<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20615

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAVMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYASPSDLLDDKTTSPIILHENNVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYVPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCSGSNKAKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQSSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDPDVFQANNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFTSQALNTLGVPMLGGDNGETKFKGNSQADTVDFSIIAVAGKALGPTDLMEHHSGSQSPLLTTGDLGKEKTQKRVKEGNGTSSSSLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSCSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSASNSGKMKSSKSEGSSSSKLSSSIYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSTGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQVGVSTNSSSHPVSSKHNMSGGEFQGKREKSDKDKSKVSTLGGSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSTDRPSRLSPDFMIGEEDDDLMDVALIGN
Length1579
PositionMiddle
OrganismTursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Delphinidae> Tursiops.
Aromaticity0.04
Grand average of hydropathy-0.675
Instability index53.75
Isoelectric point8.87
Molecular weight168259.03
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20615
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     536.90|      64|      64|    1216|    1279|       1
---------------------------------------------------------------------------
  993- 1053 (64.98/16.05)	GKRSRTPS...NDGKS...........kdkppkrkkaDT.......EG.KSP.SHSCS.........NR........P.FTPPT.STGG.SKS...P...GS.........SGR.....SQ.TPP
 1078- 1119 (51.07/10.83)	SSHSQYTS...SGSVSSSGSK...................................SH.........HS........H.SSSSSaSNSGkMKS...S........................KSEG
 1120- 1197 (71.61/18.55)	SSSS.KLS...SSIYSSQGSS.....G..........SS.......QS.KN..SSQSG.........GKpgsspitkHgLSSGS.SSTK.MKP...QGKPSSlmnpslskpNIS....PSHSRPP
 1198- 1259 (102.79/30.27)	GGSDKLAS...PMK.PVPGTP.....P..........SS.......KA.KSPISSGSG.........GS........H.MSGTS.SSTG.MKS...SSGLGS.........SGS....LSQKTPP
 1260- 1329 (75.58/20.04)	SSNSCTAS...SSSFSSSGSS....MS..........SSqnqhgssKG.KSP....SR.........NK........K.PSLTA.VIDK.LKHgvvTSGPGG.........EDP....MDGQVGV
 1330- 1397 (57.51/13.25)	STN....S...SSHPVSSKHN....MSggefqgkrekSD.......KD.KSKVST.LG.........GS.............VD.SSKK.TSE...SKNVGS.........TGVakiiIS.KHDG
 1398- 1457 (60.49/14.37)	GSPSIKAKvtlQKPGESSGEGlrpqMA..........SS.......KNyGSPLISGST.........PK........H.ERG..........S...PSHSKS.........PAY........TPQ
 1458- 1523 (52.88/11.51)	NLDSE..........SESGSS....IA.........eKS.......YQ.NSP.SSDDGirplpeystEK........H.KKHKK.EKKK.VKD...KDRDRD.........RDK....DRDKKKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     146.19|      41|      50|     324|     373|       2
---------------------------------------------------------------------------
  272-  321 (49.01/18.60)	......PLiMGSHPVdnkWTPSFSSITSansvdlpacFFL.KFPQPIPVSRA....FVQKL
  322-  367 (69.04/34.62)	QnctgiPL.FETQPT...YVPLYELITQ.........FELSKDPDPIPLNHNMR..FYAAL
  371-  396 (28.14/18.94)	Q..................................hcYFLNKDA.PLPDGRSLQgtLVSKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     280.49|      50|      50|     614|     663|       3
---------------------------------------------------------------------------
  549-  598 (42.20/13.41)	.GMTTGNNP....M..SGTTTPT...................................NT......FPGGpiTTL...FNMSMS.IK....DrhesvGHGEDFSKV...
  614-  663 (94.29/39.29)	GGSTIGSSP....TPPHHTPPPV...................................SS......MAGN..TKN...HPMLMNLLK....D.....NPAQDFSTLYGS
  734-  796 (51.74/18.14)	DTPHITPAPsqcsTPPTTYPQPV...............................phpqSSiqrmvrLSSS..DSI...GPDVTDILS....D......IAEEASKLPST
  797-  844 (45.85/15.22)	......SDD....CPPIGTPVRD...................................SS......SSGH..SQSalfDP...DVFQannnE.....NPYTDPADLIAD
  846-  923 (46.40/15.49)	AGSPSSDSP....T.NHFFPDGVdfnpdllnsqsqsgfgeeyfdessqsgdnddfkgfTS......QALN..TLG...VPMLGG.......D.....NGETKFK...GN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.12|      44|     340|     101|     150|       4
---------------------------------------------------------------------------
  101-  150 (67.78/54.25)	CYITSDMFYVEVQlDPAGQ..LC...DVKVAHHgenpVSCpELVQQLREK..NFDEF
  443-  493 (68.34/37.16)	CPLSESRFSVSFQ.HPVNDslVCvvmDVQDSTH....VSC.KLYKGLSDAliCTDDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.86|      42|      64|     153|     197|       5
---------------------------------------------------------------------------
  165-  213 (60.54/41.28)	GDNKLKTKMYLALQSLEQDLSKMAVMYWKatNA......gpldkILHGSVG.YLTP
  216-  269 (58.32/38.62)	GGHLMNLKYYASPSDLLDDKTTSPIILHE..NNvprslgmnasvTIEGTSAmYKLP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20615 with Med1 domain of Kingdom Metazoa
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