<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20484

Description mediator of RNA polymerase II transcription subunit 12 isoform X5
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVIDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVMSAQSTSTLPATPAPQPPTSSAPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDSERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPYRLLDSEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDNQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGERQSDSLEKVLQLLPLPKPTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHTNPGSISHLSYRQGSIGLYTQNQPLPAGGPRMDSYRPVRLPMQKLPTRPPYPGVLPTTMTGVMGLEPSYKTSVYRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLASTQRFSQQTLQQAPMIGAMTPLGAQGVQAGGVRSASILPEQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQQQQILRQQQQQQQQQQQQQQQQQAHQQQQQQQQAAPPQAQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2172
PositionKinase
OrganismOdobenus rosmarus divergens (Pacific walrus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Odobenidae> Odobenus.
Aromaticity0.07
Grand average of hydropathy-0.488
Instability index57.29
Isoelectric point6.70
Molecular weight242100.89
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20484
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     190.37|      15|      15|    2051|    2065|       1
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 1899- 1916 (24.07/ 7.86)	QQQ.PavpQGQRL..RQQ...LQQ
 2051- 2062 (22.28/ 6.67)	....Q...QQQQQ..QQQ...QQQ
 2063- 2081 (24.64/ 8.23)	QQQqQ...QQQQQ..QQQyhiRQQ
 2082- 2096 (31.50/12.78)	QQQ.Q...QQQIL..RQQ...QQQ
 2097- 2111 (33.43/14.05)	QQQ.Q...QQQQQ..QQQ...AHQ
 2112- 2126 (29.63/11.54)	QQQ.Q...QQQAA..PPQ...AQP
 2127- 2143 (24.82/ 8.35)	QSQ.P...QFQRQglQQT...QQQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.20|      25|      46|     346|     370|       2
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  346-  370 (47.16/28.15)	PFSDLLMCPQHRPLVFGLSCILQTI
  394-  418 (46.04/27.28)	PLDHLPIAPSNLPMPEGNSAFTQQV
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     319.48|     110|     232|     217|     336|       3
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  217-  287 (106.67/62.66)	....................................................................................................................................................................GSTIG.PLPHDVEV....AIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLL..RYSGE
  288-  331 (28.15/27.97)	FVQSAYLSRRLAYFCTRRLalqldGVSSHSSHVMSAQSTS.TLPA.....................................................................................................................................................................................................
  451-  520 (75.70/41.12)	.............................................tpapqpptssapstpfsdllmcpqhrplvfglscilqtillccpsalvwhysltdsriktgspldhlpiapsnlpmpegnsaftqqvraklreieqqikergqavevrwsfdkcqeataGFTIG.RVLHTLEVldshSFERSDFSNSL......DSLCNRIFGLGPSKDGHE.ISSDDDAVVSLLCEWAVscKRSGR
  524-  606 (108.97/67.04)	MVVAKLLEKRQAEIEAERC.....GESEAADEKGSIASGSlSAPS............................................................................................................................aPIFQDV.......LLQF.LDTQAPMLTDPRSESERVEFFNLVLLFCELIR......................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     118.31|      20|      20|    1734|    1753|       4
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 1734- 1753 (38.20/18.24)	PRAYYLEPLPLPPEDEEPPA
 1795- 1813 (29.97/12.51)	P.ATKTEDYGMGPGRSGPYG
 1838- 1854 (25.81/ 9.61)	SIGLYTQNQPLPAGG...PR
 1855- 1873 (24.33/ 8.57)	MDSYRPVRLPMQKLPTRPP.
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.35|      20|     231|    1754|    1780|       5
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  697-  717 (33.13/11.34)	KGSPSPEKPDvEKEVKPPPKE
 1761- 1780 (37.22/29.25)	KKAPEPPKTD.KPGAAPPSTE
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     102.69|      19|      20|    1945|    1963|       7
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 1945- 1963 (36.89/21.61)	P..YVSHVGLQQH..TGPAGTMV
 1964- 1984 (18.67/ 6.42)	PpsYSSQPYQSTHpsTNP..TLV
 1985- 1998 (19.66/ 7.24)	D..PTRH..LQQR....PSGYV.
 2013- 2030 (27.47/13.76)	Q..RFSQQTLQQ...APMIGAMT
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.98|      39|      57|    1040|    1080|       8
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 1040- 1080 (64.22/49.89)	LG..KSL...SENPANRYS.FVCNALMHvCVGHHDpDRVNDIAILCA
 1094- 1138 (53.77/32.47)	LGvlKALccsSNNGTCGFNdLLCNVDVS.DLSFHD.SLATFVAILIA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.88|      21|     180|     623|     643|      11
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  623-  643 (43.17/21.75)	GDLAF..GAPGPR....PPSPFDDPAD
  803-  829 (29.71/12.60)	GDLTFlgGEDGQKrrrnRPEAFPTAED
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.70|      14|      23|    1561|    1574|      12
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 1561- 1574 (24.50/19.79)	LLEIIISGTV..DMQS
 1585- 1600 (20.20/14.71)	MLSVLINGTLaaDMSS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     328.12|     109|     200|    1234|    1357|      13
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 1234- 1355 (169.56/124.63)	AELKGSGFTVTggteELPEEEGGGG..SGGRRQGGRNISVETASLDVYAK.YVLRSicqqewVGERCLKSLCEDSNDLQDpvlSSAQAQRLMQLIC.YPY..RLLDSEDGENPQRQRI.....KRILQNLDQW
 1395- 1514 (158.56/85.58)	AETGSSGSTAS....NMPSSSKTKPvlSSLERSGVWLVAPLIAKLPTSVQgHVLKA......AGEELEKGQHLGSSSRKE...RDRQKQKSMSLLSqQPFlsLVLTCLKGQDEQREGLltslySQVHQIVNNW
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.38|      13|      16|     864|     879|      14
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  864-  876 (24.86/23.24)	MSYHLPLVQHVQF
  881-  893 (22.52/ 9.18)	MEYSLSISGLIDF
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.54|      16|      16|     645|     660|      17
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  645-  660 (26.33/18.17)	SERKEAEGSSSSKLED
  664-  679 (28.21/20.14)	SESMDIDPSSSVLFED
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.05|      14|     184|     783|     800|      19
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  122-  135 (24.94/ 9.11)	GTKPLTQLAKKVPI
  787-  800 (25.11/ 9.27)	GTAETDQLAPIVPL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.58|      22|     161|    1525|    1547|      20
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 1525- 1547 (34.11/27.22)	PKQLMhEALKLRLNLVGGMFDTV
 1687- 1708 (45.47/30.78)	PWDLF.EGLKPSAPLSWGWFGTV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20484 with Med12 domain of Kingdom Metazoa
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