<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20644
Description |
Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MQREEKQLEASLDALLSQVADLKNSLGSFIYKLENEYDRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISKEEREAESGGLRPNKQTFNPADTNALVAAVAFGKGLSNWRPSGSSGPGQPGQPGAGTILAGASGLQQVQMAGAPSQQQPMLSGVQIAQAGQPDIFRERAGRRAIPLSLAVQGQMPQRF |
Length | 273 |
Position | Head |
Organism | Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti>
Delphinidae> Tursiops.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.504 |
Instability index | 42.92 |
Isoelectric point | 6.01 |
Molecular weight | 29811.38 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144
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GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
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GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP20644
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 75.17| 23| 27| 165| 191| 1
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165- 191 (33.84/25.10) GLRPNKQTFNPADTNALVAAvafgKGL
198- 220 (41.33/21.30) GSSGPGQPGQPGAGTILAGA....SGL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 76.18| 25| 28| 67| 92| 2
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67- 92 (40.28/28.65) KTPLFRNQViIP..LVLSPDRD.EDLMRQ
96- 123 (35.90/20.81) RVPVFSHEV.VPdhLRTKPDPEvEEQEKQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 41.07| 15| 35| 12| 26| 3
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12- 26 (25.08/16.72) LD..ALLS.QVADLKNSL
46- 63 (16.00/ 8.34) LDsfALLSgQLNTLNKVL
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