<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20614

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAVMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYASPSDLLDDKTTSPIILHENNVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYVPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCSGSNKAKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQSSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDPDVFQANNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFTSQALNTLGVPMLGGDNGETKFKGNSQADTVDFSIIAVAGKALGPTDLMEHHSGSQSPLLTTGDLGKEKTQKRVKEGNGTSSSSLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSCSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSASNSGKMKSSKSEGSSSSKLSSSIYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSTGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQVGVSTNSSSHPVSSKHNMSGGEFQGKREKSDKDKSKVSTLGGSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSTDRPSRLSPDFMIGEEDDDLMDVALIGN
Length1564
PositionMiddle
OrganismTursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Whippomorpha> Cetacea> Odontoceti> Delphinidae> Tursiops.
Aromaticity0.04
Grand average of hydropathy-0.666
Instability index53.48
Isoelectric point8.90
Molecular weight166582.19
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20614
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     536.90|      64|      64|    1201|    1264|       1
---------------------------------------------------------------------------
  978- 1038 (64.98/12.95)	GKRSRTPS...NDGKS...........kdkppkrkkaDT.......EG.KSP.SHSCS.........NR........P.FTPPT.STGG.SKS...P...GS.........SGR.....SQ.TPP
 1063- 1104 (51.07/ 8.71)	SSHSQYTS...SGSVSSSGSK...................................SH.........HS........H.SSSSSaSNSGkMKS...S........................KSEG
 1105- 1182 (71.61/14.97)	SSSS.KLS...SSIYSSQGSS.....G..........SS.......QS.KN..SSQSG.........GKpgsspitkHgLSSGS.SSTK.MKP...QGKPSSlmnpslskpNIS....PSHSRPP
 1183- 1244 (102.79/24.46)	GGSDKLAS...PMK.PVPGTP.....P..........SS.......KA.KSPISSGSG.........GS........H.MSGTS.SSTG.MKS...SSGLGS.........SGS....LSQKTPP
 1245- 1314 (75.58/16.18)	SSNSCTAS...SSSFSSSGSS....MS..........SSqnqhgssKG.KSP....SR.........NK........K.PSLTA.VIDK.LKHgvvTSGPGG.........EDP....MDGQVGV
 1315- 1382 (57.51/10.67)	STN....S...SSHPVSSKHN....MSggefqgkrekSD.......KD.KSKVST.LG.........GS.............VD.SSKK.TSE...SKNVGS.........TGVakiiIS.KHDG
 1383- 1442 (60.49/11.58)	GSPSIKAKvtlQKPGESSGEGlrpqMA..........SS.......KNyGSPLISGST.........PK........H.ERG..........S...PSHSKS.........PAY........TPQ
 1443- 1508 (52.88/ 9.26)	NLDSE..........SESGSS....IA.........eKS.......YQ.NSP.SSDDGirplpeystEK........H.KKHKK.EKKK.VKD...KDRDRD.........RDK....DRDKKKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     178.03|      48|      50|     309|     358|       2
---------------------------------------------------------------------------
  257-  306 (46.21/20.51)	.........PLiMGSHPVdnkWTPSFSSITSansvdlpacFFL.KFPQPIPVSRA....FVQKL
  307-  352 (73.56/38.22)	...QnCTGIPL.FETQPT...YVPLYELITQ.........FELSKDPDPIPLNHNMR..FYAAL
  353-  381 (35.54/20.89)	PGQQ..................................hcYFLNKDA.PLPDGRSLQgtLVSKI
  727-  744 (22.71/ 6.23)	PSQ..CSTPPT.TYPQPV...PHP........................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     262.44|      57|      64|     532|     588|       3
---------------------------------------------------------------------------
  532-  585 (97.48/44.43)	.............GYGMTTGNNPMSGTTT...PTN.TFPGGPI......TTL..FNMSMS.IKDRHESVGHGEDFS.KV.SQ
  586-  648 (60.06/24.33)	NPIltsllqitgnG.GSTIGSSP....TP...PHH.TPP..PVssmagnTKN..HPMLMNlLKD.....NPAQDFS.TLyGS
  649-  705 (51.30/19.62)	SPLerqnsssgspRMEMCSGSNKAKKKKSsrlP.....PDKP....................KHQTEDDFQRELFSmDVdSQ
  832-  873 (53.60/20.86)	...................GS.PSS..DS...PTNhFFPDG...........vdFNPDL..LNSQSQSGFGEEYFD.ES.SQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.79|      38|      50|     131|     168|       4
---------------------------------------------------------------------------
  131-  149 (21.42/ 7.41)	..................................NFD.EFSKHLKGLVNLYNLP
  150-  198 (53.46/29.73)	GDNKLKTKMYLALQSLEQD...lskmavmywkatNAG.PLDKILHGSVG.YLTP
  201-  254 (48.91/26.56)	GGHLMNLKYYASPSDLLDDkttspiilhennvprSLGmNASVTIEGTSAMYKLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.51|      12|      22|     875|     887|       5
---------------------------------------------------------------------------
  875-  887 (20.41/14.40)	GDNDD..FKGfTSQA
  898-  911 (20.10/ 8.91)	GDNGEtkFKG.NSQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.33|      18|      22|     755|     776|       6
---------------------------------------------------------------------------
  755-  776 (25.51/17.60)	SSSDS...IGPDVtdilSDIAEEAS
  780-  800 (24.83/ 8.97)	STSDDcppIGTPV....RDSSSSGH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.10|      15|      96|     708|     726|       7
---------------------------------------------------------------------------
  708-  726 (23.48/21.84)	IFDVNMTadtlDTPHITPA
  810-  824 (27.62/15.15)	VFQANNN....ENPYTDPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.57|      18|      22|     432|     449|       8
---------------------------------------------------------------------------
  432-  449 (32.33/19.68)	ES.RFSVSFQHPVNDSLVC
  456-  474 (24.24/12.74)	DStHVSCKLYKGLSDALIC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20614 with Med1 domain of Kingdom Metazoa
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