<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20531

Description mediator of RNA polymerase II transcription subunit 12-like protein-like
SequenceMKHKNLHADKDAVRPSLSTSETDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGPKARKNKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMLHHPQSTLWGYNLMGQPQQPGFFLQNQSLTPGGSRLDPTGSFVPTNTKQALSNMLQRRSGAMMQPPPLHAITSQQQLIQMKLLQQQQQQRLLRQAQARPFQQLYPNFPPFSAQNHFAVLCSSQGQPVYFNSPKKDNMFSLHLAETNLEECNWLKATDNHMDIDDIKEEDF
Length773
PositionKinase
OrganismLeptonychotes weddellii (Weddell seal) (Otaria weddellii)
KingdomMetazoa
Lineage
Aromaticity0.07
Grand average of hydropathy-0.531
Instability index55.95
Isoelectric point6.66
Molecular weight87520.57
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20531
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.17|      16|      27|     171|     187|       1
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  171-  187 (22.97/21.19)	LLLKSSSLAGSYtTGLC
  201-  216 (29.21/21.34)	LILNPDQTAQVF.EGLC
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.26|      20|      25|     695|     719|       2
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  695-  719 (28.78/30.51)	LRQAQARPfqqLYPNFPpfSAQNHF
  722-  741 (39.48/22.72)	LCSSQGQP...VYFNSP..KKDNMF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.96|      25|      25|     636|     660|       3
---------------------------------------------------------------------------
  636-  660 (42.59/27.04)	GSRLDPTGSFVPTNTKQALS.NMLQR
  663-  688 (39.37/24.39)	GAMMQPPPLHAITSQQQLIQmKLLQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.82|      27|     100|     506|     532|       4
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  506-  532 (53.48/32.52)	QHHLLLYHTHPMPKPRSYYLEPLPLPP
  608-  634 (51.34/30.91)	QSTLWGYNLMGQPQQPGFFLQNQSLTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     173.45|      59|     156|     226|     293|       5
---------------------------------------------------------------------------
  226-  293 (89.06/88.79)	SECS..SP...ERCILAYLyDLyvsCSHLRSKFGDLFSMSLLSQQPFLSL......VLTClkgqdEQREGLLTSLQNQV
  382-  451 (84.39/58.81)	SDLSnaSPggsEENKRAYM.NL...VKKLKKELGDKRSESIDKVRQLLPLpkqtcdVITC.....EPMGSLIDTKGNKI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     188.98|      64|     225|      78|     152|       6
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   78-  152 (91.28/87.17)	KARKNKQEAFPtletvfTKLQLL.SYFDQHQVTSQISNN...VLEQITSfaSGT.SYHLPlAHHIQLIFDLMepALNING
  310-  378 (97.69/62.78)	KARQMMHEALQ......LRLNLVgGMFDTVQRSTQWTTDwalLLLQIIT..SGTvDMHTN.NELFTTVLDML..GVLING
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20531 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PGFFLQNQSLTPGGSRLDPTGSFVPTNTKQALSNMLQRRSGAMMQPPPLHA
2) RSYYLEPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMLH
623
521
673
605










Molecular Recognition Features






MoRF SequenceStartStop




1) RSYYLEPLPLP
521
531