<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20485

Description mediator of RNA polymerase II transcription subunit 12 isoform X1
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVIDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVMSAQSTSTLPATPAPQPPTSSAPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDSERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPYRLLDSEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDNQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGERQSDSLEKVLQLLPLPKPTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHTNPGSISHLSYRQGSIGLYTQNQPLPAGGPRMDSYRPVRLPMQKLPTRPPYPGVLPTTMTGVMGLEPSYKTSVYRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLASTQRFSQQTLQQAPMIGAMTPLGAQGVQAGGVRSASILPEQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQQQQILRARRPCPQQQQQQQQQQQQQQQQQQAHQQQQQQQQAAPPQAQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2179
PositionKinase
OrganismOdobenus rosmarus divergens (Pacific walrus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Odobenidae> Odobenus.
Aromaticity0.07
Grand average of hydropathy-0.492
Instability index57.63
Isoelectric point6.80
Molecular weight242909.84
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20485
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     184.82|      16|      16|    2051|    2066|       1
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 2050- 2065 (34.94/13.90)	EQQQQQQQQQQQQQQQ
 2066- 2081 (33.45/12.99)	QQQQQQQQQQYHIRQQ
 2102- 2117 (34.24/13.47)	QQQQQQQQQQQQQQAH
 2118- 2131 (26.04/ 8.48)	QQQQQQQQ..AAPPQA
 2132- 2147 (29.51/10.59)	QPQSQPQFQRQGLQQT
 2148- 2163 (26.63/ 8.84)	QQQQQTAALVRQLQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.20|      25|      46|     346|     370|       2
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  346-  370 (47.16/28.51)	PFSDLLMCPQHRPLVFGLSCILQTI
  394-  418 (46.04/27.63)	PLDHLPIAPSNLPMPEGNSAFTQQV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     113.91|      18|      18|    1734|    1751|       3
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  683-  699 (26.05/10.09)	PDFSLFSP....TMPCEGKGS
 1734- 1751 (33.32/15.28)	PRAYYLEP...LPLPPEDEEP
 1752- 1772 (26.94/10.72)	PAPTLLEPekkAPEPPKTDKP
 1795- 1811 (27.59/11.19)	P.ATKTED...YGMGPGRSGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     212.26|      41|      56|    1815|    1855|       4
---------------------------------------------------------------------------
 1815- 1853 (69.76/34.54)	.............TVP..........PDL...........LH.HTNPGSIS...HLSYRQG......SIGLYTQNQPLPAGGP
 1854- 1908 (43.99/18.87)	RM.....dsyrpvRLPmqklptrppyPGV...........LP.TTMTGVMG..lEPSYK.T......SV..YRQQQPAVPQGQ
 1909- 1960 (32.17/11.68)	RL.......................rQQLqqsqgmlgqssVH.QMTPSSSY...GLQTSQGytpyvsHVGL..QQHTGPAG..
 1963- 2007 (38.64/15.62)	..............VP..........PSY....ssqpyqsTHpSTNPTLVDptrHLQQRPS........G.YVHQQA.PTYGH
 2008- 2042 (27.71/ 8.97)	GLastqrfsqqtlQQA..........PMI..................GAMT...PLG.................AQGVQAGGV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     454.98|     108|     231|     217|     336|       5
---------------------------------------------------------------------------
  217-  327 (179.47/128.16)	GSTIGPLPHDVEV....AIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLL..RYSGE...FVQSAYLSRRLAYF......CTRRLAlqlDGVSSHS......SHVMSAQSTS
  451-  558 (137.70/88.96)	GFTIGRVLHTLEVldshSFERSDFSNSL......DSLCNRIFGLGPSKDGHE.ISSDDDAVVSLLCEWAVscKRSGRhraMVVAKLLEKRQAEI......EAERC.....GESEAA......DEKGSIASGS
  565-  673 (137.81/101.16)	.....PIFQDV.......LLQF.LDTQAPMLTDPRSESERVEFFNLVLLFCELIR..HDVFSHNMYTCTL..ISRGD...LAFGAPGPRPPSPFddpaddSERKEA...EGSSSSKledpglSESMDIDPSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.35|      19|      22|    1652|    1672|       7
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 1652- 1672 (24.97/27.85)	EPQGSLIDTKgNKIAGFDsIF
 1673- 1691 (34.38/24.68)	KKEGLQVSTK.QKISPWD.LF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.44|      14|      15|     862|     876|       9
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  862-  876 (22.19/20.43)	LgMSYHLPLVQHVQF
  880-  893 (24.25/15.79)	L.MEYSLSISGLIDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.14|      13|      16|    1028|    1040|      11
---------------------------------------------------------------------------
 1028- 1040 (25.11/15.47)	ENPAA.HTFTYTGL
 1046- 1059 (21.03/11.73)	ENPANrYSFVCNAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.70|      14|      23|    1561|    1574|      17
---------------------------------------------------------------------------
 1561- 1574 (24.50/19.01)	LLEIIISGTV..DMQS
 1585- 1600 (20.20/14.14)	MLSVLINGTLaaDMSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.56|      33|     200|    1074|    1106|      18
---------------------------------------------------------------------------
 1074- 1106 (61.57/38.62)	DIAILCAELTGYCKSL.....SAEWLG..VLKALCCSSNN
 1268- 1307 (49.98/29.96)	NISVETASLDVYAKYVlrsicQQEWVGerCLKSLCEDSND
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20485 with Med12 domain of Kingdom Metazoa
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