<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20591

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMENFSALFGAQADPPPPPTALSLGPGKPPPPPPPPPGGGPGSAPPPXKSAAGCGPFYLMRELPGSTQLTGSTNLITHYNLEHSYNKFCGKKVKEKLSNFLPDLPGMIDLPGSHDNSSLRSLIEKPPILGGSFNPITGTMLAGFRLHTGLLPEQCRLMHIQPPKKKNKHKYKQSRTQDPVPPETPSDSDHKKKKKKKEEDPERKRKKKEKKKKKNRHSPDHPGVGSSQASSSSSL
Length234
PositionHead
OrganismOdobenus rosmarus divergens (Pacific walrus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Odobenidae> Odobenus.
Aromaticity0.05
Grand average of hydropathy-1.007
Instability index62.83
Isoelectric point9.86
Molecular weight25259.69
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20591
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      66.47|      16|      16|     181|     196|       1
---------------------------------------------------------------------------
  163-  184 (21.96/ 8.43)	KKKNKHKYKQSRtqdpvpPETP
  185-  203 (20.31/ 7.31)	SDSDHKKKKKKK...eedPERK
  204-  221 (24.19/ 9.94)	RKKKEKKKKKNR....hsPDHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.95|      44|      46|      59|     104|       3
---------------------------------------------------------------------------
   59-  102 (79.03/48.79)	MRELPGSTQLTGSTNLITHYN.LEHSYNKFCGKKVKE.KL.SNFLPD
  106-  152 (64.92/33.37)	MIDLPGSHDNSSLRSLIEKPPiLGGSFNPITGTMLAGfRLhTGLLPE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20591 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FLPDLPGMIDLPGSHDNSSLRSLIEKPPILGGS
2) NFSALFGAQADPPPPPTALSLGPGKPPPPPPPPPGGGPGSAPPPXKSA
3) PEQCRLMHIQPPKKKNKHKYKQSRTQDPVPPETPSDSDHKKKKKKKEEDPERKRKKKEKKKKKNRHSPDHPGVGSSQASSSSSL
99
3
151
131
50
234










Molecular Recognition Features






MoRF SequenceStartStop




1) MAAFGI
2) NIFGRY
3) QQILRQQQ
4) QQQQYHIRQQ
1
2169
2089
2074
6
2174
2096
2083