<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20614

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAVMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYASPSDLLDDKTTSPIILHENNVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYVPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCSGSNKAKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQSSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDPDVFQANNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFTSQALNTLGVPMLGGDNGETKFKGNSQADTVDFSIIAVAGKALGPTDLMEHHSGSQSPLLTTGDLGKEKTQKRVKEGNGTSSSSLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSCSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSASNSGKMKSSKSEGSSSSKLSSSIYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSTGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQVGVSTNSSSHPVSSKHNMSGGEFQGKREKSDKDKSKVSTLGGSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSTDRPSRLSPDFMIGEEDDDLMDVALIGN
Length1564
PositionMiddle
OrganismTursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Delphinidae> Tursiops.
Aromaticity0.04
Grand average of hydropathy-0.666
Instability index53.48
Isoelectric point8.90
Molecular weight166582.19
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP20614
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     536.90|      64|      64|    1201|    1264|       1
---------------------------------------------------------------------------
  978- 1038 (64.98/12.95)	GKRSRTPS...NDGKS...........kdkppkrkkaDT.......EG.KSP.SHSCS.........NR........P.FTPPT.STGG.SKS...P...GS.........SGR.....SQ.TPP
 1063- 1104 (51.07/ 8.71)	SSHSQYTS...SGSVSSSGSK...................................SH.........HS........H.SSSSSaSNSGkMKS...S........................KSEG
 1105- 1182 (71.61/14.97)	SSSS.KLS...SSIYSSQGSS.....G..........SS.......QS.KN..SSQSG.........GKpgsspitkHgLSSGS.SSTK.MKP...QGKPSSlmnpslskpNIS....PSHSRPP
 1183- 1244 (102.79/24.46)	GGSDKLAS...PMK.PVPGTP.....P..........SS.......KA.KSPISSGSG.........GS........H.MSGTS.SSTG.MKS...SSGLGS.........SGS....LSQKTPP
 1245- 1314 (75.58/16.18)	SSNSCTAS...SSSFSSSGSS....MS..........SSqnqhgssKG.KSP....SR.........NK........K.PSLTA.VIDK.LKHgvvTSGPGG.........EDP....MDGQVGV
 1315- 1382 (57.51/10.67)	STN....S...SSHPVSSKHN....MSggefqgkrekSD.......KD.KSKVST.LG.........GS.............VD.SSKK.TSE...SKNVGS.........TGVakiiIS.KHDG
 1383- 1442 (60.49/11.58)	GSPSIKAKvtlQKPGESSGEGlrpqMA..........SS.......KNyGSPLISGST.........PK........H.ERG..........S...PSHSKS.........PAY........TPQ
 1443- 1508 (52.88/ 9.26)	NLDSE..........SESGSS....IA.........eKS.......YQ.NSP.SSDDGirplpeystEK........H.KKHKK.EKKK.VKD...KDRDRD.........RDK....DRDKKKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     178.03|      48|      50|     309|     358|       2
---------------------------------------------------------------------------
  257-  306 (46.21/20.51)	.........PLiMGSHPVdnkWTPSFSSITSansvdlpacFFL.KFPQPIPVSRA....FVQKL
  307-  352 (73.56/38.22)	...QnCTGIPL.FETQPT...YVPLYELITQ.........FELSKDPDPIPLNHNMR..FYAAL
  353-  381 (35.54/20.89)	PGQQ..................................hcYFLNKDA.PLPDGRSLQgtLVSKI
  727-  744 (22.71/ 6.23)	PSQ..CSTPPT.TYPQPV...PHP........................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     262.44|      57|      64|     532|     588|       3
---------------------------------------------------------------------------
  532-  585 (97.48/44.43)	.............GYGMTTGNNPMSGTTT...PTN.TFPGGPI......TTL..FNMSMS.IKDRHESVGHGEDFS.KV.SQ
  586-  648 (60.06/24.33)	NPIltsllqitgnG.GSTIGSSP....TP...PHH.TPP..PVssmagnTKN..HPMLMNlLKD.....NPAQDFS.TLyGS
  649-  705 (51.30/19.62)	SPLerqnsssgspRMEMCSGSNKAKKKKSsrlP.....PDKP....................KHQTEDDFQRELFSmDVdSQ
  832-  873 (53.60/20.86)	...................GS.PSS..DS...PTNhFFPDG...........vdFNPDL..LNSQSQSGFGEEYFD.ES.SQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.79|      38|      50|     131|     168|       4
---------------------------------------------------------------------------
  131-  149 (21.42/ 7.41)	..................................NFD.EFSKHLKGLVNLYNLP
  150-  198 (53.46/29.73)	GDNKLKTKMYLALQSLEQD...lskmavmywkatNAG.PLDKILHGSVG.YLTP
  201-  254 (48.91/26.56)	GGHLMNLKYYASPSDLLDDkttspiilhennvprSLGmNASVTIEGTSAMYKLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.51|      12|      22|     875|     887|       5
---------------------------------------------------------------------------
  875-  887 (20.41/14.40)	GDNDD..FKGfTSQA
  898-  911 (20.10/ 8.91)	GDNGEtkFKG.NSQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.33|      18|      22|     755|     776|       6
---------------------------------------------------------------------------
  755-  776 (25.51/17.60)	SSSDS...IGPDVtdilSDIAEEAS
  780-  800 (24.83/ 8.97)	STSDDcppIGTPV....RDSSSSGH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.10|      15|      96|     708|     726|       7
---------------------------------------------------------------------------
  708-  726 (23.48/21.84)	IFDVNMTadtlDTPHITPA
  810-  824 (27.62/15.15)	VFQANNN....ENPYTDPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.57|      18|      22|     432|     449|       8
---------------------------------------------------------------------------
  432-  449 (32.33/19.68)	ES.RFSVSFQHPVNDSLVC
  456-  474 (24.24/12.74)	DStHVSCKLYKGLSDALIC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20614 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AGKALGPTDLMEHHSGSQSPLLTTGDLGKEKTQKRVKEGNGTSSSSLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSCSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSASNSGKMKSSKSEGSSSSKLSSSIYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSTGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQVGVSTNSSSHPVSSKHNMSGGEFQGKREKSDKDKSKVSTLGGSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSTDRPSRLSPDFMIGEEDDDLMDVALIGN
2) KNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGP
3) LFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCSGSNKAKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQSSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDPDVFQANNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFN
4) LLNSQSQSGFGEEYFDESSQSGDNDDFKGFTSQALNTLGVPMLGGDNGETKFKGNSQAD
922
523
560
854
1564
556
851
912










Molecular Recognition Features






MoRF SequenceStartStop




1) FGEEYFD
2) IRPLPEYSTEKHKKHKKEKKKVKDKDRD
3) KITIQIPK
4) KPSLTAVIDKLKHGV
5) RLSPDFMIGEEDDDLMDV
6) SIKAKVTLQK
7) VAKIIISKH
863
1469
1047
1283
1542
1386
1372
869
1496
1054
1297
1559
1395
1380