<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20576

Description mediator of RNA polymerase II transcription subunit 26
SequenceMTAAPASPQQIRDRLLQAIDPQSNIRNMVAVLEVISSLEKYPITKEALEETRLGKLINDVRKKTKNEELAKRAKKLLRSWQKLIEPVHQNEAALRGLAGSTGSANGGAHNCRPEGGAAGAPKSIHELKNRNDIQRLPGQRLDRLGSRKRRGDQRDLGHPGPPPKVSKASHDSLVPNSSPLPTNGIGGSPESFPGALDGSGHVGPEGSRLEHGDSDKHSGKIPVNAVRPHTSSPGLGKPPGPCLQTKAAVLQQLDRVDETPGPPHPKGPPRCSLSPRNSRHEGSFARQRSPYTPKGSLASPSPRPQALEATQVPSPLPPARPSTPPVRRLELLPSAESPVRWLEQPEGHQRLAGQGCKGGLPPAEPLLPRAGFSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPVRADSPVHTEQPRTELDKPEAKASVQSPFEQTNWKELSRNEIIQSYLSRQSSLLSSSGAQTPGAHHFMSEYLKQEESTRRGARKPHVLVPHSAPSDLPGLNREVTQDDLDRIQAHQWPGVNGCQDTQGNWYDWTQCISLDPHGDDGRLNILPYVCLD
Length599
PositionUnknown
OrganismLeptonychotes weddellii (Weddell seal) (Otaria weddellii)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Phocidae> Leptonychotes.
Aromaticity0.03
Grand average of hydropathy-0.885
Instability index58.58
Isoelectric point9.53
Molecular weight65182.42
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20576
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     398.67|      91|      98|     102|     196|       1
---------------------------------------------------------------------------
  102-  196 (156.93/52.31)	GSANGGAHNCRPEGGAAGAP......KSIHELKNRNDIQRLPG..........QRLDRLGSRKRRGDqrdlGHPGPPPKVS....KASHD.SLVPNSSPLPTNGI..GGSPESFPGAL
  198-  307 (134.60/40.20)	GSGHVGPEGSRLEHGDSDKHsgkipvNAVRPHTSSPGLGKPPGpclqtkaavlQQLDRVD..ETPGP....PHPKGPPRCSlsprNSRHEgSFARQRSPYTPKGS..LASPSPRPQAL
  317-  389 (107.14/30.73)	PPARPSTPPVRRLELLPSAE......SPVRWLEQPEGHQRLAG..........Q.....GCKG........GLPPAEPLLP....RA....GFSPDSSKADSDAAssGGS........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.57|      15|      22|     488|     504|       3
---------------------------------------------------------------------------
  488-  504 (21.68/17.28)	YLSRQSSllSSSGAQTP
  513-  527 (26.89/15.07)	YLKQEES..TRRGARKP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20576 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HQNEAALRGLAGSTGSANGGAHNCRPEGGAAGAPKSIHELKNRNDIQRLPGQRLDRLGSRKRRGDQRDLGHPGPPPKVSKASHDSLVPNSSPLPTNGIGGSPESFPGALDGSGHVGPEGSRLEHGDSDKHSGKIPVNAVRPHTSSPGLGKPPGPCLQTKAAVLQQLDRVDETPGPPHPKGPPRCSLSPRNSRHEGSFARQRSPYTPKGSLASPSPRPQALEATQVPSPLPPARPSTPPVRRLELLPSAESPVRWLEQPEGHQRLAGQGCKGGLPPAEPLLPRAGFSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPVRADSPVHTEQPRTELDKPEAKASVQSPFEQTNW
2) QSSLLSSSGAQTPGAHHFMSEYLKQEESTRRGARKPHVLVPHSAPSDLPGLNREVTQDDLDRIQAHQWP
88
492
476
560










Molecular Recognition Features






MoRF SequenceStartStop




1) IRDRLL
2) KKKKRYRPRDYTVNLD
3) VRRLELLP
11
392
326
16
407
333