<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20459

Description "DNA helicase, ATP-dependent, RecQ type"
SequenceMTKSKCVGDSSGVDTSMRNNLRQHAKSYDNSPSQDKILKSNFLFSLTPQKDLVGETMAATARSFAFNVQNVTKAHGPQVDKAWQALSSLNLSSRSYSRPGKGLPVAMDGNIDSFQDATRATQQCSSDVNKSSTGPTWAEQNSNDIKISKHGRMTEPFATVTTSVSDAGRAESMESGNSGFNTASFSGRDISGIHKNYAKNGSVQVIDVDDEDIRQNLDVDPIIKDRFQSSFTPRSSIPKFPPFTPAASNGVVACEDISLPPELCVECSHGFKLGICPEAASHLQIMKDELISISNELLDDATELNSDQVEKLRKDRLQLNKQVKQLEKYLRSVLIDDEGCKSNFSSYAVPSSRPFQYGTPLTYASKIDPIRLDDQFSMQNYTDGNHKWDPPSFSCSSVGNFGEFSAPVERDYVRKYVEVNYMEGSDDKKWSKRDFSWSKKLEANNKKVFGNHSFRPNQREIINATMSGKDVFVLMPTGGGKSLTYQLPALICKGVTLVISPLVSLIQDQIMHLLQANIPAAYLSANMEWTEQQDILRELCSGHCSYKLLYVTPEKVAKSDVLLRQLENLYARELLDRIVIDEAHCVSQWGHDFRPDYQSLGILKQKFPNTPVLALTATATACVKEDVVQALGLVDCIIFRQSFNRPNLRYSVTPKTKKCVEDIDKFIKDNHFDECGIIYCLSRKDCETVAEKLKECGHKAAFYHGNMDPDKRATVQKMWSKDEVNIICATVAFGMGINKPDVRFVIHHSLPKSIEGYHQECGRAGRDGQRSSCVLYYSYSDYIRIKHMLSQGSMEQSSTVNSGRVQETNTENLLRMVSYCENEVDCRRFLQLIHFGEKFDHVSCRKTCDNCFKTQSLVDKDVTEIAKHLVELVKSAQQQFSASHILEVYKGSMNQMVKKYEHNTLSLHGAGKGVPKGEASRVLHHLVVEDILVEDVKKSDFYGSVSSVLKVNEEKAHNLLAGRQTIILRFPCGTKESKFSRNDITPAKGLLTSSKKSPPRIDTPSQPQLEVDMNLYTKLYSALRMLRRQLLKEAGEGVMAYHIFGNATLEHISKRIPRTKEELLEINGIGKAKVSKYGDKVLETIETILNEYSSEESKYTRDDIMLEKCLLTSTKKTHPQVDTPSQPQPEVDMILYDKLYSNLRMLRTLLVKEAGEGVLAYQVFRNATLELISKRIPRTKEELLEINGIGKAKVSKYGDKVLETIETILNEYSSEESKYTRDDIMLEKCLLTSTKKTHPQVDTPSQPQPEVDMILYDKLYSNLRMLRTLLVKEAGEGVLAYQVFRNATLELISKRIPRTKEELLEINGIGKAKLSMYGDKVLETIETTVNEYYNNNTNKQTISSDSECDDADFAMRSKDAVKSSSNGNPMDVYDFVLSPDSAKWVSKKPDTATAPDVVHYLDADDIGLEDLHLRDE
Length1416
PositionUnknown
OrganismArtemisia annua (Sweet wormwood)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> campanulids> Asterales> Asteraceae> Asteroideae> Anthemideae> Artemisiinae> Artemisia.
Aromaticity0.07
Grand average of hydropathy-0.494
Instability index40.74
Isoelectric point6.48
Molecular weight159165.80
Publications
PubMed=29703587

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
3'-5' DNA helicase activity	GO:0043138	IEA:InterPro
ATP binding	GO:0005524	IEA:UniProtKB-KW
nucleic acid binding	GO:0003676	IEA:InterPro

GO - Biological Process
DNA recombination	GO:0006310	IEA:InterPro
DNA repair	GO:0006281	IEA:InterPro
DNA replication	GO:0006260	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20459
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     720.14|     119|     119|    1073|    1191|       1
---------------------------------------------------------------------------
  980- 1099 (234.19/136.99)	SRNDITPAKGLLTSSKKSPPRIDTPSQPQLEVDMNLYTKLYSALRMLRRQLLKEAGEGVMAYHIFGNATLEHISKRIPRTKEELLEINGIGKaKVSKYGDKVLETIETILNEY.SSEESKY
 1100- 1219 (247.50/145.17)	TRDDIMLEKCLLTSTKKTHPQVDTPSQPQPEVDMILYDKLYSNLRMLRTLLVKEAGEGVLAYQVFRNATLELISKRIPRTKEELLEINGIGKaKVSKYGDKVLETIETILNEY.SSEESKY
 1220- 1340 (238.44/139.61)	TRDDIMLEKCLLTSTKKTHPQVDTPSQPQPEVDMILYDKLYSNLRMLRTLLVKEAGEGVLAYQVFRNATLELISKRIPRTKEELLEINGIGKaKLSMYGDKVLETIETTVNEYyNNNTNKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     184.48|      67|     138|     679|     759|       3
---------------------------------------------------------------------------
  636-  722 (105.14/86.75)	C..IIFRQSFNRPNLRYSVTPKTKKCVE..............................................didkfikdnhfdecgiiYCLSRKDCETVAeKLKECGHKaaFYH..GNMDPDKRATVQKMWSKD
  728-  755 (22.07/18.38)	CatVAFGMGINKPDVRFVIHHSLPKSIE.............................................................................................................
  819-  861 (57.28/28.54)	............................gyhqecgragrdgqrsscvlyysysdyirikhmlsqgsmeqsstvnsgrvqetntenllrmvsYCENEVDCRRFL.QLIHFGEK..FDHvsCRKTCDNCFKTQSLVDKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.85|      35|     138|     442|     477|       6
---------------------------------------------------------------------------
  442-  477 (57.62/41.14)	EANNKKVFGnHSFRPNQRE..IINATMSGKDVFVLMPT
  582-  618 (60.23/38.32)	EAHCVSQWG.HDFRPDYQSlgILKQKFPNTPVLALTAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     229.52|      69|     248|     116|     191|       7
---------------------------------------------------------------------------
  116-  191 (103.35/96.50)	DATRATQQCSSDvNKSSTGPTWAEQNSNDIKISKHGRMTEPFAtvTTSVSDAGRAESMEsgnsGFNTASFSGRDIS
  368-  436 (126.18/93.18)	DPIRLDDQFSMQ.NYTDGNHKWDPPSFSCSSVGNFGEFSAPVE..RDYVRKYVEVNYME....GSDDKKWSKRDFS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20459 with Med34 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) SRPGKGLPVAMDGNIDSFQDATRATQQCSSDVNKSSTGPTWAEQNSNDIKISKHGRMTEPFATVTTSVSDAGRAESMESGNSGFN
97
181










Molecular Recognition Features






MoRF SequenceStartStop




1) DIGLEDLHLRDE
2) MDVYDFVLSPDSAKWVSKK
1405
1370
1416
1388