<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20455

Description Methionine gamma-lyase
SequenceMADTIHNNNVVISSSKKRMTPDDPNHEDDFIAKKLPPTKPSWEDPVSALANARHEFGEHGGVNMSIEASATFTVMEPETLSRMFAGELGPDRDFFIYSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAISSVLLTLVSSGDNIVASQTLYGGTHALLTHFLPRSSNIQTTFVDIRDLEKVKEAIVEGRTKVLYFESMSNPTLTVANIPELSRIAHEKGVTVVVDNTFAPMVVSPARLGADVVVHSISKYISGGADIIAGAVCGPASLVNSLMDLHQGALMLLGPTMNAKVAFELSERIPHLGLRVKEHCHRALVYAQRMKKMGLKVIYPGLEDHPDHLLLKSIANKEYGFGGMLCLDMGTEARANKLMNLLQNYTQFGLMAVSLGYYETLMSCSGSSTSSELNEEEQALAGISPGLVRMSVGYSGTLEQRWGQFEKALSKLQDMGLNALVMEMDNMAKLSEKCNIQVPMEVLNCIAKNQITKGKTDAFKGLRRHLLEELEQAFPDEVEDYREIRASSAAVSSLNPPEVSISALISLFCYVGIPYFYGNQLNALVMEMDNMAKLSEKCNIQVPMEVLNLIDDGKNPDEFTRDVLNSCIAKNQITKGKTDAFKGLRRHLLEELEQAFPDEVEDYREIRASSAAVSSLNPPEVSISALISLFGMPYLYRSRLLVIGVMPHLVLEAGLRRHLLEELEQAFPDEVEDYREIRASSAAVSSLNPPEVSISALISLFGMPYLYRSRLLVIGVMPHLVLEAESMRLAQAQSILPNGDMKVKPEM
Length778
PositionMiddle
OrganismArtemisia annua (Sweet wormwood)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> campanulids> Asterales> Asteraceae> Asteroideae> Anthemideae> Artemisiinae> Artemisia.
Aromaticity0.06
Grand average of hydropathy-0.058
Instability index41.95
Isoelectric point5.38
Molecular weight85600.54
Publications
PubMed=29703587

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
lyase activity	GO:0016829	IEA:UniProtKB-KW
pyridoxal phosphate binding	GO:0030170	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
transsulfuration	GO:0019346	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20455
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     429.93|      68|      68|     614|     681|       1
---------------------------------------------------------------------------
  492-  556 (128.16/80.18)	GLRRHLLEELEQAFPDEVEDYREIRASSAAVSSLNPPEVSISALISLFcyvGIPYFYGNQL......NALV
  614-  681 (150.89/95.67)	GLRRHLLEELEQAFPDEVEDYREIRASSAAVSSLNPPEVSISALISLF...GMPYLYRSRLLVIGVMPHLV
  685-  752 (150.89/95.67)	GLRRHLLEELEQAFPDEVEDYREIRASSAAVSSLNPPEVSISALISLF...GMPYLYRSRLLVIGVMPHLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.21|      28|     103|     453|     480|       2
---------------------------------------------------------------------------
  453-  480 (61.70/42.88)	MEMDNMAKLSEKCNIQVPMEVLN..................CIAKN
  557-  602 (50.50/33.81)	MEMDNMAKLSEKCNIQVPMEVLNliddgknpdeftrdvlnsCIAKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.88|      11|     121|     481|     491|       3
---------------------------------------------------------------------------
  481-  491 (22.94/17.47)	QITKGKTDAFK
  603-  613 (22.94/17.47)	QITKGKTDAFK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.79|      13|      34|     380|     392|       4
---------------------------------------------------------------------------
  380-  392 (24.39/13.64)	GLMAVSLGYYETL
  417-  429 (24.41/13.66)	GLVRMSVGYSGTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     152.83|      44|      63|      18|      61|       5
---------------------------------------------------------------------------
   18-   61 (80.53/46.87)	RMTPDDPNHEDDFI..AKKLPPTKPSWEDPVSALANARHEFGEHGG
   82-  127 (72.30/41.41)	RMFAGELGPDRDFFiySRHFNPTVLNLGRQMAALEGTEAAYCTASG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.01|      18|      34|     288|     305|       6
---------------------------------------------------------------------------
  288-  305 (31.50/20.08)	MNAKVAF.ELSERIPHLGL
  324-  342 (28.51/17.50)	MGLKVIYpGLEDHPDHLLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.56|      10|      32|     230|     239|       7
---------------------------------------------------------------------------
  230-  239 (18.59/10.78)	APMVVSPARL
  260-  269 (18.98/11.16)	AGAVCGPASL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.18|      27|      32|     154|     182|       8
---------------------------------------------------------------------------
  154-  182 (39.96/33.50)	GTHALLthFLPRSSNIQTTFVDIRDLEKV
  189-  215 (45.22/30.41)	GRTKVL..YFESMSNPTLTVANIPELSRI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20455 with Med10 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




1) DFIAKKL
29
35