<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20573

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEELKEDEELGYNDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVAGAGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAVIGESGGTQSAVSHLGSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPANNPATWDFVDPTQRVSCSCSRITLSETYGILVGIALNLYINLGRIMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWSSEENDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQSPPAAAQGQATPGNAGPLASNSGSAAPSTGSAFNPTSNSSAGNPAASSSASGSSVPPVSSSAPAPVINQISTTSSSGFSASVGGQNPSTGASSADRTQGNIGCGGDTEPGQSSSQPSQDGQESVTERERIGIPTEPDSADSQAYPPAVVIYMVDPFTYTADEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQCLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIALPNRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKRLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length1082
PositionMiddle
OrganismLeptonychotes weddellii (Weddell seal) (Otaria weddellii)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Phocidae> Leptonychotes.
Aromaticity0.07
Grand average of hydropathy-0.267
Instability index61.01
Isoelectric point5.95
Molecular weight118173.70
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20573
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     114.80|      26|      28|     414|     439|       1
---------------------------------------------------------------------------
  414-  439 (44.20/19.01)	GNAGPLASNSGSAAPS.TGSAFNPTSN
  443-  469 (35.82/13.99)	GNPAASSSASGSSVPPvSSSAPAPVIN
  474-  499 (34.78/13.36)	TSSSGFSASVGGQNPS.TGASSADRTQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     117.56|      28|      28|     940|     967|       2
---------------------------------------------------------------------------
  940-  967 (48.75/31.63)	GSHFQHSRSQGERL...L....SREAPEELKQQPL
  970-  998 (42.04/26.15)	G.YFV.STAKAENLpqwF....WSSCPQAQNQCPL
 1003- 1029 (26.77/13.67)	SLHHHISVAQTDEL...LparnSQRVPHPL.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.60|      14|      28|     502|     517|       3
---------------------------------------------------------------------------
  502-  517 (24.38/19.68)	IGCGgdTEPGQSSSQ..P
  531-  546 (23.21/11.25)	IGIP..TEPDSADSQayP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.01|      26|      28|     229|     256|       4
---------------------------------------------------------------------------
  229-  256 (43.33/33.34)	KRSGKIPPKLHNHMVHR..VWKecILNRTQ
  258-  285 (42.69/25.46)	KRSQMSTPTLEEEPANNpaTWD..FVDPTQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     154.74|      29|      29|     726|     754|       5
---------------------------------------------------------------------------
  721-  749 (44.61/25.54)	ELLETC..IV..N.......I.ALPNRSRRSKVSARKIGLQ
  750-  779 (38.42/21.03)	KLWEWCigIV..Q.......MtSLPWRVVIGRLG..RLGHG
  780-  810 (39.35/21.71)	ELKDWS..ILlgE.......C.SLQTISKRLKDVCRMCGIS
  816-  851 (32.35/16.61)	SILSAC..LV..AmepqgsfV.VMPDAVTMGSVFGRSTALN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.75|      23|      26|     612|     637|       6
---------------------------------------------------------------------------
  615-  637 (45.47/36.33)	YIQCLKSM..AFSVYCQCR...RPLPTQ
  639-  666 (30.28/13.72)	HIKSLTGFgpAASIEMTLKnpeRPSPIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.71|      14|      30|     128|     141|       7
---------------------------------------------------------------------------
  128-  141 (25.18/14.97)	NDDFPVAVEVI.VGG
  155-  169 (21.53/11.74)	QNDIPVPQSVAgAGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.87|      10|      30|     891|     904|       8
---------------------------------------------------------------------------
  891-  904 (15.95/17.64)	SPNNDdmfvDLPFP
  922-  931 (20.92/10.08)	SPNSS....PVPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.29|      18|     341|       8|      26|      11
---------------------------------------------------------------------------
    8-   26 (30.23/22.72)	IGKWFVRPYEKDEKPvNKS
  351-  368 (36.06/22.66)	VSEWFNQPWSSEEND.NHS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20573 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPE
2) ITVGQQGLGSVKDPSNCGMPLTPPTSPEQAVIGESGGTQSAVSHLGSQDGGMITMHSPKRSGKIPPKL
3) KYQSPPAAAQGQATPGNAGPLASNSGSAAPSTGSAFNPTSNSSAGNPAASSSASGSSVPPVSSSAPAPVINQISTTSSSGFSASVGGQNPSTGASSADRTQGNIGCGGDTEPGQSSSQPSQDGQESVTERERIGIPTEPDSA
912
171
399
960
238
540










Molecular Recognition Features






MoRF SequenceStartStop




NANANA