<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20461

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWTNVFKIGGLHQVSWFQYLPSESDPNLSDRSGKLNQRDVGAQLVLSAHLQLQKDGFLSTWGNSFVGPWDPSQGLHNPDEKIKLWLFIPGRHSSVPDKAKAALSKLRGLASGVWLAPGDSEEVAAALSQALRNSIERALIGLSYMRFGDVFSRYHSSSQGEVFRRGQPVLEFTFTATEEAVFVHVIISAKHVRALSNNDMETIVKRTSSQSSDRLPVIVSPHGMRGRLTGFCPGDLVKQLYFSSGKSKASNGIVGLPHMFSQSSGCQLRGQNCYLEVTLGCENAESEKPLASNSNKNISKQQTSESPGVTKENEKTFIYPAEAVLVPVVQTASARSSLKRFWLQNWMGPSLSGSSFSVQCDAFGTMEGSWHDNGIRSQHGYNSSGNSNSSSSTSSSSDRMTGDDLEADADSISCIKSGLTNADQMNIDGSKMGNKRTRAGMNESYGQASGADAYNSMEINNEQGGSQWDWDDDDRGVVMDIQALLSEFGDFGDFFENDALPFGEPPGTEESQTPTPMFSATDGGDVSSSPFTAMMDTTDPMILTGGFSSFESFNPPLPVIEESTSKNQEIVIKDNVSSGSMTYNPPPNNTEFEYLIKAEAMMTFAPEYGAVETPTTDLISSVIKTPYVPKSRTVESANSSTNSYVYSAVPPRRDATDDKSGPGTNSKDKYLLQSKKYYTHVENGTDKKDEKPSSRDIVVTSREDVTPSTLSGNTGLRSSTRNKLTGAESIVVSSKTGIANELECLMFQAFMCRIRHTLLTPASSLPAGLNRLSGNNNVLYQMHGESNVLQDNNITSKYDIKKKDIPIRIAGDLDSGLLDGSLNSPVGVWRTVGVTKGSKPMSNMEPFGSLPHNSFNEEGMLSYGQRQPLLELLDGMPLLFQQAASFVDVTLDADCGDGPYGWLAMQEQWRRGFSCGPSFAHAGCGGVLASCHSLDIAGVELADPLSAEVHASYAITLLQSDIKSALKSAFATFDGPLTVTDWCKGRNGGDGFPAESSASINDSSVEPMSPPQSAGGSTLSKGMDDMTDSEHQLIRPALLVVPIPAILVGYQDDWLKTSATSLQHWEKAPFEPYAMQKHMNYCVVCPDIDPLTTAAADFFQQLETVYETCKLGTHSAQNMGNQTSKDSGKWSSSGFVLLDCPQSMKIESNSASLVGSISDYFLSLSNGWDLTSFLKSLSKVLKALKLNSIFAPNSKEGNSTPCTVIYVVCPFPEPVAVLKTVVESCVAVGSAVFPSSDKERRSAMQNQVGKALSCSTAVDEASISNVVTISGFSIPKLVLQIVTVDAIFRVTSPSLNEPIILKEIAFTVYNKARRISRSSSDIIPSVSMPGRSQSHSGMMQMNSPMQGMWKDSVGPRMGQREGELDASMRGGTWDNSWQMSRPGGLGSDPNRSGEYSLHDELKYMFEPLFILAEPGSLERGLSPDSMKLLSDDGTSSDAGMGSQMDGSDDGFGSTHQKAPPSLHCCYGWTEDWRWLVCIWTDARGELLDSCTFPFGGISSRQDTKGLQFLFVQILQQGCQILQACSPDTSTARPRDFVITRIGSFFELECQEWQKALYSIGGSEVKKWSLQLRRSVPDGIPASSNGGPLQQQEMSIMQDRNHGKGSAYMKGGLGQPSGRKQQHLGGGGGGGHVAMDNSKGLLQWVQSITFVAVSVDHSLQLVYQADSSPGQIYSLYTLFV
Length1679
PositionKinase
OrganismArtemisia annua (Sweet wormwood)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> campanulids> Asterales> Asteraceae> Asteroideae> Anthemideae> Artemisiinae> Artemisia.
Aromaticity0.08
Grand average of hydropathy-0.351
Instability index47.50
Isoelectric point5.24
Molecular weight181916.77
Publications
PubMed=29703587

