<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20567

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDFLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPISRLLTDGIMRVGSTASKKLSEKLVAEWFSQAADGNNEAFSKLKLYAQVCRYDLGPYLASQPLDSSLLSQPNLVAPTSQSLITPPQMTSTGNANTPSATLASAASSTMTMTSGVTMSSSVATANSTLTTTSTSSSSSSNLNSGVSSNKLPSFPPFGSMNSSATGSMSTQASTVQNGQLGGQQSSALQTAGISGESSSLPTQPHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENKDESTNSSNVWTLGLLRCFLEMVQTLPPHIKSTVSVQIVPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALKSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKGSARRFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSSLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQMLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDAGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length904
PositionMiddle
OrganismLeptonychotes weddellii (Weddell seal) (Otaria weddellii)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Phocidae> Leptonychotes.
Aromaticity0.08
Grand average of hydropathy-0.194
Instability index51.29
Isoelectric point6.00
Molecular weight98801.06
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20567
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     210.33|      40|      43|     222|     261|       1
---------------------------------------------------------------------------
  193-  232 (49.43/22.16)	..LASQPldSSLLSQPNLVAPT........SQSLITPPQMTSTGNANTPS
  233-  272 (56.07/26.06)	ATLASAA..SSTMTMTSGVTMS........SSVATANSTLTTTSTSSSSS
  606-  637 (37.27/15.00)	.........SSLLSRRNL.QSL........SKRLKDMCRMCGISAADSPS
  638-  668 (37.46/15.11)	.ILSACL..VAMEPQGSFVIMP........DSV........STGSVFGRS
  669-  708 (30.09/10.78)	TTLNMQT..SQMLNTPQDTSCThilvfptsASVQVASATYTT........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     165.66|      51|     399|     379|     443|       2
---------------------------------------------------------------------------
  379-  434 (76.48/62.65)	ENKDESTnSSNVWTLGLLRCFLEMVQTL.PPHIKSTVSVQIVPcqYLLQPVKheDRQ
  451-  502 (89.18/41.30)	CRRPLPT.STNVKTLTGFGPGLAMETALkSPDRPECIRLYTPP..FILAPVK..DKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.68|      16|      22|     291|     306|       3
---------------------------------------------------------------------------
  291-  306 (28.50/14.91)	GSMNSSA..TGSMSTQAS
  314-  331 (23.18/10.86)	GGQQSSAlqTAGISGESS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.10|      27|      43|     717|     745|       6
---------------------------------------------------------------------------
  717-  745 (40.47/37.18)	PN.NDGADGMGIFDLLDTgDDLDpDIINIL
  762-  789 (44.63/29.29)	PHgGDAGKGQGTDRLLST.ESHD.EVTNIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.10|      14|      27|     562|     575|       7
---------------------------------------------------------------------------
  562-  575 (27.87/17.56)	GSARRFGLQKLWEW
  592-  605 (27.23/17.00)	GRLGRIGHGELKDW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20567 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GSPVHSPGSHYPHGGDAGKGQGTDRLLSTESH
2) TSGVTMSSSVATANSTLTTTSTSSSSSSNLNSGVSSNKLPSFPPFGSMNSSATGSMSTQASTVQNGQLGGQQSSALQTAGISGESSSLPTQPHPDVSESTMDRDKVGIPTDGD
3) VAPTSQSLITPPQMTSTGNANTPSATLASAASSTM
751
246
209
782
358
243










Molecular Recognition Features






MoRF SequenceStartStop




NANANA