<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20541

Description cyclin-dependent kinase 19 isoform X2
SequenceMDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDEPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGAGAAGAGLQHSQDAGLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSAQYHPSHQGHRY
Length458
PositionKinase
OrganismLeptonychotes weddellii (Weddell seal) (Otaria weddellii)
KingdomMetazoa
Lineage
Aromaticity0.08
Grand average of hydropathy-0.784
Instability index54.74
Isoelectric point8.55
Molecular weight51738.71
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20541
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     303.18|      95|     151|      12|     118|       1
---------------------------------------------------------------------------
   12-  118 (144.38/113.16)	ERERVE.DLFEYeGCKVGR.GTYGHVYKARRKDGKDEKEYALKQIEG..TGISMSACREIALLRelKHPNVIALQKVFlshsdRKVwllfDYAEHDLWHIIKFHRASKANK
  165-  263 (158.80/94.34)	ERGRVKiDIWAI.GCIFAElLTSEPIFHCRQEDIKTSNPFHHDQLDRifSVMGFPADKDWEDIR..KMPEYPTLQKDF.....RRT....TYANSSLIKYMEKHKVKPDSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.28|      22|      33|     367|     388|       2
---------------------------------------------------------------------------
  346-  362 (26.04/10.92)	...AAPPQAPPPQQNSTQT..N
  367-  388 (37.32/18.53)	GAGAGAGAAGAGLQHSQDAGLN
  402-  422 (38.92/19.61)	GANSGGPVMPSDYQHSS.SRLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.35|      10|      17|     423|     432|       3
---------------------------------------------------------------------------
  423-  432 (18.90/ 9.99)	YQSSVQGSSQ
  439-  448 (18.45/ 9.61)	YSSSSQQSAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.52|      16|      17|     275|     290|       4
---------------------------------------------------------------------------
  275-  290 (28.65/17.81)	DPTKRITSEQALQDPY
  294-  309 (30.88/19.73)	DPLPTLDVFAGCQIPY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20541 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YPKREFLNEDEPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGAGAAGAGLQHSQDAGLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSAQYHPSHQGHRY
309
458










Molecular Recognition Features






MoRF SequenceStartStop




1) NKKPRLG
2) QYHPSHQGHRY
3) TLGYS
393
448
436
399
458
440