<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20589

Description mediator of RNA polymerase II transcription subunit 12 isoform X4
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVIDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVMSAQSTSTLPATPAPQPPTSSAPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDSERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPYRLLDSEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDNQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGERQSDSLEKVLQLLPLPKPTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHTNPGSISHLSYRQGSIGLYTQNQPLPAGGPRMDSYRPVRLPMQKLPTRPPYPGVLPTTMTGVMGLEPSYKTSVYRQQQPAVPQGQRLRQQLQAKISQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLASTQRFSQQTLQQAPMIGAMTPLGAQGVQAGGVRSASILPEQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQQQQILRQQQQQQQQQQQQQQQQAHQQQQQQQQAAPPQAQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2173
PositionKinase
OrganismOdobenus rosmarus divergens (Pacific walrus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Odobenidae> Odobenus.
Aromaticity0.07
Grand average of hydropathy-0.483
Instability index56.85
Isoelectric point6.75
Molecular weight242157.03
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20589
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     172.95|      16|      16|    2053|    2068|       1
---------------------------------------------------------------------------
 2052- 2064 (23.45/ 7.77)	...E......QQQQQQQQ..QQQQ
 2065- 2080 (34.52/15.10)	QQQQ......QQQQQQQQ..QYHI
 2081- 2096 (32.30/13.63)	RQQQ......QQQQQQIL..RQQQ
 2097- 2112 (35.81/15.95)	QQQQ......QQQQQQQQ..QAHQ
 2125- 2142 (24.90/ 8.73)	AQPQ......SQPQFQRQglQQTQ
 2143- 2164 (21.97/ 6.79)	QQQQtaalvrQLQQQLSN..TQPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.20|      25|      46|     346|     370|       2
---------------------------------------------------------------------------
  346-  370 (47.16/22.50)	PFSDLLMCPQHRPLVFGLSCILQTI
  394-  418 (46.04/21.80)	PLDHLPIAPSNLPMPEGNSAFTQQV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     341.18|      50|      56|    1806|    1855|       3
---------------------------------------------------------------------------
 1703- 1756 (42.26/20.15)	....GWFG.TVRVDrrvargeeqqrlL.......LY.HT...........HLRPRPRA..YYLEPLPLP....PEDeeppaPTL
 1759- 1801 (49.80/25.33)	PEKKAPE....PP......................K.TDKPGAAppS...TEERKKKSTKGKKRSQP......ATK.....TED
 1806- 1855 (98.22/58.67)	PGRSGPYGVTVPPD............L.......LH.HTNPGSI..S...HLSYRQGSIGLYTQNQPLP....AGG.....PRM
 1869- 1910 (63.75/34.94)	PTRP.PY.....PG............V.......LP.TTMTGVM..G..lEPSYK.TSV..YRQQQPAV....PQG.....QRL
 1923- 1954 (35.04/15.17)	LGQSSV.............................H.QMTPSS..............SYGLQTSQGYTPyvshVG........L
 1955- 2008 (52.10/26.92)	QQHTGPAGTMVPPS............YssqpyqsTHpSTNPTLV..DptrHLQQRPS..G.YVHQQA.P....TYG........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     319.48|     110|     231|     217|     336|       4
---------------------------------------------------------------------------
  217-  287 (106.67/58.83)	....................................................................................................................................................................GSTIG.PLPHDVEV....AIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLL..RYSGE
  288-  331 (28.15/26.13)	FVQSAYLSRRLAYFCTRRLalqldGVSSHSSHVMSAQSTS.TLPA.....................................................................................................................................................................................................
  451-  520 (75.70/38.53)	.............................................tpapqpptssapstpfsdllmcpqhrplvfglscilqtillccpsalvwhysltdsriktgspldhlpiapsnlpmpegnsaftqqvraklreieqqikergqavevrwsfdkcqeataGFTIG.RVLHTLEVldshSFERSDFSNSL......DSLCNRIFGLGPSKDGHE.ISSDDDAVVSLLCEWAVscKRSGR
  524-  606 (108.97/62.96)	MVVAKLLEKRQAEIEAERC.....GESEAADEKGSIASGSlSAPS............................................................................................................................aPIFQDV.......LLQF.LDTQAPMLTDPRSESERVEFFNLVLLFCELIR......................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.98|      39|      57|    1040|    1080|       6
---------------------------------------------------------------------------
 1040- 1080 (64.22/57.32)	LG..KSL...SENPANRYS.FVCNALMHvCVGHHDpDRVNDIAILCA
 1094- 1138 (53.77/37.39)	LGvlKALccsSNNGTCGFNdLLCNVDVS.DLSFHD.SLATFVAILIA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.15|      30|      50|    1465|    1496|       7
---------------------------------------------------------------------------
 1465- 1496 (46.68/35.83)	RDRQ...KQKSMSLLSQQpfLSLVLTCLKGQ.DE.QR
 1515- 1549 (40.47/23.34)	RDNQyldDCKPKQLMHEA..LKLRLNLVGGMfDTvQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.70|      14|      23|    1561|    1574|       8
---------------------------------------------------------------------------
 1561- 1574 (24.50/15.82)	LLEIIISGTV..DMQS
 1585- 1600 (20.20/11.74)	MLSVLINGTLaaDMSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.99|      38|      59|     622|     659|       9
---------------------------------------------------------------------------
  622-  659 (65.97/33.77)	RGDLAFGAPG.PRPPSPFDDPADDSERKEAEGSSSSKLE
  682-  720 (64.02/32.52)	KPDFSLFSPTmPCEGKGSPSPEKPDVEKEVKPPPKEKIE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.82|      23|     200|    1234|    1264|      11
---------------------------------------------------------------------------
 1240- 1264 (37.13/35.46)	GFTVTGGTEELpeEEGGG.GSGGRRQ
 1441- 1464 (35.69/14.45)	GHVLKAAGEEL..EKGQHlGSSSRKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.38|      13|      16|     864|     879|      15
---------------------------------------------------------------------------
  864-  876 (24.86/20.85)	MSYHLPLVQHVQF
  881-  893 (22.52/ 8.19)	MEYSLSISGLIDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      25.60|       8|      16|    1671|    1680|      18
---------------------------------------------------------------------------
 1671- 1680 (10.11/13.20)	IFkkEGLQVS
 1690- 1697 (15.50/ 9.88)	LF..EGLKPS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20589 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLY
2) GAPGPRPPSPFDDPADDSERKEAEGSSSSKLEDPGLSESMDIDPSSSV
3) KRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKN
4) LEPSYKTSVYRQQQPAVPQGQRLRQQLQAKISQGMLGQSSVHQMTPSSSYGLQTSQ
5) RAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHTNPGSISHLSYRQGSIGLYTQNQPLPAGGPRMDSYRPVRLPMQKLPTRPPYPGVLPTTMTGV
6) YVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLASTQRFSQQTLQQAPMIGAMTPLGAQGVQAGGVRSASILPEQQQQQQQQQQQQQQ
688
628
15
1888
1735
1948
727
675
61
1943
1885
2066










Molecular Recognition Features






MoRF SequenceStartStop




1) MAAFGI
2) NIFGRY
3) QQILRQQQ
4) QQQQYHIRQQ
1
2168
2089
2074
6
2173
2096
2083