<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20589

Description mediator of RNA polymerase II transcription subunit 12 isoform X4
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVIDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVMSAQSTSTLPATPAPQPPTSSAPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDSERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPYRLLDSEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDNQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGERQSDSLEKVLQLLPLPKPTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHTNPGSISHLSYRQGSIGLYTQNQPLPAGGPRMDSYRPVRLPMQKLPTRPPYPGVLPTTMTGVMGLEPSYKTSVYRQQQPAVPQGQRLRQQLQAKISQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLASTQRFSQQTLQQAPMIGAMTPLGAQGVQAGGVRSASILPEQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQQQQILRQQQQQQQQQQQQQQQQAHQQQQQQQQAAPPQAQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2173
PositionKinase
OrganismOdobenus rosmarus divergens (Pacific walrus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Odobenidae> Odobenus.
Aromaticity0.07
Grand average of hydropathy-0.483
Instability index56.85
Isoelectric point6.75
Molecular weight242157.03
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20589
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     172.95|      16|      16|    2053|    2068|       1
---------------------------------------------------------------------------
 2052- 2064 (23.45/ 7.77)	...E......QQQQQQQQ..QQQQ
 2065- 2080 (34.52/15.10)	QQQQ......QQQQQQQQ..QYHI
 2081- 2096 (32.30/13.63)	RQQQ......QQQQQQIL..RQQQ
 2097- 2112 (35.81/15.95)	QQQQ......QQQQQQQQ..QAHQ
 2125- 2142 (24.90/ 8.73)	AQPQ......SQPQFQRQglQQTQ
 2143- 2164 (21.97/ 6.79)	QQQQtaalvrQLQQQLSN..TQPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.20|      25|      46|     346|     370|       2
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  346-  370 (47.16/22.50)	PFSDLLMCPQHRPLVFGLSCILQTI
  394-  418 (46.04/21.80)	PLDHLPIAPSNLPMPEGNSAFTQQV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     341.18|      50|      56|    1806|    1855|       3
---------------------------------------------------------------------------
 1703- 1756 (42.26/20.15)	....GWFG.TVRVDrrvargeeqqrlL.......LY.HT...........HLRPRPRA..YYLEPLPLP....PEDeeppaPTL
 1759- 1801 (49.80/25.33)	PEKKAPE....PP......................K.TDKPGAAppS...TEERKKKSTKGKKRSQP......ATK.....TED
 1806- 1855 (98.22/58.67)	PGRSGPYGVTVPPD............L.......LH.HTNPGSI..S...HLSYRQGSIGLYTQNQPLP....AGG.....PRM
 1869- 1910 (63.75/34.94)	PTRP.PY.....PG............V.......LP.TTMTGVM..G..lEPSYK.TSV..YRQQQPAV....PQG.....QRL
 1923- 1954 (35.04/15.17)	LGQSSV.............................H.QMTPSS..............SYGLQTSQGYTPyvshVG........L
 1955- 2008 (52.10/26.92)	QQHTGPAGTMVPPS............YssqpyqsTHpSTNPTLV..DptrHLQQRPS..G.YVHQQA.P....TYG........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     319.48|     110|     231|     217|     336|       4
---------------------------------------------------------------------------
  217-  287 (106.67/58.83)	....................................................................................................................................................................GSTIG.PLPHDVEV....AIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLL..RYSGE
  288-  331 (28.15/26.13)	FVQSAYLSRRLAYFCTRRLalqldGVSSHSSHVMSAQSTS.TLPA.....................................................................................................................................................................................................
  451-  520 (75.70/38.53)	.............................................tpapqpptssapstpfsdllmcpqhrplvfglscilqtillccpsalvwhysltdsriktgspldhlpiapsnlpmpegnsaftqqvraklreieqqikergqavevrwsfdkcqeataGFTIG.RVLHTLEVldshSFERSDFSNSL......DSLCNRIFGLGPSKDGHE.ISSDDDAVVSLLCEWAVscKRSGR
  524-  606 (108.97/62.96)	MVVAKLLEKRQAEIEAERC.....GESEAADEKGSIASGSlSAPS............................................................................................................................aPIFQDV.......LLQF.LDTQAPMLTDPRSESERVEFFNLVLLFCELIR......................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.98|      39|      57|    1040|    1080|       6
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 1040- 1080 (64.22/57.32)	LG..KSL...SENPANRYS.FVCNALMHvCVGHHDpDRVNDIAILCA
 1094- 1138 (53.77/37.39)	LGvlKALccsSNNGTCGFNdLLCNVDVS.DLSFHD.SLATFVAILIA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.15|      30|      50|    1465|    1496|       7
---------------------------------------------------------------------------
 1465- 1496 (46.68/35.83)	RDRQ...KQKSMSLLSQQpfLSLVLTCLKGQ.DE.QR
 1515- 1549 (40.47/23.34)	RDNQyldDCKPKQLMHEA..LKLRLNLVGGMfDTvQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.70|      14|      23|    1561|    1574|       8
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 1561- 1574 (24.50/15.82)	LLEIIISGTV..DMQS
 1585- 1600 (20.20/11.74)	MLSVLINGTLaaDMSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.99|      38|      59|     622|     659|       9
---------------------------------------------------------------------------
  622-  659 (65.97/33.77)	RGDLAFGAPG.PRPPSPFDDPADDSERKEAEGSSSSKLE
  682-  720 (64.02/32.52)	KPDFSLFSPTmPCEGKGSPSPEKPDVEKEVKPPPKEKIE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.82|      23|     200|    1234|    1264|      11
---------------------------------------------------------------------------
 1240- 1264 (37.13/35.46)	GFTVTGGTEELpeEEGGG.GSGGRRQ
 1441- 1464 (35.69/14.45)	GHVLKAAGEEL..EKGQHlGSSSRKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.38|      13|      16|     864|     879|      15
---------------------------------------------------------------------------
  864-  876 (24.86/20.85)	MSYHLPLVQHVQF
  881-  893 (22.52/ 8.19)	MEYSLSISGLIDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      25.60|       8|      16|    1671|    1680|      18
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 1671- 1680 (10.11/13.20)	IFkkEGLQVS
 1690- 1697 (15.50/ 9.88)	LF..EGLKPS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20589 with Med12 domain of Kingdom Metazoa
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