<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20588

Description mediator of RNA polymerase II transcription subunit 12 isoform X6
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVIDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVMSAQSTSTLPATPAPQPPTSSAPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDSERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPYRLLDSEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDNQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGERQSDSLEKVLQLLPLPKPTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHTNPGSISHLSYRQGSIGLYTQNQPLPAGGPRMDSYRPVRLPMQKLPTRPPYPGVLPTTMTGVMGLEPSYKTSVYRQQQPAVPQGQRLRQQLQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLASTQRFSQQTLQQAPMIGAMTPLGAQGVQAGGVRSASILPEQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQQQQILRQQQQQQQQQQQQQQQQQAHQQQQQQQQAAPPQAQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2171
PositionKinase
OrganismOdobenus rosmarus divergens (Pacific walrus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Odobenidae> Odobenus.
Aromaticity0.07
Grand average of hydropathy-0.487
Instability index57.23
Isoelectric point6.70
Molecular weight241972.76
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20588
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     179.84|      15|      15|    2050|    2064|       1
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 2050- 2064 (35.14/12.56)	QQQQQQ..QQQ...QQQQQQ
 2066- 2083 (28.80/ 9.08)	QQQQQQ..QQQyhiRQQQQQ
 2084- 2098 (31.04/10.31)	QQQQIL..RQQ...QQQQQQ
 2099- 2113 (33.36/11.58)	QQQQQQ..QQQ...AHQQQQ
 2114- 2128 (27.71/ 8.48)	QQQQAA..PPQ...AQPQSQ
 2129- 2145 (23.78/ 6.33)	PQFQRQglQQT...QQQQQT
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.20|      25|      46|     346|     370|       2
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  346-  370 (47.16/29.56)	PFSDLLMCPQHRPLVFGLSCILQTI
  394-  418 (46.04/28.65)	PLDHLPIAPSNLPMPEGNSAFTQQV
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     319.48|     110|     231|     217|     336|       3
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  217-  287 (106.67/62.69)	....................................................................................................................................................................GSTIG.PLPHDVEV....AIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLL..RYSGE
  288-  331 (28.15/27.99)	FVQSAYLSRRLAYFCTRRLalqldGVSSHSSHVMSAQSTS.TLPA.....................................................................................................................................................................................................
  451-  520 (75.70/41.15)	.............................................tpapqpptssapstpfsdllmcpqhrplvfglscilqtillccpsalvwhysltdsriktgspldhlpiapsnlpmpegnsaftqqvraklreieqqikergqavevrwsfdkcqeataGFTIG.RVLHTLEVldshSFERSDFSNSL......DSLCNRIFGLGPSKDGHE.ISSDDDAVVSLLCEWAVscKRSGR
  524-  606 (108.97/67.07)	MVVAKLLEKRQAEIEAERC.....GESEAADEKGSIASGSlSAPS............................................................................................................................aPIFQDV.......LLQF.LDTQAPMLTDPRSESERVEFFNLVLLFCELIR......................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.00|      18|      18|    1734|    1751|       4
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 1734- 1751 (34.55/16.11)	PRAYYLEP...LPLPPEDEEP
 1752- 1772 (25.76/ 9.93)	PAPTLLEPekkAPEPPKTDKP
 1795- 1811 (27.69/11.28)	P.ATKTED...YGMGPGRSGP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     474.35|     137|     149|     869|    1017|       5
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  792-  865 (74.20/37.57)	....................................................................................DQLAPIVPLNPGDLTF........LGGEDGQKRRRNrpeAFPTAEDIFAKFQHL.SHYDQ..HQV..TAQVSRNV..LEQITSFALGMS
  869- 1017 (211.31/158.77)	PlvqhvQFIFDLME....YSLSISGL.IDFAIQLLNELSVVEAELLlksSDLVGSYTTS.....LCLCivAVLRHYhaCLILNQDQMAQVFEGLCGVVKHG.......MNRSDGSSAERC...ILAYLYDLYTSCSHLKSKFGELFSDF..CSKVKNTI..YCNVEPSESNMR
 1020- 1171 (188.85/116.50)	P.....EFMIDTLEnpaaHTFTYTGLgKSLSENPANRYSFVCNALM...HVCVGHHDPDrvndiAILC..AELTGY..CKSLSAEWLG.VLKALCCSSNNGtcgfndlLCNVDVSD........LSFHDSLATFVAILIARQCLLLEDLirCAAIPSLLnaACSEQDSEPGAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     107.17|      19|      19|    1991|    2009|       6
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 1870- 1889 (21.64/ 6.89)	TRPP.YpgVLPTTMTGVMGLE
 1892- 1909 (25.26/ 9.51)	YKTSVY...RQQQPAVPQGQR
 1991- 2009 (37.66/18.48)	QRPSGY..VHQQAPTYGHGLA
 2012- 2027 (22.60/ 7.59)	QRFSQQ..TLQQAPMIG...A
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.17|      19|      19|     645|     663|       7
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  641-  660 (27.91/16.97)	PAdDSERKEAEGSSSSKLED
  661-  679 (34.26/22.87)	PG.LSESMDIDPSSSVLFED
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.14|      21|      23|    1944|    1964|       8
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 1841- 1856 (22.00/ 7.71)	LYTqNQPL........PAGGPRMD
 1944- 1964 (40.82/20.86)	PYV.SHVGLQQH..TGPAGTMVPP
 1965- 1985 (31.32/14.22)	SYS.SQPYQSTHpsTNP..TLVDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.70|      14|      23|    1561|    1574|      11
---------------------------------------------------------------------------
 1561- 1574 (24.50/17.23)	LLEIIISGTV..DMQS
 1585- 1600 (20.20/12.76)	MLSVLINGTLaaDMSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.11|      24|     230|    1376|    1424|      13
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 1377- 1400 (37.76/50.90)	NSLLENIAKATIEVFQQSAETGSS
 1437- 1460 (39.35/ 7.06)	TSVQGHVLKAAGEELEKGQHLGSS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.86|      15|      19|    1660|    1678|      14
---------------------------------------------------------------------------
 1660- 1678 (14.83/24.03)	TKgNKIAGFDsIFkkEGLQ
 1681- 1695 (30.03/19.10)	TK.QKISPWD.LF..EGLK
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.39|      39|     201|    1283|    1357|      17
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 1317- 1355 (70.39/95.01)	QAQRLMQLIC.YPY..RLLDSEDGENPQRQRI.....KRILQNLDQW
 1468- 1514 (53.00/13.73)	QKQKSMSLLSqQPFlsLVLTCLKGQDEQREGLltslySQVHQIVNNW
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.40|      24|      24|     695|     718|      19
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  695-  718 (43.12/24.92)	EGKGSPSPEKP.DVEKEVK.PPPKEK
  720-  745 (35.28/18.86)	EGTLGVLYDQPrHVQYATHfPIPQEE
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20588 with Med12 domain of Kingdom Metazoa
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