<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20628

Description mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMPPPHEPAWSCCGQRISCPRTPSFKQGFQNAFSVFQDESSSHEYNQRTILLYGVGKEREEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKSKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVIPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACLLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGSNNVSSLKNDDFTVRGLRRDGNADDIWTASQNSKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNNSSNSGMGLFNPNGIGSTDTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEGPTSPISQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNMYRVPPNYSPVSSQMMHHPQSTLWGYNLMGQPQQPGLFLQSQALTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAVMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTPQQQAGSVVLSPTYNSRTYPAAHSNPALMERLRQMQQQPPSGYVQQQASPYLQPLSGSQRLNHQSLQQSPLVGGGLDAVLTSVHPNLPSVSLSQDPVRPRQPQVRQQQRLPQMQQPQQSSQPQGQTLGLQTMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
Length1457
PositionKinase
OrganismTursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Delphinidae> Tursiops.
Aromaticity0.06
Grand average of hydropathy-0.458
Instability index59.96
Isoelectric point8.55
Molecular weight162491.10
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20628
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.71|      19|      19|    1209|    1227|       1
---------------------------------------------------------------------------
 1209- 1227 (37.87/15.76)	QQQQQQRLLRQAQTRPFQQ
 1311- 1328 (29.39/10.45)	QQQPPSGYVQQ.QASPYLQ
 1389- 1406 (24.44/ 7.34)	.QQPQQSSQPQGQTLGLQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     437.80|     151|     189|     597|     784|       2
---------------------------------------------------------------------------
  604-  784 (207.85/222.62)	QAQKLLQLI..CYpHGIKECTEG..DNLQRQhIKRILQNleqWtlRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATievfQQSADL.................NNNssnsgmgLFNP.........NGIGSTDTSSTRQNGiktflsSSERRGVWLvaPLIARLPTSVqGrvlKAAGEELEKGQHLGSSSKKERDRQKQKSM.SLL
  785-  966 (229.95/148.90)	SQQPFLSLVltCL.KGQDEQREGllTSLQNQ.VNQILSN...W..REERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRST....QWTTDWallllqiitsgtvdmhtNNE.......LFTTvldmlgvliNGTLASDLSNASPGG......SEENKRAYM..NLVKKLKKEL.G...DKRSESIDKVRQLLPLPKQTCDVITCEPMgSLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     188.79|      42|      44|     203|     244|       3
---------------------------------------------------------------------------
  185-  210 (23.46/ 9.07)	....LLLKSSSLAGSYtTGL...C................vC...............IVAVLRR
  211-  255 (71.12/43.11)	YHSCLILNPDQTAQVF.EGL...CGVVKHVVNPSECSSperC...............ILAYLYD
  257-  282 (30.76/14.29)	YVSCSHLRS.KFGDLF.SSA...CSKVKQTI.................................
  416-  459 (20.37/ 6.87)	.............QCF..SL...EDVVQHVALPSLLAA..aCgdadaepgarmtcrlLLHLFRA
  460-  501 (43.08/23.09)	PQACLL..PQATGKPF.PGIrssCD..RHLLAAAHNSIevgA...............VFAVL..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     217.12|      36|      79|    1153|    1188|       4
---------------------------------------------------------------------------
 1097- 1154 (25.70/ 8.50)	TKSSSRVDeyPQSNMyrV.....PPNYSPVSSQ...M........M....................hhpqstlwgynlmgqpqqpglflqsqAL
 1155- 1236 (36.38/15.50)	TPGGSRLD..PAGSF..V.....PTNTKQALSN...MLQRRSGAVMqppslhaitsqqqliqmkllqqqqqqrllrqaqtrpfqqgqpgdqaAL
 1237- 1265 (37.82/16.44)	FAAQARPS..PQL...........PQY.PGLQQaqtMPQ...GYTM................................................
 1267- 1285 (25.52/ 8.38)	............GTQ..M.....P......LQQ...TPQQQAGSVV...............................................L
 1332- 1355 (29.82/11.20)	..GSQRLN..HQS.................LQQ...SPLVGGGLDA..............................................VL
 1356- 1383 (26.80/ 9.22)	T...S.VH..PNLPS..VslsqdPVRPRQ..PQ...VRQQQ.....................................................
 1409- 1431 (35.07/14.64)	..........PQQPL..F.....P...RQGLQQ...TQQQQQTA................................................AL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.39|      23|      28|    1036|    1058|       5
---------------------------------------------------------------------------
 1036- 1058 (45.19/21.98)	THPM...PKPRSYYLEPLPLPPEEEE
 1062- 1087 (31.20/13.11)	TSPIsqePERKSAELSDQGKTTTDEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.81|      35|     182|     321|     362|       7
---------------------------------------------------------------------------
  321-  356 (56.44/60.18)	LSDNAANRYSFVCNTLMNVcMGHQDAGRINDIANFS
  366-  400 (62.37/42.52)	LSSEWLGVLKALCCSSNHV.WGFNDVLCTVDVSDLS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20628 with Med12 domain of Kingdom Metazoa
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