Description | Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MYLALQSLEQDLSKMAVMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYASPSDLLDDKTTSPIILHENNVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYVPLYELITQFELSKDPDPLPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILSLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICPGSNKTKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFNPDLLNSQSQGGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNSQADTVDFSIISVAGKALGPADLMEHHSGSQSPLLTTGDLGKEKTQKRVKEGNGTSNSSLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSSASNSGKMKSSKSEGSSSSKLSSSVYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPAGSDKLASPMKAVPGTPPSSKAKSPISSGSGGSHMSGTSSSTGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKEKSKVSTSGGSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSLTSNTILSTDRPSRLSPDFMIGEEDDDLMDVALIGN |
Length | 1410 |
Position | Middle |
Organism | Odobenus rosmarus divergens (Pacific walrus) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Odobenidae> Odobenus. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.701 |
Instability index | 54.70 |
Isoelectric point | 8.95 |
Molecular weight | 149197.29 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP20586 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 8| 740.88| 99| 100| 936| 1034| 1 --------------------------------------------------------------------------- 477- 578 (77.41/16.36) .......LKDNPAQD..F...........STLYGS...S.P..........LER.....QNSSSGSP......RM....EIC................................PG..SNK......TKKK.KSSRLPPDKPKHQT............EDDfqrelfsmdvdsqnpifdvNMTADTLDTPHI..TP.APS............QcstPP.......T 590- 711 (72.98/14.95) SIQRMVRLSSSDSIG..PdvtdilsdiaeEASKLP...S.TsddcppigtpVRD.....S.SSSGHS......QSalfdPDVF.Q........tnnnenpytdpadliadAAGSPS..SDS..P...TNHF.FPDG...VDFNPD....................................LLN.............SQS............Q...GGF..GEEYF 713- 835 (75.48/15.75) ESSQSGDNDDFK..G..F...........ASQALN...TlG..........VPM.....LGGDNGET......KF....KGNS.QadtvdfsiisvagkalgpadlmehhSGSQ.....SP..L...LTTGdLGKEKTQKRVK.EG............NGT...................S..NSSLSGPGLdsKPgKRS............R...TPSndGKSKD 836- 932 (105.88/25.42) K...PPKRKKADTEG..K...........SPSHSS...S.N.........rPFT.....PPTSTGGS......KS....PGSSgR.........................SQTPPGvaTPP..I...PKIT.IQIPKGTVMV...G............KPS...................HSQYTSSGSVSS..SG.SKS............H...HSH..SSSSS 936- 1034 (172.00/46.44) SASNSGKMKSSKSEG..S...........SSSKLS...S.S..........VYS.....SQGSSGSS......QS....KNSS.Q.........................SGGKPG..SSP..I...TKHG.LSSGSSSTKMKPQG............KPS...................SLMNPSLSKPNI..SP.SHS............R...PPA..GSDKL 1091- 1170 (72.71/14.87) .........SSNSCT..A...........SSSSFSssgS.S..........MSS.....SQNQHGSS......KG....KSPS.R.........................N.KKPS..LTA..VidkLKHGvVTSG.......PGG............E........................DPMDGQMGV..ST.NSS............S...HPM..S.... 1171- 1259 (84.53/18.63) ...SKHNMSGGEFQGkrE...........KSDKEK...S.K..........VST.....SGGSVDSS......KK....TSES.K.........................NVGSTG..VAKiiI...SKH...DGGSPSIKAK.........................................VTLQKPGE..SS.GEG...........lR...PQM..ASSKN 1262- 1386 (79.89/17.15) SPLISG..STPKHER..G...........SPSHSK...S.P..........AYTpqnldSESESGSSiaeksyQN....SPSS.D.........................DGIRPL..PEY..S...TEKH.KKHKKEKKKVKDKDrdrdrdkdrdkkKSH...................SIKPESWSKSPI..SS.DQSlsltsntilstdR...P......... --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 43.35| 12| 169| 145| 156| 2 --------------------------------------------------------------------------- 145- 156 (24.01/14.46) FVQK.LQNCTGIP 321- 333 (19.33/10.31) FIAKvVQRCMSIP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 78.75| 25| 110| 253| 304| 6 --------------------------------------------------------------------------- 224- 251 (34.03/62.55) ITFQHPGRVPLILSLIrhQVAYNTLIgS 280- 304 (44.72/17.86) VSFQHPVNDSLVCVVM..DVQDSTHV.S --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 39.00| 12| 117| 421| 432| 8 --------------------------------------------------------------------------- 421- 432 (23.63/15.93) EDFS.KV.SQNPIL 539- 552 (15.37/ 7.15) ELFSmDVdSQNPIF --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 97.00| 18| 21| 369| 386| 9 --------------------------------------------------------------------------- 369- 386 (39.07/18.81) PPASSPGYGMTTGNNPMS 391- 407 (32.36/14.21) PTNTFPGGPITTLFN.MS 458- 472 (25.57/ 9.55) PPVSS.MAG.NTKNHPM. --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 87.21| 29| 54| 112| 140| 12 --------------------------------------------------------------------------- 111- 139 (53.19/32.58) K.......................WTPSFSSIT....SANSVDLPACFFLKFPQPI 140- 195 (34.02/17.92) PvsrafvqklqnctgiplfetqptYVPLYELITqfelSKDPDPLPLNHNMRFYAAL --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) GEEYF 2) IKAKVTL 3) IRPLPEYSTEKHKKHKKEKKKVKDKDRD 4) KIIIS 5) KPSLTAVIDKLKHGV 6) LSPDFMIGEEDDDLMD 7) PKITIQIPK | 707 1233 1315 1220 1129 1389 889 | 711 1239 1342 1224 1143 1404 897 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab