<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20590

Description mediator of RNA polymerase II transcription subunit 12 isoform X3
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVIDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVMSAQSTSTLPATPAPQPPTSSAPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDSERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPYRLLDSEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDNQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGERQSDSLEKVLQLLPLPKPTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHTNPGSISHLSYRQGSIGLYTQNQPLPAGGPRMDSYRPVRLPMQKLPTRPPYPGVLPTTMTGVMGLEPSYKTSVYRQQQPAVPQGQRLRQQLQAKISQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLASTQRFSQQTLQQAPMIGAMTPLGAQGVQAGGVRSASILPEQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQQQQILRQQQQQQQQQQQQQQQQQAHQQQQQQQQAAPPQAQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2174
PositionKinase
OrganismOdobenus rosmarus divergens (Pacific walrus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Odobenidae> Odobenus.
Aromaticity0.07
Grand average of hydropathy-0.485
Instability index56.92
Isoelectric point6.75
Molecular weight242285.16
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20590
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     157.32|      15|      15|    2053|    2067|       1
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 2066- 2083 (22.41/ 6.79)	QQqQQQQQQQQQyhIRQQ
 2084- 2098 (31.76/12.75)	QQ.QQQQQILRQ..QQQQ
 2099- 2113 (32.49/13.22)	QQ.QQQQQQQQQ..QAHQ
 2114- 2127 (25.97/ 9.06)	QQ.QQQQQ.AAP..PQAQ
 2128- 2142 (21.60/ 6.27)	PQ.SQPQFQRQG..LQQT
 2143- 2157 (23.09/ 7.23)	QQ.QQQTAALVR..QLQQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.32|      16|      17|    1792|    1807|       2
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 1760- 1776 (21.55/ 8.61)	EKKAPePPKTDKPGAAP
 1791- 1806 (29.77/15.23)	KRSQP.ATKTEDYGMGP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.20|      25|      46|     346|     370|       3
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  346-  370 (47.16/27.32)	PFSDLLMCPQHRPLVFGLSCILQTI
  394-  418 (46.04/26.48)	PLDHLPIAPSNLPMPEGNSAFTQQV
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     319.48|     110|     232|     217|     336|       4
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  217-  287 (106.67/54.92)	....................................................................................................................................................................GSTIG.PLPHDVEV....AIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLL..RYSGE
  288-  331 (28.15/24.45)	FVQSAYLSRRLAYFCTRRLalqldGVSSHSSHVMSAQSTS.TLPA.....................................................................................................................................................................................................
  451-  520 (75.70/36.00)	.............................................tpapqpptssapstpfsdllmcpqhrplvfglscilqtillccpsalvwhysltdsriktgspldhlpiapsnlpmpegnsaftqqvraklreieqqikergqavevrwsfdkcqeataGFTIG.RVLHTLEVldshSFERSDFSNSL......DSLCNRIFGLGPSKDGHE.ISSDDDAVVSLLCEWAVscKRSGR
  524-  606 (108.97/58.77)	MVVAKLLEKRQAEIEAERC.....GESEAADEKGSIASGSlSAPS............................................................................................................................aPIFQDV.......LLQF.LDTQAPMLTDPRSESERVEFFNLVLLFCELIR......................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.20|      16|      17|     639|     655|       5
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  639-  655 (23.73/20.64)	DDPAdDSERKEAEGSSS
  659-  674 (29.48/19.99)	EDPG.LSESMDIDPSSS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.57|      16|      17|     860|     876|       6
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  860-  876 (26.03/17.11)	FALgMSYHLPLVQHVQF
  878-  893 (28.55/14.14)	FDL.MEYSLSISGLIDF
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     379.22|     120|     234|    1625|    1759|       7
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 1625- 1753 (164.79/116.59)	...................................GE............................................RQSdSLEKVLQLLPLPK..................PTRdvitcEPQGSLIDTKGNKIAGFDSIFK.................KEG...LQVSTKQKISPWDLFEGLKPSAplSWGWFGTVRVDRRVARGEEQQRLLLYHTHLrprPRAYYLEPLplppEDEEPPA
 1754- 1981 (160.93/81.96)	PTLLEPekkapeppktdkpgaappsteerkkkstkGKkrsqpatktedygmgpgrsgpygvtvppdllhhtnpgsishlsyRQG.SIGLYTQNQPLPAggprmdsyrpvrlpmqklPTR.....PPYPGVLPTTMTGVMGLEPSYKtsvyrqqqpavpqgqrlRQQ...LQAKISQGMLGQSSVHQMTPSS..SYGLQTSQGYTPYVSHVGLQQHTGPAGTMV...PPSYSSQPY....QSTHPST
 1983- 2024 (53.50/20.24)	PTLVDP................................................................................................................................................................trhLQ....QRPSGY..VHQQAPTY..GHGLASTQRF....SQQTLQQ................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.81|      32|      58|    1042|    1099|       8
---------------------------------------------------------------------------
 1065- 1098 (55.19/80.32)	GHHDPDRvnDIAILCAELTGYCKSL.....SAEWLG..VLK
 1261- 1299 (47.61/15.71)	GRRQGGR..NISVETASLDVYAKYVlrsicQQEWVGerCLK
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.08|      44|     200|    1326|    1376|      12
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 1326- 1376 (70.13/63.02)	CYPYRLLDSE........DGenpQRQRIKRILQNLDQWTMrqssLELQLMIKQT....PNNEM
 1523- 1578 (65.95/41.70)	CKPKQLMHEAlklrlnlvGG...MFDTVQRSTQQTTEWAM....LLLEIIISGTvdmqSNNEL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.14|      13|      17|    1028|    1040|      13
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 1028- 1040 (25.11/16.42)	ENPAA.HTFTYTGL
 1046- 1059 (21.03/12.48)	ENPANrYSFVCNAL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.39|      24|     200|    1234|    1259|      16
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 1234- 1259 (38.07/31.66)	AELKGS..GFTVTGGTEELpeEEGG..GGS
 1433- 1460 (32.33/18.98)	AKLPTSvqGHVLKAAGEEL..EKGQhlGSS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20590 with Med12 domain of Kingdom Metazoa
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