<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20486

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEELKEEEELGYNDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVAGAGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAVIGESGGTQSAVSHLGSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPANNPATWEFVDPTQRVSCSCSRHKLLKRCAVGPNRPPAISQPGFSAGPSSSSSLPPPASKHKTTERPEKGDKLQKRPLIPFHHRPSVADEFCMEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGVRPSNPESSDKWWHSYRLPPVDDTEFRPPELQGDRCDAKMEVNSESTALQRLLAQPNKRFKIWQEKPPQMQPLHFLDPLPLAQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPAVGAEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTQLTEFRMEVEDGLGSPKPEEVKDFSYVHRVPTFQPFVGSSMFAPLKMLPSQCLLPLKIPDTCLFRPSWAIPPKIEQLPMPPAAIFNRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQTTFLPQMEGARKSPEPPISLLLLLQNQHTQPFASLSFLDYISSNSRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWSSEENDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQSPPAAAQGQATPGNAGPLASNSGSAAPSTGSAFNPTSNSSSGNPTASSSASGSSVPPVSSSAPAPVINQISTTSSSGFSASVGGQNPSTGASSADRTQGNIGCGGDTEPGQSSSQPSQDGQESVTERERIGIPTEPDSADSQAYPPAVVIYMVDPFTYTADEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIALPNRSRRSKISARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKRLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2210
PositionMiddle
OrganismOdobenus rosmarus divergens (Pacific walrus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Odobenidae> Odobenus.
Aromaticity0.07
Grand average of hydropathy-0.384
Instability index57.58
Isoelectric point5.65
Molecular weight242814.06
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20486
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.93|      26|      28|    2068|    2095|       1
---------------------------------------------------------------------------
 2068- 2095 (37.05/31.48)	GsHFQhSRSQGERL...LSREAPEELKQQPL
 2098- 2126 (44.88/27.40)	G.YFV.STAKAENLpqwFWSSCPQAQNQCPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.06|      24|      28|    1009|    1035|       2
---------------------------------------------------------------------------
 1009- 1035 (38.47/25.77)	PdylNTPQMNTPVTLNSAAPASNSGAG
 1040- 1063 (44.60/22.51)	P...ATPRFSVPTPRTPRTPRTPRGGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     507.61|     120|     711|     802|     925|       3
---------------------------------------------------------------------------
  318-  364 (39.97/10.76)	...........................................................................PSNCGMPlT....PPTSP.EQA...VIGESGGTQS.AVSHLGSQDGGMITMHSPKR................
  509-  594 (100.22/39.74)	....LAGIDSSLEVSSSrkyDKQMAV.PSRNTSKQMNLNPMDSP....HSPISPL...............PPTLSPQPRGQE.TesldPPSVPVNPAL.....YGNGLELQQLSTL...............................
  802-  925 (190.48/93.83)	LAPSLHDLDNIFDNSDD...DELGAVSPALRSSKMPAVGAEDRPLGKDGRAAVPY...............PPTVADLQRMFP.T....PPSLEQHPAFsPVMNYKDGISSETVTALGMMESPMVSMVSTQLTEfrMEVEDGlGSPKP
 1509- 1638 (176.94/77.22)	LAPYLATLQ..LDSSLL...IPPKYQSPP.AAAQGQATPGNAGPLASNSGSAAP.stgsafnptsnsssgNPTASSSASGSS.V....PPVSSSAPA..PVINQISTTSSSGFSASVGGQNPSTGASSADRTQ..GNIGCG.GDTEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.13|      20|      28|    1131|    1157|       4
---------------------------------------------------------------------------
 1131- 1150 (40.30/32.71)	CICACNMNIK.GADVGLYIPD
 1161- 1181 (33.83/12.92)	CGFSAIMNRKlGYNSGLFLED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.64|      15|      28|    1849|    1875|       5
---------------------------------------------------------------------------
 1849- 1863 (27.99/ 8.50)	ELLETC..IVNI.ALPNR
 1878- 1895 (24.65/27.24)	KLWEWCigIVQMtSLPWR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.27|      32|    1265|     156|     189|       6
