<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20595

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPSRGPGQSLGGMGGLGTMGQPMPLSGQPPPGTSGMAPHGMAVVSTAAPQTQLQLQQVALQQQQQQFQQQQVALQQQQQQQQQQQQQQQFQAQQNAMQQQFQAVVQQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQLQRMAQLQLQQQQQQQALQAQPPLQQPPMQQPQPPPSQALPQQLQPMHHPQHHQPPPPPQQPPVAQNQPPQLPPQSQTQPLVSQAPALPGQMLYAQPQLKLVRTPMVVQQPQVQPQVQQVQPQVQQQTAVPTAQASQIVGSGVQVSQNSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVMCTRKRKFEDDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPANYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA
Length720
PositionTail
OrganismOdobenus rosmarus divergens (Pacific walrus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Odobenidae> Odobenus.
Aromaticity0.03
Grand average of hydropathy-0.714
Instability index87.92
Isoelectric point9.54
Molecular weight79260.28
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20595
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.18|      28|      32|     228|     259|       2
---------------------------------------------------------------------------
  209-  247 (47.73/11.24)	QQ...QQLQRMaqlqlqqqqqqQALQAQPPLQQPPMQQPQPP
  249-  282 (41.45/ 9.77)	SQalpQQLQPM........hhpQHHQPPPPPQQPPVAQNQPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     215.01|      42|      43|     286|     327|       4
---------------------------------------------------------------------------
  105-  142 (45.37/ 8.02)	PGT...........SGMAPhgmaVVSTA.A..P..................QTQLQLQ..QVALQ...QQQQQFQ
  285-  326 (76.64/19.55)	PPQ...........SQTQP....LVSQAPAL.P....GQML.....YA...QPQLKLV..RTPMV...VQQPQVQ
  327-  380 (48.00/ 9.00)	PQV...........QQVQP....QVQQQTAV.PtaqaSQIVgsgvqVS...QNSLTML..SSPSPgqqVQTPQSM
  381-  439 (45.01/ 7.89)	PPPpqpspqpgqpsSQPNS....NVSSGPAPsP....SSFL.....PSpspQPSQSPVtaRTPQN...FSVPSPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.91|      26|      27|     495|     521|       5
---------------------------------------------------------------------------
  486-  517 (34.48/15.24)	DKNEdrkkdLSKMKSLLDILTDPSKRCPlKTL
  518-  545 (44.43/17.27)	QKCE...iaLEKLKNDMAVPTPPPPPVP.PTK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.34|      17|      17|      65|      81|       7
---------------------------------------------------------------------------
   65-   81 (32.35/18.41)	GPAAGAAGIGMPSRGPG
   85-  101 (32.98/18.93)	GGMGGLGTMGQPMPLSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.08|      18|      22|     614|     631|       9
---------------------------------------------------------------------------
  614-  631 (32.84/15.50)	VARLDPKFLVNLDPSHCS
  639-  656 (32.24/15.11)	ICKLDDKDLPSVPPLELS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.79|      11|      27|     678|     688|      10
---------------------------------------------------------------------------
  678-  688 (23.12/12.30)	NPFLQSVHR.CM
  706-  717 (18.67/ 8.69)	NTWAQSIHQaCL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20595 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPSRGPGQSLGGMGGLGTMGQPMPLSGQPPPGTSGMAPHGMAVVSTAA
2) QQQQQQALQAQPPLQQPPMQQPQPPPSQALPQQLQPMHHPQHHQPPPPPQQPPVAQNQPPQLPPQSQTQPLVSQAPALPGQMLYAQPQLKLVRTPMVVQQPQVQPQVQQVQPQVQQQTAVPTAQASQIVGSGVQVSQNSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
44
223
122
470










Molecular Recognition Features






MoRF SequenceStartStop




NANANA