<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20436

Description "DNA helicase, ATP-dependent, RecQ type"
SequenceMSNNNPGGGFQHVEKRMKDNWSQHAQKHDNFSNPDQFLRSNFLFSLPTQKPRAEGAMTVAARSLSCQIQKVENSHSPHADKAWQALSNLKLSSKNYIKPGKSRPLANNGGTTFSKDVGRPTHQYSSVNNTNFGRTQENSSNEFNVQHSLPRHMTNQFAAVAPSVAEAGRLGTVLNGGYASSSMDFGGRTMNSSYSNTTNSGHGIHNYTTSASHFKGFQETDTGGLDDDDDIFQDLDVDQIVSQHYQSTCTPKSSISKFPPVTPAVSNNMARHDDIGLPPELCEGCNHGYKLGHCPEASNHLQLMKDMLISISNDLLDNVDLDPDQTEKLRQDRLTLNKQIQQLEKHLHASSVSDKGPQSNFASHATTGSFQYETPTFASRVDPTRLDDQFYMDTTTDVPNRWDSPSVSYDSVSYSTNCSAPREPYVPKFVDVNYTEGSNDKKWSKRDFPWTQELEANNKRVFGNHSFRPNQREVINATMSGKDVFVLMPTGGGKSLTYQLPALICSGITLVISPLVSLIQDQIMHLLQANISATYLSANMEWTDQQDILREICSGNCSYKLLYVTPEKVAKSDFLLRQLEDLHARELLDRIVIDEAHCVSQWGHDFRPDYQSLGILKKKFPKTPVLALTATATASVKEDVVQALGLADCVIFRQSFNRPNLRFSVVPKTNKCLEDIDKFIKENHRNECGIIYCLSRMDCEKVAEKLQEYGHKVAFYHGSMDPDLRASVQKAWSKDQINIICATVAFGMGINKPDVRFVIHHSLPKSIEGYHQECGRAGRDGHLASCVLYYSYSDYIRVKHMLSFGATEQSTFTSGYPRTGSTNSGRLETNNDNLLRMVSYAENDVDCRRFLQLVHLDEKFDSLNCKKTCDNCQNSQTLVDKDVTQIAKQLVELVKLVRQQFSASHILDVYRGSVSQIVKKNNHDTLRLHGAGKHLGKGEASRVLRHLVVEEILVEHVKKSDYGSVSSVLKVNENKAGILLAGRQTINLRFPSAVKPSKSHKNNATSVRGSLTSSKQSPLLLDSPDSDEPQPGTDVVLSAKIFTTLRTLRTTLLAELGGGFGAHHIFTNATLQSIGKKIPRTKEELLEVDGIGKAKLKKYGDRVLEVIETTIKEHNGNTQPDQIQNKRNKGSVASQRQPSLQNGSLSKSGKSSTSNSTDSVKRRRSGFKDPFKNSKDDDDFIASTARSKKRAVENLNPSVDPVDTFNDITEEELYFYASAYDDASNPKGKENIGGRVLPAW
Length1240
PositionUnknown
OrganismArtemisia annua (Sweet wormwood)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> campanulids> Asterales> Asteraceae> Asteroideae> Anthemideae> Artemisiinae> Artemisia.
Aromaticity0.07
Grand average of hydropathy-0.604
Instability index39.89
Isoelectric point8.24
Molecular weight138030.05
Publications
PubMed=29703587

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
3'-5' DNA helicase activity	GO:0043138	IEA:InterPro
ATP binding	GO:0005524	IEA:UniProtKB-KW
nucleic acid binding	GO:0003676	IEA:InterPro

GO - Biological Process
DNA recombination	GO:0006310	IEA:InterPro
DNA repair	GO:0006281	IEA:InterPro
DNA replication	GO:0006260	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20436
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.08|      23|      24|     530|     552|       1
---------------------------------------------------------------------------
  530-  552 (39.81/27.13)	NISATYLSANMEWTDQQD.ILREI
  556-  579 (34.27/22.34)	NCSYKLLYVTPEKVAKSDfLLRQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.90|      26|      26|     342|     367|       2
---------------------------------------------------------------------------
  342-  367 (44.71/31.07)	QLEKHLHASSVSDKGPQSNFASHATT
  371-  396 (47.19/33.27)	QYETPTFASRVDPTRLDDQFYMDTTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.29|      23|      26|     399|     424|       3
---------------------------------------------------------------------------
  399-  424 (39.13/33.96)	PNRWDspsVSYDSVSYSTNCSAPREP
  427-  449 (43.16/28.03)	PKFVD...VNYTEGSNDKKWSKRDFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.11|      16|      30|     713|     734|       4
---------------------------------------------------------------------------
  650-  665 (27.98/10.11)	VIFRQSFNRPNLRFSV
  744-  759 (28.13/17.96)	VAFGMGINKPDVRFVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.40|      25|      30|     100|     127|       5
---------------------------------------------------------------------------
  100-  127 (39.44/32.92)	GKSRplaNNGGTTFSKDVGRPTH...QYSSV
  133-  160 (38.95/23.71)	GRTQ...ENSSNEFNVQHSLPRHmtnQFAAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.24|      10|      30|     178|     187|       6
---------------------------------------------------------------------------
  178-  187 (19.26/12.79)	YASSSMDFGG
  207-  216 (18.98/12.48)	YTTSASHFKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.04|      14|      25|     938|     953|       7
---------------------------------------------------------------------------
  938-  953 (18.63/24.65)	GEASRVLRhlVVEE...IL
  963-  979 (18.41/13.60)	GSVSSVLK..VNENkagIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.00|      16|      31|     266|     296|      10
---------------------------------------------------------------------------
  266-  283 (25.74/41.04)	SNNMArhDDIGLPPELCE
  312-  327 (28.26/ 6.78)	SNDLL..DNVDLDPDQTE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.23|      10|      25|    1069|    1078|      12
---------------------------------------------------------------------------
 1069- 1078 (15.71/10.80)	ATLQSIGKKI
 1094- 1103 (16.52/11.81)	AKLKKYGDRV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.37|      15|      35|    1187|    1201|      13
---------------------------------------------------------------------------
 1187- 1201 (25.59/16.09)	SKKRAVENLNPSVDP
 1224- 1238 (26.78/17.20)	SNPKGKENIGGRVLP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20436 with Med34 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IETTIKEHNGNTQPDQIQNKRNKGSVASQRQPSLQNGSLSKSGKSSTSNSTDSVKRRRSGFKDPFKNSKDDDDFIASTARSKKRAVENLNPSVDPVDT
2) MSNNNPGGGFQHVEKRMKDNWSQHAQKHDNFSNP
3) SKNYIKPGKSRPLANNGGTTFSKDVGRPTHQYSSVNNTNFGRTQENSSNEFNVQHSLPRH
4) SKSHKNNATSVRGSLTSSKQSPLLLDSPDSDEPQ
5) TQKPRAEGAMTVAARSLSCQIQKVENSHSPHADKAWQA
1107
1
93
997
48
1204
34
152
1030
85










Molecular Recognition Features






MoRF SequenceStartStop




1) KENIGGRVLPAW
2) VDTFNDITEEELYFYASAYDDA
1229
1202
1240
1223