<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20499

Description mediator of RNA polymerase II transcription subunit 26
SequenceMTAAPASPQQIRDRLLQAIDPQSNIRNMVAVLEVISSLEKYPITKEALEETRLGKLINDVRKKTKNEELAKRAKKLLRSWQKLIEPVHQNEAALRGLAGSTGSANGGAHNCRPDGGAAGAPKSIHELKNRNDIQRLPGQRLDRLGSRKRRGDQRDLGHPGPPPKVSKASHDSLVPNSSPLPTNGIGGSPESFPGALDGSGHAGPEGSRLEHGESDKHGGKIPVNAVRPHTSSPGLGKPPGPCLQTKAAVLQQLDRVGETPGPPHPKGPPRCSFSPRNSRHEGSFARQRSPYTPKGSVPSPSPRPQALDATQVPSPLPLAQPSTPPVRRLELLPSAESPVRWLEQPEGHQRLAGQGCKGGLPPAEPLLPRAGFSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPVRADSPVHTEQPRTELDKPEAKASVQSPFEQTNWKELSRNEIIQSYLSRQSSLLSSSGAQTPGAHHFMSEYLKQEESTRRGARKPHVLVPHSAPTDLPGLNREVTQDDLDRIQAHQWPGVNGCQDTQGNWYDWTQCISLDPHGDDGRLNILPYVCLD
Length599
PositionUnknown
OrganismOdobenus rosmarus divergens (Pacific walrus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Odobenidae> Odobenus.
Aromaticity0.04
Grand average of hydropathy-0.879
Instability index57.88
Isoelectric point9.53
Molecular weight65100.32
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20499
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     433.06|      98|      98|     102|     199|       1
---------------------------------------------------------------------------
   97-  185 (144.02/51.33)	..........LAGS.....tGS........ANGG...AHNCRPDGGAAGAPKSIHELKNR...NDIQ.RL..............PG..........QRLDRLGSRKRRGDQRDLGHPGPPPKVS....KASHD.SLVPNSSP.LPTNGI
  186-  296 (108.50/37.05)	GGSPESFPGALDGSghagpeGSrlehgesdKHGGkipVNAVRPHTSSPGLGKP...............................PGpclqtkaavlQQLDRVG..ETPGP....PHPKGPPRCSfsprNSRHEgSFARQRSP.YTPKGS
  297-  372 (86.53/28.21)	VPSPSPRPQALDAT........................................................qvpsplplaqpstpPV..........RRLELLPSAE..SPVRWLEQPEGHQRLA....GQGCK.GGLPPAEPlLPRAGF
  373-  452 (94.02/31.23)	..SPDSSKA..................................DSDAASSGGSDSKKKKRyrpRDYTvNL..............DG..........Q.VAEAGVKPVRLKERKLTFDPMTRQIK....PLTQK.EPVRADSP.VHTE..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.57|      15|      22|     488|     504|       2
---------------------------------------------------------------------------
  488-  504 (21.68/18.76)	YLSRQSSllSSSGAQTP
  513-  527 (26.89/16.42)	YLKQEES..TRRGARKP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20499 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HQNEAALRGLAGSTGSANGGAHNCRPDGGAAGAPKSIHELKNRNDIQRLPGQRLDRLGSRKRRGDQRDLGHPGPPPKVSKASHDSLVPNSSPLPTNGIGGSPESFPGALDGSGHAGPEGSRLEHGESDKHGGKIPVNAVRPHTSSPGLGKPPGPCLQTKAAVLQQLDRVGETPGPPHPKGPPRCSFSPRNSRHEGSFARQRSPYTPKGSVPSPSPRPQALDATQVPSPLPLAQPSTPPVRRLELLPSAESPVRWLEQPEGHQRLAGQGCKGGLPPAEPLLPRAGFSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPVRADSPVHTEQPRTELDKPEAKASVQSPFEQTNW
2) QSSLLSSSGAQTPGAHHFMSEYLKQEESTRRGARKPHVLVPHSAPTDLPGLNREVTQDDLDRIQAHQWP
88
492
476
560










Molecular Recognition Features






MoRF SequenceStartStop




1) IRDRLL
2) RLKERKL
3) SKKKKRYRPRDYTVNLDGQVA
4) VRRLELLP
11
419
391
326
16
425
411
333