<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20574

Description mediator of RNA polymerase II transcription subunit 12-like
SequenceMEISALGTHSGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPYRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSAASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDNQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGERQSDSLEKVLQLLPLPKPTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHLSYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPPYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLASTQRAKWRKQDWKMPRHEGYEPLKRGDVFAPYSPTEKSVRTQKGPSGYSARRNE
Length1270
PositionKinase
OrganismLeptonychotes weddellii (Weddell seal) (Otaria weddellii)
KingdomMetazoa
Lineage
Aromaticity0.06
Grand average of hydropathy-0.441
Instability index50.93
Isoelectric point8.08
Molecular weight140820.60
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20574
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     167.57|      29|      29|     947|     975|       1
---------------------------------------------------------------------------
  947-  975 (52.56/28.90)	PPEDEEPPAPTLLEPEKKAP.............EPPKTDKPG
  978- 1005 (39.26/19.57)	PPSTEERKKKS.TKGKKRSQ.............PATKTEDYG
 1012- 1052 (35.31/16.80)	GPYGVTVP.PDLLHHANPGSishlsyrqgsiglYTQNQPLPA
 1053- 1078 (40.43/20.39)	GGPRVDPYRPVRL.PMQKLP............tRPP...YPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     181.30|      32|     103|    1081|    1112|       2
---------------------------------------------------------------------------
 1081- 1112 (57.83/36.60)	PTTMTGV...MG.LE..P.SSYKTSVYRQQQPAVPQG....QR
 1137- 1160 (22.08/ 8.18)	PSSSYGLqtsQG.YT..P...YVSHVGLQQ.............
 1162- 1184 (21.55/ 7.76)	....TGP...AGtMV..P.PSYSSQPYQSTHPS..........
 1187- 1220 (38.74/21.43)	PTLVDPT...RH.LQqrP.SGY....VHQQAPTYGHGlastQR
 1238- 1268 (41.11/23.31)	PLKRGDV......FA..PySPTEKSVRTQKGPSGYSA....RR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     143.73|      30|      38|     274|     303|       3
---------------------------------------------------------------------------
  169-  194 (22.54/ 9.75)	AERCILA..ylYDLYTSCSHLKSKF.GEL...........
  229-  264 (35.47/19.70)	ENPAAHT....FTYTGLGKSLSENPANRYSFVCnalmhvC
  274-  303 (53.66/33.69)	NDIAILC....AELTGYCKSLSAEWLGVLKALC......C
  313-  342 (32.06/17.07)	ND..LLCnvdvSDLS.FHDSL.ATFVAILIARQ......C
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     231.71|      82|     126|     674|     765|       4
---------------------------------------------------------------------------
  674-  765 (114.90/91.48)	SMSLL...................SQQPFLSLVlTCLKGQDEQREGllTSLySQVHQIVNNWRDNQYLDDCKPKQLMheaLKLRLNLVGGmFDTV......QRST.QQTTEWAmlLLE
  787-  894 (116.81/64.17)	MLSVLingtlaadmssisqgsmeeNKRAYMNLV.KKLRKELGERQS..DSL.EKVLQLLPLPKPTRDVITCEPQGSL...IDTKGNKIAG.FDSIfkkeglQVSTkQKISPWD..LFE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20574 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHLSYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPPYPGVLPTTMTGVM
2) LEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLASTQRAKWRKQDWKMPRHEGYEPLKRGDVFAPYSPTEKSVRTQKGPSGYSARRNE
938
1090
1088
1270










Molecular Recognition Features






MoRF SequenceStartStop




1) YEPLKRGDVFAPYS
1236
1249