<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20594

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPSRGPGQSLGGMGGLGTMGQPMPLSGQPPPGTSGMAPHGMAVVSTAAPQTQLQLQQVALQQQQQQFQQQQVALQQQQQQQQQQQQQQQFQAQQNAMQQQFQAVVQQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQLQRMAQLQLQQQQQQQALQAQPPLQQPPMQQPQPPPSQALPQQLQPMHHPQHHQPPPPPQQPPVAQNQPPQLPPQSQTQPLVSQAPALPGQMLYAQPQLKLVRTPMVVQQPQVQPQVQQVQPQVQQQTAVPTAQASQIVGSGVQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVMCTRKRKFEDDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPANYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA
Length729
PositionTail
OrganismOdobenus rosmarus divergens (Pacific walrus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Odobenidae> Odobenus.
Aromaticity0.03
Grand average of hydropathy-0.719
Instability index86.95
Isoelectric point9.42
Molecular weight80467.57
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20594
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     144.52|      31|      32|     393|     424|       3
---------------------------------------------------------------------------
  197-  234 (36.55/ 6.70)	MQQQfQAV.VQQQQQQLQQQQQQQQHLiklhhqNQQQIQ
  296-  326 (53.45/10.30)	PPQQ.PPV.AQNQPPQLPPQSQTQPLV......SQAPAL
  385-  416 (54.53/10.68)	TPQS.MPPpPQPSPQPGQPSSQPNSNV......SSGPAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.87|      16|      86|     150|     166|       4
---------------------------------------------------------------------------
  150-  166 (26.52/ 8.89)	QTQLQLQQVaLQQQQQQ
  350-  365 (30.35/ 7.67)	QVQPQVQQV.QPQVQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.26|      19|      21|      95|     115|       5
---------------------------------------------------------------------------
   95-  113 (38.28/18.97)	GAAGIGMPSRG.PGQSLGGM
  117-  136 (34.98/11.55)	GTMGQPMPLSGqPPPGTSGM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.08|      18|      22|     623|     640|       7
---------------------------------------------------------------------------
  623-  640 (32.84/19.44)	VARLDPKFLVNLDPSHCS
  648-  665 (32.24/18.95)	ICKLDDKDLPSVPPLELS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      77.17|      17|      95|     440|     456|       8
---------------------------------------------------------------------------
  439-  455 (31.79/14.87)	PQNFSVPSPGPLNTPVN
  538-  551 (23.17/ 8.51)	.NDMAVPTPPP..PPVP
  585-  599 (22.20/ 7.80)	PAMTAIHGP.PITAPV.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.83|      12|      41|     238|     249|       9
---------------------------------------------------------------------------
  238-  249 (21.43/ 7.65)	QLQRMAQLQLQQ
  281-  292 (26.40/11.28)	QLQPMHHPQHHQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.79|      11|      27|     687|     697|      10
---------------------------------------------------------------------------
  687-  697 (23.12/15.87)	NPFLQSVHR.CM
  715-  726 (18.67/11.26)	NTWAQSIHQaCL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20594 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPSRGPGQSLGGMGGLGTMGQPMPLSGQPPPGTSGMAPHGMAVVSTAA
2) QQQQQQALQAQPPLQQPPMQQPQPPPSQALPQQLQPMHHPQHHQPPPPPQQPPVAQNQPPQLPPQSQTQPLVSQAPALPGQMLYAQPQLKLVRTPMVVQQPQVQPQVQQVQPQVQQQTAVPTAQASQIVGSGVQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
70
249
148
479










Molecular Recognition Features






MoRF SequenceStartStop




NANANA