<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20456

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMGELGQESVEFSTLVTRAAEESYVSLKELVEKSKTSEMSDSEKKISLLKYLVKTQQRMLRLNVLAQWCQQVPLIQYSQQLASTLSSHETCFTQAADSMFFMHEGLQQARAPIYDVPSAIEILLTGTYERLPKCTEDVGIQSTLTEKQQKPVLKKLDTLVRSKLLETALPKEFSEVKISDGTVTLIVQGEFKVLLTLGYRGHLTMWRILHLEVLVGETSGPVKLEETRRFVLGDDLERRMAASDTPFTTLYTILHEFCVALIMDTVIRQVQALRIGRWKDAIRFELISDGNQGQSSAAGSMQTSQDGETDTVGLRTPGVKILYWLDSEKNSGTSDAVSCPFIKIEPGPDLRIKCLHSSFVIDPSTNREAELSIDQSCIDVEKLLLGAIGCNKYTRLLEIYRELGDNSHIRQAGGDVLLHTRVEEPGSEHNKDSTSDSEGQEVLRVRAYGSSFFTLGISIRTGRFLLHSSRSTISSSALKECEEALNGGSVTAAEAFISLRSKSFLHLFACIGRFLGLQVYEHGFSPVKVPKHVLNGFSMLLLGFPDCGSSFFLLMQLDEDFKPLFKLLETQPDVSGKPESSGAMNVVTRIKNVDIDQMHLLEGELNLSLLDNGALTSSTNDTDTIQTSEHVLSNLSLEGSTLLSGFSSIVDEIFEQERRSSAPAFPGQSFNTTYNTTPSHGSAVSQLSHIDSPVSSSWNGSLYPMSNYKGRTQSVSTSSGPGRSSAMKKLSGSKSDQDLASRSPHSAEVGSYITSGPRGSAANARTNAFRNPVTGTPASAPESTATHMPGDNGSRKRTLSDMLDLLPSLKSPEILEQSLKKRKITQQSSSLTHVQSGVVSNIEKYRYVNLIAEANKGNAPSSIYVSALLHVVRHCSLCIKQARLTSQMDALDIPYAEEAGLKQASTNIWFRLPFAVGDTWKHICLRLGRPGSMYWDVKINDPHFMDLWELQKGSISTPWGSGVRIANTSDSDSHIRYDADGVVLTYNSVEADSIKKLVADIQRLSNARTFALGMRKLLVVRPDEKTETSRSNGDVKAAPGAKSGSEAVDKYSEQMRKVFKIEAVGLMSLWFSFGSGVLARFVVEWESGKTGCTMHVSPDQLWPHTKFLEDFINGTEVSSLLDCIRLTAGPLHALAAATRPARAAPVSGVPGAASSVPTVSKPNVYGQMPNSSNPNVGQGSAPNGNPGASAMLAAATVAGRGGPGIVPSSLLPIDVSFVLRGPYWIRIIYRKYFAVDMRCFAGDQVWLQPATPPKGGPTVGGSLPCPQFRPFIMEHVAQELNGLDPNFTGSQPSGVPTTSGAFSGPQPSANGNRAGLVGPTGMSRSQPAGFNRPTNPLAVSSNSPLGSGLPLRRAPGTVVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHSQQQQQQNAVVAQEELSQSEISEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLAQAQGGDIPPAQRSRIELCLENHTGVYTDGNNNSENTSTSKSNIHYDRPHNAVDFGLTVVLDPAHIPHINAAGGAAWLPYCVSVRLKYSFGENPSVSFLGMEGSHGGRSCWLRLEDWEICKQRVIRTVDMNGSSGGDVNQGRLRIVADNVQRALHMCLQGLRTGGSSNGGTGAIVA
Length1713
PositionTail
OrganismArtemisia annua (Sweet wormwood)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> campanulids> Asterales> Asteraceae> Asteroideae> Anthemideae> Artemisiinae> Artemisia.
Aromaticity0.07
Grand average of hydropathy-0.198
Instability index45.23
Isoelectric point7.00
Molecular weight186109.09
Publications
PubMed=29703587

