<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20462

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMMDFFFKGGLHQVSWFQYLPSESDPNLSDRSGKLNQRDVGAQLVLSAHLQLQKDGFLSTWGNSFVGPWDPSQGLHNPDEKIKLWLFIPGRHSSVPDKAKAALSKLRGLASGVWLAPGDSEEVAAALSQALRNSIERALIGLSYMRFGDVFSRYHSSSQGEVFRRGQPVLEFTFTATEEAVFVHVIISAKHVRALSNNDMETIVKRTSSQSSDRLPVIVSPHGMRGRLTGFCPGDLVKQLYFRFWLQNWMGPSLSGSSFSVQCDAFGTMEGSWHDNGIRSQHGYNSSGNSNSSSSTSSSSDRMTGDDLEADADSISCIKSGLTNADQMNIDGSKMGNKRTRAGMNESYGQASGADAYNSMEINNEQGGSQWDWDDDDRGVVMDIQALLSEFGDFGDFFENDALPFGEPPGTEESQTPTPMFSATDGGDVSSSPFTAMMDTTDPMILTGGFSSFESFNPPLPVIEESTSKNQEIVIKDNVSSGSMTYNPPPNNTEFEYLIKAEAMMTFAPEYGAVETPTTDLISSVIKTPYVPKSRTVESANSSTNSYVYSAVPPRRDATDDKSGPGTNSKDKYLLQSKKYYTHVENGTDKKDEKPSSRDIVVTSREDVTPSTLSGNTGLRSSTRNKLTGAESIVVSSKTGIANELECLMFQAFMCRIRHTLLTPASSLPAGLNRLSGNNNVLYQMHGESNVLQDNNITSKYDIKKKDIPIRIAGDLDSGLLDGSLNSPVGVWRTVGVTKGSKPMSNMEPFGSLPHNSFNEEGMLSYGQRQPLLELLDGMPLLFQQAASFVDVTLDADCGDGPYGWLAMQEQWRRGFSCGPSFAHAGCGGVLASCHSLDIAGVELADPLSAEVHASYAITLLQSDIKSALKSAFATFDGPLTVTDWCKGRNGGDGFPAESSASINDSSVEPMSPPQSAGGSTLSKGMDDMTDSEHQLIRPALLVVPIPAILVGYQDDWLKTSATSLQHWEKAPFEPYAMQKHMNYCVVCPDIDPLTTAAADFFQQLETVYETCKLGTHSAQNMGNQTSKDSGKWSSSGFVLLDCPQSMKIESNSASLVGSISDYFLSLSNGWDLTSFLKSLSKVLKALKLNSIFAPNSKEGNSTPCTVIYVVCPFPEPVAVLKTVVESCVAVGSAVFPSSDKERRSAMQNQVGKALSCSTAVDEASISNVVTISGFSIPKLVLQIVTVDAIFRVTSPSLNEPIILKEIAFTVYNKARRISRSSSDIIPSVSMPGRSQSHSGMMQMNSPMQGMWKDSVGPRMGQREGELDASMRGGTWDNSWQMSRPGGLGSDPNRSGEYSLHDELKYMFEPLFILAEPGSLERGLSPDSMKLLSDDGTSSDAGMGSQMDGSDDGFGSTHQKAPPSLHCCYGWTEDWRWLVCIWTDARGELLDSCTFPFGGISSRQDTKGLQFLFVQILQQGCQILQACSPDTSTARPRDFVITRIGSFFELECQEWQKALYSIGGSEVKKWSLQLRRSVPDGIPASSNGGPLQQQEMSIMQDRNHGKGSAYMKGGLGQPSGRKQQHLGGGGGGGHVAMDNSKGLLQWVQSITFVAVSVDHSLQLVYQADSSPGTTQGSGVMGQSCYVEGFTPVKSLGSASASYIFVPSPSMRFLPPNPLQLPTCLTSESPPLAHLLHSKGSAIPISTGFVVSKAVPSMRKDSRSNCKEEWPSVLSVGLCDYYGGNNNNGGNNEKMKNMGKSGVENNLILERVAAELHALSWMTVSPGYLERRSSLPFHCDMVLRLRRLLHFADKELSQISVKSEL
Length1763
PositionKinase
OrganismArtemisia annua (Sweet wormwood)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> campanulids> Asterales> Asteraceae> Asteroideae> Anthemideae> Artemisiinae> Artemisia.