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP20461
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     136.44|      31|      97|    1341|    1378|       1
---------------------------------------------------------------------------
  440-  471 (47.90/18.56)	GM.NESYGQASGadaYNSMEINNEQGGS..QWD..WD
 1347- 1378 (55.62/41.56)	GMwKDSVGPRMG...QREGELDASMRGG..TWDNSWQ
 1609- 1637 (32.93/11.24)	...KGGLGQPSG...RKQQHLGGGGGGGhvAMDNS..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     661.77|     216|     338|     147|     402|       2
---------------------------------------------------------------------------
  147-  402 (318.94/255.16)	FGDvFsryhsssqGEVFR.....RGQPvleftfTATEEAVFVHVIISAKHVRALSNNDMETIVKRTssqssDrlPVIVSphGMRGRLTGFCPGDLVKQLYFSSG.....KSKASNGIVGLPHMFSQSSGCQLRGQNCYLevTLGCENAESEKP...LASNSNKN..ISKQQTSESpgvTKENEKTFIYPAeavlVPVVQTAS......ARSSLKRFWLQN..WMGPSLSGSSfsvQCDAfgtmEGSWHDNGIRSQHGYNSSGNSNSSSSTSSSSDRMTG
  488-  726 (342.82/190.90)	FGD.F........GDFFEndalpFGEP......PGTEESQTPTPMFSATDGGDVSSSPFTAMMDTT.....D..PMILT..GGFSSFESFNPPLPVIEESTSKNqeiviKDNVSSGSMTYNPPPNNTEFEYLIKAEAMM..TFAPEYGAVETPttdLISSVIKTpyVPKSRTVES...ANSSTNSYVYSA....VPPRRDATddksgpGTNSKDKYLLQSkkYYTHVENGTD...KKDE....KPSSRDIVVTSREDVTPSTLSGNTGLRSSTRNKLTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     803.88|     206|     332|     804|    1012|       3
---------------------------------------------------------------------------
  804-  996 (311.77/178.44)	..........................................................DiPIRIAGDLDSGLLD..GSLN....SPVGVWRTVG.VTKGSKP..M...........SNMepFGSLPHNS.FNEEGMLSYGQR.QP......LLELLDGMPLLFQQAASFVDVTLDA.....DCGDG....PYG....WLAMQEQWRRGFS.CGPSFAHAGCGGVLASCHSLDIAGVELADPLSAEVHASYAITLLQSDIKSALKS.AFATFDGPLTVTDWC..KGRNGGDGFPAES
 1127- 1327 (238.48/127.93)	SGKWSSSGFVLL.DCPQ...........................................SMKIES..NSASLV..GSISdyflSLSNGW...D.LTSFLKS..L...........SKV..LKALKLNSiFAPNS..KEGNS.TPctviyvVCPFPEPVAVLKTVVESCVAV.............GsavfPSSdkerRSAMQNQVGKALS.CSTAVDEASISNVV.TISGFSIPKLVLQ...IVTVDAIFRVTSPSLNEPIILKEiAFTVYNKARRIS.......RSSSDIIPSVS
 1330- 1583 (253.63/136.59)	GRSQSHSGMMQMnSPMQgmwkdsvgprmgqregeldasmrggtwdnswqmsrpgglgsD.PNR.SGEY..SLHDelKYMF....EPLFILAEPGsLERGLSPdsMkllsddgtssdAGM...GSQMDGS...DDGFGSTHQKaPP......SLHCCYGWTEDWRW...LVCIWTDArgellDSCTF....PFG....GIS.SRQDTKGLQfLFVQILQQGC.QILQAC.SPDTSTARPRDFVITRI.GSF.FELECQEWQKALYS.I.....GGSEVKKWSlqLRRSVPDGIPASS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20461 with Med13 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DQMNIDGSKMGNKRTRAGMNESYGQASGADAYNSMEINNEQGGSQWDWDDD
2) FENDALPFGEPPGTEESQTPTPMFSATDGGDVSSSPFTAMM
3) HDNGIRSQHGYNSSGNSNSSSSTSSSSDRMTGDDLEA
4) LSPDSMKLLSDDGTSSDAGMGSQMDGSDDGFGS
5) NPPLPVIEESTSKNQEIVIKDNVSSGSMTYNPPPNNTEF
6) NSSTNSYVYSAVPPRRDATDDKSGPGTNSKDK
7) PAESSASINDSSVEPMSPPQSAGGSTLSKGMDDM
8) SDIIPSVSMPGRSQSHSGMMQMNSPMQGMWKDSVGPRMGQREGELDASMRGGTW
9) VENGTDKKDEKPSSRDIVVTSREDVTPSTLSGNTGLRSSTRNKLTGA
423
495
371
1421
554
638
993
1320
681
473
535
407
1453
592
669
1026
1373
727










Molecular Recognition Features






MoRF SequenceStartStop




1) YTLFV
1675
1679