<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20549

Description mediator of RNA polymerase II transcription subunit 23 isoform X1
SequenceMVQMETQLQSIFEDVVKTEIIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWSLTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQTLNIAQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRVPLPGTSCLASASITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRERPHLKRKLVHAIIGSLKDNRPQGWCLSDTYLKCGMNAREENPWVPDDSYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGEDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTTESEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSAHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAVPAQAMSSGSPAPQSNQVPGSLPVTQ
Length1377
PositionTail
OrganismLeptonychotes weddellii (Weddell seal) (Otaria weddellii)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Phocidae> Leptonychotes.
Aromaticity0.10
Grand average of hydropathy-0.008
Instability index46.15
Isoelectric point6.93
Molecular weight157310.11
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20549
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.64|      26|      89|    1074|    1101|       1
---------------------------------------------------------------------------
 1074- 1101 (47.32/33.13)	DSYYCRLIGRLVDTMAgkSPGPFPNCDW
 1167- 1192 (47.32/26.96)	EPYWIVLHDRIVSVIS..SPSLTTESEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.14|      10|      30|     348|     357|       2
---------------------------------------------------------------------------
  348-  357 (18.69/ 9.34)	IFFVLFQFAS
  381-  390 (19.45/10.01)	LMWVLLQFIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     151.91|      47|     619|     496|     544|       3
---------------------------------------------------------------------------
  496-  544 (73.48/56.87)	CFTLPMGALVETIYGNGIMRVPLPGTSCLASASITPLpMNLLdSLTVHA
 1118- 1164 (78.42/50.55)	CVELMALAVSGEDVGNALLNVVLKSQPLVPRENITAW.MNAI.GLIITA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.73|      28|      43|     610|     638|       4
---------------------------------------------------------------------------
  610-  638 (48.25/30.00)	LHTLLEMFSYRM......HHIQPHYrVQLLSHLHT
  650-  683 (42.48/21.91)	LHLCVESTALRLitalgsSEVQPQF.TRFLSDPKT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     166.74|      35|     791|     177|     217|       5
---------------------------------------------------------------------------
  181-  217 (58.73/46.21)	LPAYFAVTEIR.............KLYPEGKLPHWLLGNL..VSDFVDtfRP
  934-  955 (22.54/ 6.73)	..........H.............KKYPE.KLYFEGLAEQ..VDPPVQ....
  961- 1010 (43.04/19.01)	LPIYFGNVCLRflpvfdivihrflELLPVSKSLETLLDHLggLYKFHD..RP
 1019- 1048 (42.44/21.43)	..HYYEMHLRE.............RPHLKRKLVHAIIGSL..KDN.....RP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.05|      10|      28|     138|     147|       6
---------------------------------------------------------------------------
  138-  147 (15.61/ 9.27)	RDLLKVILEK
  167-  176 (16.44/10.15)	REVIAYILER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     160.29|      51|     717|      25|      92|       7
---------------------------------------------------------------------------
   32-   92 (83.44/87.79)	TPEDEKTKLISCL.GAFRQF........................WGGLSQESHeqciqwIVKFIHGQHSPKrisfLYDCL..AMAVET
  732-  809 (76.85/42.45)	TPHNWASHTLSCFpGPLQAFfkqnnvpqesrfnlkknveeeyrkWKSMTNEND......IITHFSMQGSPP....LFLCLlwKMLLET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.96|      12|      43|     240|     251|       8
---------------------------------------------------------------------------
  240-  251 (23.75/15.45)	ICNSWKLDPATL
  286-  297 (22.22/13.92)	VCNMLGLNKQTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     162.66|      51|     261|     549|     603|      10
---------------------------------------------------------------------------
  549-  603 (78.75/65.25)	IHSIATRVIKLAHAKSSValapALVETYSRLLVYMEIESLG...IKGFISQLLPTVFK
  812-  865 (83.91/59.18)	INQIGYRVLERIGARALV....AHVRTFADFLVYEFSTSAGgqqLNKCIEILNDMVWK
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20549 with Med23 domain of Kingdom Metazoa
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