Aromaticity0.08
Grand average of hydropathy-0.335
Instability index48.36
Isoelectric point5.35
Molecular weight191255.66
Publications
PubMed=29703587

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20462
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.91|      28|     130|     412|     445|       1
---------------------------------------------------------------------------
  416-  443 (52.77/25.89)	PTPMFSATDGGDVSSSPFTAMMDTTDPM
 1028- 1046 (28.96/ 8.67)	........DSGKWSSSGFV.LLDCPQSM
 1325- 1350 (40.19/13.09)	PDSMKLLSDDGTSSDAGMGSQMDGSD..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     251.69|      80|     565|     802|     933|       2
---------------------------------------------------------------------------
  804-  892 (128.68/131.24)	WLamqeqwRRGFSCGPSFA.HAGCGGVLASCHSLDIAGVELA..DPLSAEVHASYAItlLQSDIKSaLKSAFATFDGPL.TVTDWCK.....GRNGGD
  935- 1023 (123.00/47.92)	LI......RPALLVVPIPAiLVGYQDDWLKTSATSLQHWEKApfEPYAMQKHMNYCV..VCPDIDP.LTTAAADFFQQLeTVYETCKlgthsAQNMGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     240.93|      58|     567|     506|     563|       3
---------------------------------------------------------------------------
  506-  563 (99.57/58.89)	FAP..EYGAVETPTTDLISSVI.KTPY.VPKSRTVESANSSTNSYVY.SAVPPRRDATDDKSG
 1092- 1151 (80.62/46.15)	FAPnsKEGN.STPCT.VIYVVC.PFPEpVAVLKTVVESCVAVGSAVFpSSDKERRSAMQNQVG
 1564- 1610 (60.74/32.78)	......YQADSSPGTTQGSGVMgQSCY.VEGFTPVKSLGSASASYIF.VPSPSMR........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     124.24|      28|     567|     906|     933|       4
---------------------------------------------------------------------------
  906-  933 (50.06/23.04)	SVEPMSPPQ...SAGGSTLSKGMDDMTDSEH
 1476- 1503 (48.64/22.17)	SVPDGIPAS...SNGGPLQQQEMSIMQDRNH
 1514- 1538 (25.54/ 8.05)	LGQPSGRKQqhlGGGGGGGHVAMDN......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     148.96|      45|      88|     263|     311|       6
---------------------------------------------------------------------------
  263-  311 (71.60/48.30)	DAFGTMEGSWHDNGirSQHGYNSSGNS...NSSSSTSSSSDrmTGDDLEADA
  354-  401 (77.36/41.00)	DAYNSMEINNEQGG..SQWDWDDDDRGvvmDIQALLSEFGD..FGDFFENDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     243.30|      57|     565|     663|     727|       8
---------------------------------------------------------------------------
  663-  719 (95.03/41.56)	PASSLPAGLNRLSGNNNVLYQMHGESNVLQDNNITSKYDIKKKDIPIRI...AGDLDSGL
 1226- 1279 (90.28/38.91)	PSVSMPGRSQSHSG....MMQMNSPMQGMWKDSVGPRMGQREGELDASM..rGGTWDNSW
 1282- 1323 (58.00/23.11)	...SRPGGLGS.DPNRSGEYSLHDE..........LKYMFE....PLFIlaePGSLERGL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20462 with Med13 domain of Kingdom Viridiplantae
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