<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20455

Description Methionine gamma-lyase
SequenceMADTIHNNNVVISSSKKRMTPDDPNHEDDFIAKKLPPTKPSWEDPVSALANARHEFGEHGGVNMSIEASATFTVMEPETLSRMFAGELGPDRDFFIYSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAISSVLLTLVSSGDNIVASQTLYGGTHALLTHFLPRSSNIQTTFVDIRDLEKVKEAIVEGRTKVLYFESMSNPTLTVANIPELSRIAHEKGVTVVVDNTFAPMVVSPARLGADVVVHSISKYISGGADIIAGAVCGPASLVNSLMDLHQGALMLLGPTMNAKVAFELSERIPHLGLRVKEHCHRALVYAQRMKKMGLKVIYPGLEDHPDHLLLKSIANKEYGFGGMLCLDMGTEARANKLMNLLQNYTQFGLMAVSLGYYETLMSCSGSSTSSELNEEEQALAGISPGLVRMSVGYSGTLEQRWGQFEKALSKLQDMGLNALVMEMDNMAKLSEKCNIQVPMEVLNCIAKNQITKGKTDAFKGLRRHLLEELEQAFPDEVEDYREIRASSAAVSSLNPPEVSISALISLFCYVGIPYFYGNQLNALVMEMDNMAKLSEKCNIQVPMEVLNLIDDGKNPDEFTRDVLNSCIAKNQITKGKTDAFKGLRRHLLEELEQAFPDEVEDYREIRASSAAVSSLNPPEVSISALISLFGMPYLYRSRLLVIGVMPHLVLEAGLRRHLLEELEQAFPDEVEDYREIRASSAAVSSLNPPEVSISALISLFGMPYLYRSRLLVIGVMPHLVLEAESMRLAQAQSILPNGDMKVKPEM
Length778
PositionMiddle
OrganismArtemisia annua (Sweet wormwood)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> campanulids> Asterales> Asteraceae> Asteroideae> Anthemideae> Artemisiinae> Artemisia.
Aromaticity0.06
Grand average of hydropathy-0.058
Instability index41.95
Isoelectric point5.38
Molecular weight85600.54
Publications
PubMed=29703587

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
lyase activity	GO:0016829	IEA:UniProtKB-KW
pyridoxal phosphate binding	GO:0030170	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
transsulfuration	GO:0019346	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20455
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     429.93|      68|      68|     614|     681|       1
---------------------------------------------------------------------------
  492-  556 (128.16/80.18)	GLRRHLLEELEQAFPDEVEDYREIRASSAAVSSLNPPEVSISALISLFcyvGIPYFYGNQL......NALV
  614-  681 (150.89/95.67)	GLRRHLLEELEQAFPDEVEDYREIRASSAAVSSLNPPEVSISALISLF...GMPYLYRSRLLVIGVMPHLV
  685-  752 (150.89/95.67)	GLRRHLLEELEQAFPDEVEDYREIRASSAAVSSLNPPEVSISALISLF...GMPYLYRSRLLVIGVMPHLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.21|      28|     103|     453|     480|       2
---------------------------------------------------------------------------
  453-  480 (61.70/42.88)	MEMDNMAKLSEKCNIQVPMEVLN..................CIAKN
  557-  602 (50.50/33.81)	MEMDNMAKLSEKCNIQVPMEVLNliddgknpdeftrdvlnsCIAKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.88|      11|     121|     481|     491|       3
---------------------------------------------------------------------------
  481-  491 (22.94/17.47)	QITKGKTDAFK
  603-  613 (22.94/17.47)	QITKGKTDAFK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.79|      13|      34|     380|     392|       4
---------------------------------------------------------------------------
  380-  392 (24.39/13.64)	GLMAVSLGYYETL
  417-  429 (24.41/13.66)	GLVRMSVGYSGTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     152.83|      44|      63|      18|      61|       5
---------------------------------------------------------------------------
   18-   61 (80.53/46.87)	RMTPDDPNHEDDFI..AKKLPPTKPSWEDPVSALANARHEFGEHGG
   82-  127 (72.30/41.41)	RMFAGELGPDRDFFiySRHFNPTVLNLGRQMAALEGTEAAYCTASG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.01|      18|      34|     288|     305|       6
---------------------------------------------------------------------------
  288-  305 (31.50/20.08)	MNAKVAF.ELSERIPHLGL
  324-  342 (28.51/17.50)	MGLKVIYpGLEDHPDHLLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.56|      10|      32|     230|     239|       7
---------------------------------------------------------------------------
  230-  239 (18.59/10.78)	APMVVSPARL
  260-  269 (18.98/11.16)	AGAVCGPASL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.18|      27|      32|     154|     182|       8
---------------------------------------------------------------------------
  154-  182 (39.96/33.50)	GTHALLthFLPRSSNIQTTFVDIRDLEKV
  189-  215 (45.22/30.41)	GRTKVL..YFESMSNPTLTVANIPELSRI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20455 with Med10 domain of Kingdom Viridiplantae
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