<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20592

Description mediator of RNA polymerase II transcription subunit 12 isoform X2
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVIDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVMSAQSTSTLPATPAPQPPTSSAPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDSERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPYRLLDSEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDNQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGERQSDSLEKVLQLLPLPKPTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHTNPGSISHLSYRQGSIGLYTQNQPLPAGGPRMDSYRPVRLPMQKLPTRPPYPGVLPTTMTGVMGLEPSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLASTQRFSQQTLQQAPMIGAMTPLGAQGVQAGGVRSASILPEQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQQQQILRQQQQQQQQQQQQQQQQQAHQQQQQQQQAAPPQAQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2175
PositionKinase
OrganismOdobenus rosmarus divergens (Pacific walrus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Odobenidae> Odobenus.
Aromaticity0.07
Grand average of hydropathy-0.486
Instability index57.10
Isoelectric point6.75
Molecular weight242413.29
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20592
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     176.33|      15|      15|    2054|    2068|       1
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 2054- 2068 (35.21/13.11)	QQQQQQ..QQQ...QQQQQQ
 2070- 2087 (28.44/ 9.28)	QQQQQQ..QQQyhiRQQQQQ
 2088- 2102 (29.80/10.05)	QQQQIL..RQQ...QQQQQQ
 2103- 2117 (33.58/12.19)	QQQQQQ..QQQ...AHQQQQ
 2118- 2132 (26.13/ 7.97)	QQQQAA..PPQ...AQPQSQ
 2133- 2149 (23.18/ 6.31)	PQFQRQglQQT...QQQQQT
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.20|      25|      46|     346|     370|       2
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  346-  370 (47.16/25.36)	PFSDLLMCPQHRPLVFGLSCILQTI
  394-  418 (46.04/24.57)	PLDHLPIAPSNLPMPEGNSAFTQQV
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     113.91|      18|      18|    1734|    1751|       3
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  683-  699 (26.05/10.57)	PDFSLFSP....TMPCEGKGS
 1734- 1751 (33.32/15.97)	PRAYYLEP...LPLPPEDEEP
 1752- 1772 (26.94/11.23)	PAPTLLEPekkAPEPPKTDKP
 1795- 1811 (27.59/11.72)	P.ATKTED...YGMGPGRSGP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     276.45|      52|      56|    1815|    1868|       4
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 1815- 1859 (78.35/40.74)	...............TVP..PDL.......LH.HTNPGSIS...HLSYRQG......SIGLYTQNQPLPAGGPRMDSYR
 1862- 1911 (63.73/34.78)	RLPMQKL.......pTRPpyPGV.......LP.TTMTGVMG..lEPSYK.T......SV..YRQQQPAVPQGQRL...R
 1912- 1963 (34.98/13.07)	....QQLqakiqsqgMLG..QSS.......VH.QMTPSSSY...GLQTSQGytpyvsHVGL..QQHTGPAG........
 1966- 2016 (45.75/19.94)	................VP..PSYssqpyqsTHpSTNPTLVDptrHLQQRPS........G.YVHQQA.PTYGHGLASTQ
 2017- 2051 (53.65/22.43)	RFSQQTL........QQA..PMI..............GAMT...PLG.................AQGVQAGGVRSASIL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.16|      16|      20|    1047|    1063|       5
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 1047- 1062 (29.43/11.47)	NP..ANRYSFVCNALMHV
 1068- 1085 (20.73/ 6.92)	DPdrVNDIAILCAELTGY
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     319.48|     110|     233|     217|     336|       6
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  217-  287 (106.67/55.40)	....................................................................................................................................................................GSTIG.PLPHDVEV....AIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLL..RYSGE
  288-  331 (28.15/24.68)	FVQSAYLSRRLAYFCTRRLalqldGVSSHSSHVMSAQSTS.TLPA.....................................................................................................................................................................................................
  451-  520 (75.70/36.33)	.............................................tpapqpptssapstpfsdllmcpqhrplvfglscilqtillccpsalvwhysltdsriktgspldhlpiapsnlpmpegnsaftqqvraklreieqqikergqavevrwsfdkcqeataGFTIG.RVLHTLEVldshSFERSDFSNSL......DSLCNRIFGLGPSKDGHE.ISSDDDAVVSLLCEWAVscKRSGR
  524-  606 (108.97/59.28)	MVVAKLLEKRQAEIEAERC.....GESEAADEKGSIASGSlSAPS............................................................................................................................aPIFQDV.......LLQF.LDTQAPMLTDPRSESERVEFFNLVLLFCELIR......................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.54|      16|      22|     639|     660|       8
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  645-  660 (26.33/27.98)	SERKEAEGSSSSKLED
  664-  679 (28.21/11.92)	SESMDIDPSSSVLFED
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.35|      19|      22|    1652|    1672|       9
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 1652- 1672 (24.97/24.90)	EPQGSLIDTKgNKIAGFDsIF
 1673- 1691 (34.38/22.05)	KKEGLQVSTK.QKISPWD.LF
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.51|      32|     160|    1531|    1562|      10
---------------------------------------------------------------------------
 1531- 1562 (55.48/34.66)	EALKLRLNLVGGMFDTVQ..RSTQQTTEWAMLLL
 1692- 1725 (54.03/33.54)	EGLKPSAPLSWGWFGTVRvdRRVARGEEQQRLLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.26|      11|      23|    1564|    1574|      13
---------------------------------------------------------------------------
 1564- 1574 (20.16/11.62)	IIISGTV..DMQS
 1588- 1600 (15.10/ 6.93)	VLINGTLaaDMSS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     261.85|      82|     198|    1234|    1323|      16
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 1240- 1323 (139.36/101.01)	GFTVTGGTEELpeEEGGG.GSGGRRQGGR..NISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDS....NDLQD.PVLSSAQAQRLMQ
 1441- 1530 (122.49/71.70)	GHVLKAAGEEL..EKGQHlGSSSRKERDRqkQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVhqivNNWRDnQYLDDCKPKQLMH
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20592 with Med12 domain of Kingdom Metazoa
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