      54|      62|       5|      66|       2
---------------------------------------------------------------------------
    5-   52 (72.86/28.54)	...................PGGAASDRLRERSFSAAPAPLPRPPSSPLPPP.....PPPLTPvpgaGGLVAT
   55-  115 (79.03/31.64)	RASAAGArlPVQ.....rrPGGSKRRRRRRRRRRRRRRLRPRPHRRGDRAPgretrGPHLVP......LRQA
  116-  157 (60.96/16.53)	RFCAAMA..PVQlenqlvpPGGGGGG.......SSGPA......SAP..AP.....PPP.......GAAVA.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.64|      30|      32|     365|     394|       4
---------------------------------------------------------------------------
  365-  394 (48.89/33.95)	RLLKLEILVEDKETGDGRALVH....SMQINFIH
  395-  428 (45.75/31.27)	QLVQSRLFADEKPLQDMYNCLHsfclSLQLEVLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     138.61|      37|      54|     863|     900|       5
---------------------------------------------------------------------------
  863-  893 (43.59/32.43)	..........................HVYLTYENLLsEPVGGRKVVEMFLNDWNSIA
  894-  947 (47.01/30.32)	RLYECVLefarslpdipthlnifsevRVY.NYRKLI.LCYGTTKGSSISI.QWNSIH
  948-  983 (24.96/12.54)	QKFHISL.......gtvgpnsgcsncH.....NTIL......HQLQEMF.NKTPN..
  984- 1002 (23.04/10.99)	.....VV...................QLLQTFLN.............MFV.DSNQDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.76|      15|      17|    1306|    1322|       6
---------------------------------------------------------------------------
 1306- 1322 (21.16/21.70)	ELQVLEKFfeTRVAGPP
 1324- 1338 (24.60/16.26)	KANTLIAF..TKLLGAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     158.51|      41|     100|     163|     203|       8
---------------------------------------------------------------------------
  163-  193 (44.08/21.38)	...............................AASPG..YR....LSTLIEFLLHRAYSEL.MVLT.D...LLP
  194-  259 (33.32/14.49)	RKSDVERKIEivqfasrtrqlfvrllalvkwANNAGkvEK....CAMISSFLDHQAI..L.FVDTaDrlaSLA
  260-  298 (46.50/22.92)	RDALVHARL.........................PS..FA....IPYAIDVLTTGSYPRLpTCIR.D..kIIP
  299-  329 (34.61/15.32)	..PDPITKIE..............................kqatLHQLNQILRHR......LVTT.D...LPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.06|      24|      24|    1392|    1415|       9
---------------------------------------------------------------------------
 1391- 1414 (39.65/21.64)	KMLFFL..QLTQKTSVPPQEPVSIIV
 1415- 1440 (34.41/17.66)	PIIYDMasGTTQQADIPRQQNSSVAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.39|      15|      18|     666|     680|      13
---------------------------------------------------------------------------
  666-  680 (27.47/19.01)	QYYIV.VEMLEVPNKP
  686-  701 (22.92/14.57)	QYYLMsVNAADREDSP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20652 with Med14 domain of Kingdom Metazoa
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