<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20582

Description Mediator of RNA polymerase II transcription subunit 8
SequenceMALWVTNLFLSVQREEKQLEASLDALLSQVADLKNSLGSFIYKLENEYDRLTCFALLSGQLNTLNKVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARVGADAAQKQIQSLNKMCSNLLEKISKEERESESGGLRPNKQTFNPADTNALVAAVAFGKGLSNWRPSGSSGPGQPGQPGAGTILAGTSGLQQVQMAGAPSQQQPLLSGVQMAQTGQTGKMPSGIKTNIKSASMHPYQR
Length273
PositionHead
OrganismLeptonychotes weddellii (Weddell seal) (Otaria weddellii)
KingdomMetazoa
Lineage
Aromaticity0.04
Grand average of hydropathy-0.490
Instability index44.27
Isoelectric point6.92
Molecular weight29758.40
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20582
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.34|      27|      28|     195|     221|       1
---------------------------------------------------------------------------
  164-  188 (22.40/ 6.76)	.....RESESGGlrPNkQTFNPADTNALVA
  195-  221 (52.47/23.55)	GLSNWRPSGSSG..PG.QPGQPGAGTILAG
  224-  243 (35.46/14.05)	GLQQVQMAGA....PS.QQ.QP....LLSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.18|      25|      28|      72|      97|       2
---------------------------------------------------------------------------
   72-   97 (40.28/29.86)	KTPLFRNQViIP..LVLSPDRD.EDLMRQ
  101-  128 (35.90/21.76)	RVPVFSHEV.VPdhLRTKPDPEvEEQEKQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20582 with Med8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FSHEVVPDHLRTKPDPEVEEQEKQLTTDAARVGADA
2) LSNWRPSGSSGPGQPGQPGAGTILAGTSGLQQVQMAGAPSQQQPLLSGVQMAQTGQTGKMPSGIKTNIKSASMHPYQR
105
196
140
273










Molecular Recognition Features






MoRF SequenceStartStop




1) KSASMHPYQR
264
273