---------------------------------------------------------------------------
  156-  189 (52.23/43.55)	PVNKSeHLSCAFTFFlHGESNVCTSVEIAQHQPI
 1424- 1455 (59.04/39.42)	PENEA.LLEGAKTFF.RDLSAVYEMCRLGQHKPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.07|      18|      28|    2019|    2041|       7
---------------------------------------------------------------------------
 2019- 2041 (24.82/27.61)	SPNNDdmfvDLPFPDDmDNDIGI
 2050- 2067 (34.25/18.64)	SPNSS....PVPSPGS.PSGIGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.14|      23|      26|    1740|    1765|       8
---------------------------------------------------------------------------
 1740- 1765 (38.99/31.79)	QvfyIQYLKSM..AFSVYCQCR...RPLPTQ
 1767- 1794 (30.15/15.74)	H...IKSLTGFgpAASIEMTLKnpeRPSPIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.95|      25|      27|      60|      84|      10
---------------------------------------------------------------------------
   60-   84 (48.05/33.76)	FIRCLQANLLCVWRRDVKPDCKELW
   86-  110 (47.90/33.62)	FWWGDEPNLVGVIHHELQVVEEGLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     172.52|      52|     711|     639|     697|      11
---------------------------------------------------------------------------
  379-  431 (80.97/38.88)	RVWKEcilNRTQSKRSQMSTPTLEEEPANNPATW.EFVDP.TQRV.SCSCSRHKLL
  639-  672 (43.42/17.42)	.....................PVDDTEFRPPELQGDRCDA.KMEVNSESTALQRLL
  680-  697 (18.07/11.90)	KIWQE...KPPQMQPLHFLDP...................................
 1665- 1695 (30.06/ 8.88)	....................PDSADSQAYPPAVVIYMVDPfTYTADEDSTS.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.49|      19|      21|     963|     981|      13
---------------------------------------------------------------------------
  963-  981 (35.82/18.44)	LKIPDTCLF.RPSWAIPPKI
  984- 1003 (28.67/13.15)	LPMPPAAIFnRDGYNNVPSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.55|      11|      17|    1231|    1241|      18
---------------------------------------------------------------------------
 1231- 1241 (20.74/ 8.68)	QHTQPFASLSF
 1250- 1260 (22.81/10.23)	RQTLPCVSWSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.41|      14|      17|     225|     240|      19
---------------------------------------------------------------------------
  225-  238 (24.00/21.32)	YKMSDPATRKLIEE
  243-  256 (23.41/10.39)	YPMVLKKKEELKEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.42|      18|      21|    1697|    1716|      20
---------------------------------------------------------------------------
 1697- 1716 (30.77/23.60)	NFWLLSLMRC.YteMLDNLPE
 1720- 1738 (29.64/16.22)	NSFILQIVPCqY..MLQTMKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.55|      18|      26|    1339|    1356|      23
---------------------------------------------------------------------------
 1339- 1356 (33.04/21.25)	KKRTGRTWENIQHVQGPL
 1362- 1379 (32.51/20.76)	HKMAGRGTYGSEESPEPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20486 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APSLHDLDNIFDNSDDDELGAVSPALRSSKMPAVGAEDRPLGKDGRAAVP
2) CAVGPNRPPAISQPGFSAGPSSSSSLPPPASKHKTTERPEKGDKLQKRPLIPFHHRPSVADEFCMEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLEL
3) ECILNRTQSKRSQMSTPTLEEEPANNPATWEFV
4) GILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPE
5) GTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTD
6) ITVGQQGLGSVKDPSNCGMPLTPPTSPEQAVIGESGGTQSAVSHLGSQDGGMITMHSPKRSGKIPPKLH
7) KYQSPPAAAQGQATPGNAGPLASNSGSAAPSTGSAFNPTSNSSSGNPTASSSASGSSVPPVSSSAPAPVINQISTTSSSGFSASVGGQNPSTGASSADRTQGNIGCGGDTEPGQSSSQPSQDGQESVTERERIGIPTEPDSA
8) SVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQ
803
434
383
2040
735
305
1527
1002
852
588
415
2088
801
373
1668
1100










Molecular Recognition Features






MoRF SequenceStartStop




1) KRFKIW
677
682