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP20456
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.53|      43|     449|    1076|    1118|       2
---------------------------------------------------------------------------
 1076- 1118 (79.61/54.73)	VLARF..VVEWESG.KTGCTMHVSPDQ.......LWPHTKFLEDFINGTEVSS
 1523- 1575 (60.92/39.86)	VLREFlkLIAWKKGlAQAQGGDIPPAQrsrielcLENHTGVYTDGNNNSENTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     307.89|      77|     449|     677|     756|       3
---------------------------------------------------------------------------
  677-  756 (121.46/80.65)	PSHGSAVSQLSHIDSPVSSSwngSLYPMSN.YKGRTQSVSTSSGPGRSSAMKKLSGSKSDQDLASRSPHSAEVGSYITSGP
  771-  839 (98.85/56.96)	PVTGTPAS......APESTA...THMPGDNgSRKRTLSDMLDLLPSLKSP.EILEQSLKKRKITQQSSSLTHVQSGVVS..
 1129- 1181 (87.58/49.49)	PLHALAAATRPARAAPVSG........................VPGAASSVPTV....SKPNVYGQMPNSSNPNVGQGSAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     314.22|      89|     448|      22|     113|       4
---------------------------------------------------------------------------
   22-  113 (139.41/95.39)	SYVSLKELVEKSKTSEMSDSEKKISL....LKYLVKTQQRMLRLNVLAQWCQqvPlIQYSQQLASTL....SSHETCFTQAADSMFFMHEGLQQARAPIY
  473-  564 (144.00/89.05)	SSSALKECEEALNGGSVTAAEAFISLrsksFLHLFACIGRFLGLQVYEHGFS..P.VKVPKHVLNGF....SMLLLGFPDCGSSFFLLM.QLDEDFKPLF
  624-  664 (30.81/12.27)	........................................................IQTSEHVLSNLslegSTLLSGFSSIVDEIF...EQERRSSAPAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.51|      22|      34|    1289|    1310|       5
---------------------------------------------------------------------------
 1252- 1288 (24.11/ 9.16)	..PKGG..PTVGGSLPCPQfrpfimehvaqelngldPNFTG
 1289- 1310 (43.82/23.80)	SQPSGV..PTTSGAFSGPQ.................PSANG
 1324- 1347 (34.58/16.93)	SQPAGFnrPTNPLAVSSNS.................PLGSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     253.66|      83|    1197|     150|     237|       6
---------------------------------------------------------------------------
  150-  237 (122.50/103.71)	PVLKKLDTLVRSKL...LETALPKEFSEVKISDGTVTLIVQGefKVLL.TLGYRGhlTMWRILHLEVLVGETSGPVkLEETRRFVLGDDLER
 1349- 1435 (131.16/92.24)	PLRRAPGTVVPAHVrgeLNTAIIGLGDDGGYGGGWVPLVALK..KVLRgILKYLG..VLWLFAQLPELLKEILGSI.LKDNEGALLNLDQEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     195.07|      60|     710|     883|     951|      11
---------------------------------------------------------------------------
  883-  951 (91.42/75.44)	LTSQMDALDIPYAEEA.GLKQASTNIWFRLPFAVGDTwKHICLrLGRPGSM....YWdVKINDphfmdlWELQK
 1594- 1658 (103.65/57.72)	LTVVLDPAHIPHINAAgGAAWLPYCVSVRLKYSFGEN.PSVSF.LGMEGSHggrsCW.LRLED......WEICK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20456 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GLDPNFTGSQPSGVPTTSGAFSGPQPSANGNRAGLVGPTGMSRSQPAGFNRPTNPLAV
2) MSNYKGRTQSVSTSSGPGRSSAMKKLSGSKSDQDLASRSPHSAEVGSYITSGPRGSAANARTNAFRNPVTGTPASAPESTATHMPGDNGSRKRTLSDML
3) SSAPAFPGQSFNTTYNTTPSHGSAVSQLSHI
1281
704
659
1338
802
689










Molecular Recognition Features






MoRF SequenceStartStop




NANANA