<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20437
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MDGNLAISLDKLPVKRLEAIEENGAERFPPDLSYDDNRVNLIRRVDFAWAVEREDPKKKQKKGDDTAAASGSKDAASAPPWPWQNMVENLQLAHQELSVIIDLINTVEANDQVTVAGMTRPKPLPNELLSDLAVSTATKLQSFRHLGKYFKQSAKALEKQVAREARFYGALIRLQQNWKVKRHRMAASAAGNEGFYIDLFDNTLYDPTSVIRPTPLSSVRVEHDSAGMLALNLSSKACNPLQFGFVSGNSDNISEGSDRIDSELSGETNEEAEGDDASVKKRHSDLREVQRAVFDEQVFNLINQEAFVPSIGVNVTGIRENHLQLNIDQEASVFISLGSSAQDNEESDDKTAVIPFIDGEDKVQKRSFLPNTISSEILLKQLFHEHVFVRAKNRSSSPNKSQLSIQPPKDGSNLLGHFCLSLAHRIFSSKVLVELEELASSVSYVRLMSHPTWHSRTSAWTLVVDVPQSILHTGTVEKSVRSQFRTKVVVNDDCINIEGEGAPNVVGLFKGKSENSSSMNRYECNLADLHVILLRQVASQIIRWLHEEALIVGIKASRDFLSLSFEVEQGELVGLVAHVDPEDSEGGISWWLVMGKGIGDEYKLQREDSDGETKRFLGHLSLDVLYATLLDLVTLCNNGGSL |
Length | 642 |
Position | Head |
Organism | Artemisia annua (Sweet wormwood) |
Kingdom | Viridiplantae |
Lineage | Eukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta>
Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae>
asterids> campanulids> Asterales> Asteraceae> Asteroideae> Anthemideae>
Artemisiinae> Artemisia.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.339 |
Instability index | 43.41 |
Isoelectric point | 5.31 |
Molecular weight | 71223.28 |
Publications | PubMed=29703587
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP20437
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 82.38| 23| 23| 564| 586| 1
---------------------------------------------------------------------------
564- 586 (39.03/21.82) SFEVEQGELVGLVAHVDPEDSEG
589- 611 (43.35/24.93) SWWLVMGKGIGDEYKLQREDSDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 42.64| 12| 15| 247| 258| 2
---------------------------------------------------------------------------
247- 258 (21.40/14.73) SGNSDNISEGSD
265- 276 (21.24/14.57) SGETNEEAEGDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 233.50| 74| 326| 70| 147| 4
---------------------------------------------------------------------------
70- 147 (118.91/90.51) SGSKDAAS.APPWPWQNMVEN..LQLAHQELSVIIdLINTVEANDQVT.VAGMTRPKPLPNELLSDLAVSTAtklQSFRHLG
397- 474 (114.59/75.51) SPNKSQLSiQPPKDGSNLLGHfcLSLAHRIFSSKV.LVELEELASSVSyVRLMSHPTWHSRTSAWTLVVDVP...QSILHTG
---------------------------------------------------------------------------
|