<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20586

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMYLALQSLEQDLSKMAVMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYASPSDLLDDKTTSPIILHENNVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYVPLYELITQFELSKDPDPLPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILSLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICPGSNKTKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFNPDLLNSQSQGGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNSQADTVDFSIISVAGKALGPADLMEHHSGSQSPLLTTGDLGKEKTQKRVKEGNGTSNSSLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSSASNSGKMKSSKSEGSSSSKLSSSVYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPAGSDKLASPMKAVPGTPPSSKAKSPISSGSGGSHMSGTSSSTGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKEKSKVSTSGGSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSLTSNTILSTDRPSRLSPDFMIGEEDDDLMDVALIGN
Length1410
PositionMiddle
OrganismOdobenus rosmarus divergens (Pacific walrus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Odobenidae> Odobenus.
Aromaticity0.04
Grand average of hydropathy-0.701
Instability index54.70
Isoelectric point8.95
Molecular weight149197.29
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20586
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     740.88|      99|     100|     936|    1034|       1
---------------------------------------------------------------------------
  477-  578 (77.41/16.36)	.......LKDNPAQD..F...........STLYGS...S.P..........LER.....QNSSSGSP......RM....EIC................................PG..SNK......TKKK.KSSRLPPDKPKHQT............EDDfqrelfsmdvdsqnpifdvNMTADTLDTPHI..TP.APS............QcstPP.......T
  590-  711 (72.98/14.95)	SIQRMVRLSSSDSIG..PdvtdilsdiaeEASKLP...S.TsddcppigtpVRD.....S.SSSGHS......QSalfdPDVF.Q........tnnnenpytdpadliadAAGSPS..SDS..P...TNHF.FPDG...VDFNPD....................................LLN.............SQS............Q...GGF..GEEYF
  713-  835 (75.48/15.75)	ESSQSGDNDDFK..G..F...........ASQALN...TlG..........VPM.....LGGDNGET......KF....KGNS.QadtvdfsiisvagkalgpadlmehhSGSQ.....SP..L...LTTGdLGKEKTQKRVK.EG............NGT...................S..NSSLSGPGLdsKPgKRS............R...TPSndGKSKD
  836-  932 (105.88/25.42)	K...PPKRKKADTEG..K...........SPSHSS...S.N.........rPFT.....PPTSTGGS......KS....PGSSgR.........................SQTPPGvaTPP..I...PKIT.IQIPKGTVMV...G............KPS...................HSQYTSSGSVSS..SG.SKS............H...HSH..SSSSS
  936- 1034 (172.00/46.44)	SASNSGKMKSSKSEG..S...........SSSKLS...S.S..........VYS.....SQGSSGSS......QS....KNSS.Q.........................SGGKPG..SSP..I...TKHG.LSSGSSSTKMKPQG............KPS...................SLMNPSLSKPNI..SP.SHS............R...PPA..GSDKL
 1091- 1170 (72.71/14.87)	.........SSNSCT..A...........SSSSFSssgS.S..........MSS.....SQNQHGSS......KG....KSPS.R.........................N.KKPS..LTA..VidkLKHGvVTSG.......PGG............E........................DPMDGQMGV..ST.NSS............S...HPM..S....
 1171- 1259 (84.53/18.63)	...SKHNMSGGEFQGkrE...........KSDKEK...S.K..........VST.....SGGSVDSS......KK....TSES.K.........................NVGSTG..VAKiiI...SKH...DGGSPSIKAK.........................................VTLQKPGE..SS.GEG...........lR...PQM..ASSKN
 1262- 1386 (79.89/17.15)	SPLISG..STPKHER..G...........SPSHSK...S.P..........AYTpqnldSESESGSSiaeksyQN....SPSS.D.........................DGIRPL..PEY..S...TEKH.KKHKKEKKKVKDKDrdrdrdkdrdkkKSH...................SIKPESWSKSPI..SS.DQSlsltsntilstdR...P.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.35|      12|     169|     145|     156|       2
---------------------------------------------------------------------------
  145-  156 (24.01/14.46)	FVQK.LQNCTGIP
  321-  333 (19.33/10.31)	FIAKvVQRCMSIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.75|      25|     110|     253|     304|       6
---------------------------------------------------------------------------
  224-  251 (34.03/62.55)	ITFQHPGRVPLILSLIrhQVAYNTLIgS
  280-  304 (44.72/17.86)	VSFQHPVNDSLVCVVM..DVQDSTHV.S
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.00|      12|     117|     421|     432|       8
---------------------------------------------------------------------------
  421-  432 (23.63/15.93)	EDFS.KV.SQNPIL
  539-  552 (15.37/ 7.15)	ELFSmDVdSQNPIF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.00|      18|      21|     369|     386|       9
---------------------------------------------------------------------------
  369-  386 (39.07/18.81)	PPASSPGYGMTTGNNPMS
  391-  407 (32.36/14.21)	PTNTFPGGPITTLFN.MS
  458-  472 (25.57/ 9.55)	PPVSS.MAG.NTKNHPM.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.21|      29|      54|     112|     140|      12
---------------------------------------------------------------------------
  111-  139 (53.19/32.58)	K.......................WTPSFSSIT....SANSVDLPACFFLKFPQPI
  140-  195 (34.02/17.92)	PvsrafvqklqnctgiplfetqptYVPLYELITqfelSKDPDPLPLNHNMRFYAAL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20586 with Med1 domain of Kingdom Metazoa
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