<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20596

Description LOW QUALITY PROTEIN: mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQATDPNLEWTQISTRYLREQLAKISDFYHVASSAGDGPVPVPPDVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLALLLSDSPSLLAVHSPHMMIGPNSSSIGAPSPGAPGPVMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNDNKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEAEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAIAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSMPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPAGENVDEHYPKDHDMKMEEQTIMAHMGIDSGTTNIFDEVDKNDFKTDFGSEFPIFSPMPGESCENANPSLGRRMSVNGEKLLKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGPKARKNKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACLLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNNVSSLKNDDFTMRGLRRDGNADDIWTASQNSKSCGKNISIETANLKEYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNNSSNSGMGFFNPNGIANTDTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDMKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTATDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMLHHPQSTLWGYNLLGQPQQPGFFLQNQSLTPGGSRLDPTGSYVPTNTKQALSNMLQRRSGAMMQPPPLHAITSQQQLIQMKLLQQQQQQRLLRQAQARPFQQDFCNSAVSLLEDFDNIMGPPGDQAALFAAHARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTPQQQAGGVVLSPSYNSRTYPAAHSSPALMERLRQMQQPPSGYVQQQASPYLQSLTGSQRLNHQSLQQSPLVGGGIDAVLTSTHPSLPSVPLPQDPMRPRQPQVRQQQRLLQVLSNPFSFQMQQPPQPQSQTLGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSKYPALQNRWLPGDSRQESRTHVLAPQTVPCLPSVPFTSSFESRLVCDANSPSHHTSSRSRQCALMKRIPPVLLDVTGDIFRNANQPPVMQRILAWELGSLNPGASPTIIFWTMYFFVHAARRLVGPAVSPGSLVVCFGGME
Length2318
PositionKinase
OrganismOdobenus rosmarus divergens (Pacific walrus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Odobenidae> Odobenus.
Aromaticity0.07
Grand average of hydropathy-0.383
Instability index58.27
Isoelectric point7.49
Molecular weight259053.60
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20596
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     183.22|      25|      25|    1872|    1896|       1
---------------------------------------------------------------------------
 1872- 1896 (35.61/15.62)	GSRLDPTG.SYVPTNTKQALS.NMLQR
 1899- 1924 (33.58/14.24)	GAMMQPPP.LHAITSQQQLIQmKLLQQ
 1993- 2018 (35.47/15.52)	GYTMYGTQmPLQQTPQQQAGG.VVLSP
 2099- 2120 (30.14/11.90)	QDPMRPRQ.P..QVRQQQRLL.QVLS.
 2127- 2145 (25.26/ 8.59)	..MQQPPQ......PQSQTLGlQAMQP
 2146- 2162 (23.16/ 7.17)	QQPLFPRQ.GLQQTQQQQ.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     183.25|      57|     286|    1359|    1416|       2
---------------------------------------------------------------------------
 1359- 1416 (92.56/66.77)	RQSWLELQLMIKQCLKDPGSGSVAEMNNLLDnIAKATIEVF..QQSADLNNNSSNSGMGF
 1632- 1690 (90.69/60.53)	KRAYMNLVKKLKKELGDKRSESIDKVRQLLP.LPKQTCDVItcEPMGSLIDTKGNKIAGF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.22|      16|      27|    1146|    1171|       3
---------------------------------------------------------------------------
 1150- 1165 (32.18/25.29)	ACGDADAE....PGARMTCR
 1176- 1195 (26.04/16.76)	ACLLPQATgkpfPGIRSSCD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.17|      16|      27|     899|     915|       4
---------------------------------------------------------------------------
  899-  915 (22.97/20.10)	LLLKSSSLAGSYtTGLC
  929-  944 (29.21/20.25)	LILNPDQTAQVF.EGLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.10|      23|     196|    1056|    1107|       5
---------------------------------------------------------------------------
 1054- 1076 (42.37/41.75)	CMGHQDAGRIND.IANFSSELTA..C
 1106- 1131 (30.74/38.05)	CTVDVSDLSFHDsLATFIAILIArqC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.60|      19|     286|     386|     411|       6
---------------------------------------------------------------------------
  386-  411 (27.41/26.67)	NDNKSaNPGSPLDLLQvapsslPMPG
  680-  698 (39.19/19.18)	NDFKT.DFGSEFPIFS......PMPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.90|      23|     153|    2022|    2059|       8
---------------------------------------------------------------------------
 1944- 1966 (36.92/ 8.76)	CNSAVSLLEDFDNIMGPPG....DQAA
 2028- 2054 (35.97/41.09)	AHSSPALMERLRQMQQPPSgyvqQQAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.08|      19|     196|      21|      45|      12
---------------------------------------------------------------------------
   21-   45 (27.66/28.78)	PPDVyPQDPKQKEdeltaVNVKQGF
  220-  238 (38.43/20.96)	PPDV.EQAMKQWE.....YNEKLAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.78|      13|     126|    1856|    1870|      17
---------------------------------------------------------------------------
 1856- 1870 (21.43/17.39)	PQQPGffLQNQSLTP
 1979- 1991 (27.34/14.38)	PQYPG..LQQAQTMP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.87|      33|     126|    2055|    2091|      18
---------------------------------------------------------------------------
 1541- 1574 (56.09/29.98)	YQDDMKARQ.MMHEALQlRLNLVGGMFDTVQRSTQ
 2056- 2089 (53.77/36.73)	YLQSLTGSQrLNHQSLQ.QSPLVGGGIDAVLTSTH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.89|      15|      23|    2180|    2196|      19
---------------------------------------------------------------------------
 2180- 2196 (23.16/22.51)	PALQNrwLPGDSRQESR
 2206- 2220 (29.73/18.85)	PCLPS..VPFTSSFESR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.23|      18|     201|     745|     766|      20
---------------------------------------------------------------------------
  745-  766 (29.71/27.08)	HFPIPLDESSSHECnqrtILLY
  949-  966 (35.52/21.15)	HVVNPSECSSPERC....ILAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.73|      22|     181|    1314|    1338|      24
---------------------------------------------------------------------------
 1314- 1336 (35.32/17.40)	LSNMQAQKLLQLI..CYpHGIKECT
 1495- 1518 (32.41/15.58)	MSLLSQQPFLSLVltCL.KGQDEQR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20596 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PGFFLQNQSLTPGGSRLDPTGSYVPTNTKQALSNMLQRRSGAMMQPPPLHAI
2) PPGDQAALFAAHARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTPQQQAGGVVLSPSYNSR
3) RSYYLEPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTATDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMLH
4) SNPFSFQMQQPPQPQSQTLGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQ
5) TASTRPRSPAGENVDEHYPKDHDMKMEEQTIMA
6) YPAAHSSPALMERLRQMQQPPSGYVQQQASPYLQSLTGSQRLNHQSLQQSPLVGGGIDAVLTSTHPSLPSVPLPQDPMRPRQPQVRQQQR
1859
1960
1757
2120
630
2025
1910
2023
1841
2170
662
2114










Molecular Recognition Features






MoRF SequenceStartStop




1) MAAFGLLSYEQRPLKRPRLGPPDVY
2) YYLEPLPLP
1
1759
25
1767