<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20492

Description mediator of RNA polymerase II transcription subunit 14
SequenceMAPVQLENHQLVPPGGGGGASGGPASAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNAVEREDTPLMALLLQQFKENIQDLVFRTKPGKQPRTGPKRKLSDDPCPVEPKKTKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQMEGDGFSHAIRLLKIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGSSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRMPGMSPANPSLHSPVPDASHSPRAGTSSQTLPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
Length1454
PositionTail
OrganismOdobenus rosmarus divergens (Pacific walrus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Odobenidae> Odobenus.
Aromaticity0.07
Grand average of hydropathy-0.188
Instability index51.72
Isoelectric point8.97
Molecular weight160733.93
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20492
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.03|      24|      30|    1326|    1351|       1
---------------------------------------------------------------------------
 1326- 1351 (43.68/28.24)	PdqATQLKWNVQFC..LTIPPSAPPIAP
 1355- 1380 (39.36/19.41)	P..AVVLKSKMLFFlqLTQKTSVPPQEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      93.37|      24|      30|    1001|    1025|       2
---------------------------------------------------------------------------
   25-   43 (28.33/ 8.41)	ASAP.......APPP.....PGAAVAAAAAA
 1001- 1020 (33.81/11.31)	...........QPPPQQQPFPKQPGSSGAYP
 1057- 1087 (31.23/ 9.67)	LRAPspasfvpTPPPSSHGISIGPGASFASP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.64|      30|      32|     246|     275|       3
---------------------------------------------------------------------------
  246-  275 (48.89/33.28)	RLLKLEILVEDKETGDGRALVH....SMQINFIH
  276-  309 (45.75/30.65)	QLVQSRLFADEKPLQDMYNCLHsfclSLQLEVLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     157.03|      35|      67|    1022|    1056|       4
---------------------------------------------------------------------------
 1022- 1054 (56.97/28.14)	..............TSP.....PT...SY......................HSTVNQSPSMMHTQ.SPGN..LHA.ASSPS
 1055- 1111 (28.67/10.25)	GA...............lrapsPA...SFvptpppsshgisigpgasfaspHGTLD..PSSPYTMvSPSG...RA.GNWPG
 1112- 1142 (34.44/13.89)	...............SP.....QV...SG......................PSPATRMPGM.....SPANpsLHSpVPDAS
 1143- 1190 (36.95/15.48)	HSpragtssqtlptNMP.....PPrklPQ......................RSWAASIPTIL.TH.SALN..ILL.LPSP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     210.80|      66|     393|     447|     522|       5
---------------------------------------------------------------------------
  447-  522 (108.43/102.46)	GNSEC....LHIFVDLHS...GMFQLMLYGLD.QATLDDMEKsvnddmkriIPWIQQLKFWLGQQRCKQSIKHLPTiSSETLQL
  843-  916 (102.37/73.40)	GCSNChntiLHQLQEMFNktpNVVQLLQVLFDtQAPLNAINK.........LPTVPMLGLTQRTNTAYQCFSILPQ.SSTHIRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.27|      32|      32|      66|      97|       7
---------------------------------------------------------------------------
   66-   97 (51.36/42.23)	LMVLTDLLPRKSDVERKIEIVQFASRTRQLFV
   99-  130 (52.92/43.78)	LLALVKWANNAGKVEKCAMISSFLDQQAILFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.33|      10|      25|    1402|    1411|      12
---------------------------------------------------------------------------
 1402- 1411 (17.56/ 8.58)	PRQQNSSVAA
 1428- 1437 (19.77/10.55)	PRQGECTIFA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.75|      12|      32|     359|     370|      14
---------------------------------------------------------------------------
  359-  370 (20.47/13.79)	IKIDENDVSKPL
  390-  401 (20.28/13.58)	MKIDHLSIEKLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.21|      40|     127|     595|     634|      15
---------------------------------------------------------------------------
  595-  634 (74.00/42.80)	IQDLVFRTKP..GKQPRT.GPKRK..LSDDPCPVEPKKTKRSGEM
  721-  765 (57.20/31.34)	VAELVFANCPlnGTSTREqGPSRHvyLTYENLLSEPVGGRKVVEM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.10|      11|      32|     135|     145|      17
---------------------------------------------------------------------------
  135-  145 (16.90/ 9.80)	RLASLARDALV
  168-  178 (20.20/13.32)	RLPTCIRDKII
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.28|      33|      40|    1221|    1260|      20
---------------------------------------------------------------------------
 1221- 1258 (50.65/46.39)	QRIIQQETLQLINSNEPGVI..MFKTdalkcRVALSP.KTN
 1262- 1297 (50.63/27.58)	QLKVTPENAGQWKPDELQVLekFFET.....RVAGPPfKAN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20492 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGSSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRMPGMSPANPSLHSPVPDASHSPRAGTSSQTLPTNMPPPRKLPQRSWA
970
1170










Molecular Recognition Features






MoRF SequenceStartStop




NANANA